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PPARA

Gene
ppara
Protein
Peroxisome proliferator-activated receptor alpha
Organism
Xenopus laevis
Length
474 amino acids
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by lipids. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Mass
52.856 kDa
Sequence
MSTIMVDTNSELCILTPLDEDDLESPLSGEFLQDIVDIQDITQTIGDDGSTPFGASEHQFFGNSPGSIGSVSTDLTDTLSPASSPASITFPAASGSAEDAACKSLNLECRVCSDKASGFHYGVHACEGCKGFFRRTIRLKLVYDRCERMCKIQKKNRNKCQYCRFEKCLNVGMSHNAIRFGRMPRSEKAKLKAEVLMCDQDVKDSQMADLLSLARLIYDAYLKNFNMNKVKARAILTGKASNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSIPGFTELDLNDQVTLLKYGVYEAMFAMLASVMNKDGMLVAYGNGFITREFLKSLRKPIGDMMEPKFEFAMKFNALELDDSDLSLFVAALICCGDRPGLVNIPSIEKMQESIVHVLKLHLQSNHPDDSFLFPKLLQKMADLRQLVTEHAQLVQTIKKTETDAALHPLLQEIYRDMY

Gene
PPARA
Protein
Peroxisome proliferator-activated receptor alpha
Organism
Homo sapiens
Length
468 amino acids
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Mass
52.225 kDa
Sequence
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

Gene
Ppara
Protein
Peroxisome proliferator-activated receptor alpha
Organism
Mus musculus
Length
468 amino acids
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Mass
52.347 kDa
Sequence
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

Gene
PPARA
Protein
Peroxisome proliferator-activated receptor alpha
Organism
Phascolarctos cinereus
Length
468 amino acids
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Mass
52.199 kDa
Sequence
MVDTESQICPLSPFGDDDLESPLSEEFLQEMGSIQEISPSIGDDSSGTFAFAEYRCLGSGPGSDGSIITDTLSPASSPSSVSYTPIAGSADDSSSATLNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFQKCLSDGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLEDSEVADLKSLAKRIYEAYLKNFNMNKIKARIILAGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSIPGFSNLNLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIERMQESIVHVLQLHLQNNHPDDVFLFPKLLQKMADLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

Gene
Ppara
Protein
Peroxisome proliferator-activated receptor alpha
Organism
Rattus norvegicus
Length
468 amino acids
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Mass
52.377 kDa
Sequence
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

Gene
PPARA
Protein
Peroxisome proliferator-activated receptor alpha
Organism
Canis lupus familiaris
Length
468 amino acids
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Mass
52.123 kDa
Sequence
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFSFTEYQYLGSGPGSDGSVITDTLSPAPSPSSVTHPAAPGGAEEPSSVALNIECRICGDRASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEQDPEDAETADLKSLAKRIYEAYLKNFNMNKVKARVILAGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLKLHLQTNHPDNIFLFPKLLQKMADLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY

Gene
PPARA
Protein
Peroxisome proliferator-activated receptor alpha
Organism
Cavia porcellus
Length
467 amino acids
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Mass
52.313 kDa
Sequence
MVDMESPLCPLSPLEAEDLESPLSEYFLQEMGTIQDISRSLGEDSSGSFGFPEYQYLGSGPGSDGSVITDTLSPASSPSSVSYPEVPCGVDEPPSSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEVLTCDRDSEGAETADLKSLAKRIYEAYLKNFHMNKVKARIILAGKTSSHPLFVIHDMETLCTAEKTLMAKVVSDGIRDKEAEVRIFHCCQCVSVETVTNLTEFAKAIPGFASLDLNDQVTLLKYGVYEAIFTMLSSTMNKDGMLVAYGHGFITREFLKNLRKPFCDMMEPKFNFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIDHIEKMQEAIVHVLKLHLQSNHPDDTFLFPKLLQKLADLRQLVTEHAQLVQVIKTESDAALHPLLQEIYRDMY