polr3a

DNA-directed RNA polymerase III subunit rpc1

1450 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

Belongs to the RNA polymerase beta' chain family.

163.727 kDa

MIELLKEDDAPKKIGHIQFGLLSEDDIVRLSHVQIVNRELFDLVKRKPTPYGVLDNKLGTSDKQAMCTTCGLSIVDCVGHFGYIKLQLPVFHIGYLKNIMNILQMICKSCSTILLNEEKKQYYLRKMRNKKMDNLQRKSLLKKIFLECRKTKECLKCGSTNGMIKKSGAFKIIHEKYKGKTESLQDYYALYDDAIKYNPEMKSHIKKAQDDLNPLVALNLFKKISYQDIEIMNMDPVIGRPERLILTYMLVPPVSIRPSVPMDGGSGTNEDDLTMKLSEILHINEHIRSNVDRAEMSAIMEDWDYLQASCAIYINSDVPGLPLQMKPTKAVRGLSQRLKGKTGRFRGNLSGKRVDFSGRTVISPDPNLNIDEVAVPQLIALTMTYPERVTDYNIERLQKYVINGPDRHPGANYIIYADGVKKWLKFGNREKFAAELKIGDIVERHIIDGDIMLFNRQPSLHKLSIMSHKARVMPWRTLRFNECVCTPYNADFDGDEMNIHLPQTEEARAEATILMGVTNNLITPRNGEPLVAATQDFLTASYLISRRDAFYERYRFALMCTHFADANEHIDLPPPAILKPVELWTGKQIFEVLLRPSVKSHVLCNFETRSRTYSKNLYMCPKDGYVYFRNSELMCGSIDKSIIGGGNKNSLFHILMRDFSPTIAANCMTRLAKLCARFLGDQGFSIGIPDIKPAEDLDRKKREIIETAYKKCAVFLKDYESGSLQLSSGCSMEQTFEAKMNQTLSQIRDDCGKLCVNDLPNYNSPLIMGLCGSKGSNINIAQMICCVGQQIVNGTRIPNGFTNRTTPHFKHFAKNPKSKGFVSNSFYTGMIPTEFFFHTMGGREGLVDTAVKTAETGYMQRRLMKALEDLSTHYDYTVRDSIGGIVQFIYGDDGLDPAGMEAKDRPVDFLRAMMSVKSTRQCRNEPEMKPFEIRKLVESIIDSSKFEACTDLFKNEIRVFFNGNEKTKGYIQELISLRKQFKLSSFDLNDNEDEIIIEDNSPMDISTTTTTTTTTTTNNAVKITNITTDIEMNESNKEENDKIEKERIEKEKESKRLKLLGERFANEHVVNQIHRITKTQIELFLDICLDKYSRARIEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINAAKNISTPIITASLNCDYDIRSARIVAGRIEKTTLGHVATHIKEVVKRAGCYLSIKIDKNFVDSLQLEINSKTISQSIASTKGLKLKPEQITTNGDYKLRIVPPANIREGSLYYLQFLKNNLPAVIVKGIPTVNRVVISKVDEKQERYQLLVEGYDLRAVMATPGIKGTHTTSNHIMECENTLGIETARNTIMSEIDMIMTSHGMSIDIRHVMLLADLMSFKGEILGITRFGIAKMKESVLMLASFEKTTDHLFDAAVHHRQDDIVGVSECIIMGVVIPLGTGLFKLLRKSNKNNLPKKSLLLQD

POLR3A

DNA-directed RNA polymerase III subunit RPC1

1390 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

Belongs to the RNA polymerase beta' chain family.

155.704 kDa

MVKEQFRESDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNHHAPLQYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFKAVIGILQMICKTCCRIMLSVEEKKQFLDYLKRPGLTYLQKRGLKKKVSEKCRKKNTCPYCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSTFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDIPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPIHVAKILTFPEKVNKANINFMRKLVRNGPDVHPGANFIQQRHTQMKRFLKYGNREKMAQELKFGDIVERHLIDGDIVLFNRQPSLHKLSIMAHIARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPAILKPVTLWTGKQVFSSILKPSDDCPVKANLRTKGKQYCGKGEDLCYNDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQVEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLHAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLIMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPLEFKRVLDNIRAVYPCRSEPALSKNELVLTSESIMKKNEFLCCRDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQLEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDPDFARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICISKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQSLKEELPKVVVQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTKTSSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADKESTPPRRPLIFDNNEFHIPIVT

POLR3A

DNA-directed RNA polymerase III subunit RPC1

1390 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Belongs to the RNA polymerase beta' chain family.

155.641 kDa

MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLCCQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFDTNEFHIPLVT

POLR3A

DNA-directed RNA polymerase III subunit RPC1

1390 amino acids

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Belongs to the RNA polymerase beta' chain family.

155.791 kDa

MVKEQFRETDVAKKISHICFGMKSAEEMRQQAHIQVVSKNLYSQDNNHSPLLYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNTCHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSSFLQSFETAIEHNKEVEPLLGKAQENLNPLVVLNLFKRIPAEDIPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVRNGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKFGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDDNPVRANLRTKGKQYCGRGEDLCVNDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCRSEPALSKNELLLSAESIMKKNEFLCCQDSFLQEIKKFIKEVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQIEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICMSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKANRDPSPPRRPLIFDTNEFHIPLVT