Protein
Peroxisome proliferator-activated receptor alpha
Organism
Phascolarctos cinereus
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Sequence
MVDTESQICPLSPFGDDDLESPLSEEFLQEMGSIQEISPSIGDDSSGTFAFAEYRCLGSGPGSDGSIITDTLSPASSPSSVSYTPIAGSADDSSSATLNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFQKCLSDGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLEDSEVADLKSLAKRIYEAYLKNFNMNKIKARIILAGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSIPGFSNLNLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIERMQESIVHVLQLHLQNNHPDDVFLFPKLLQKMADLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY