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PMEL

Gene
PMEL
Protein
Melanocyte protein PMEL
Organism
Gallus gallus
Length
763 amino acids
Function
Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase.
Similarity
Belongs to the PMEL/NMB family.
Mass
77.038 kDa
Sequence
MRLHGAIVLLAALLALVTAQQRGGGRSRGGVKGSAWGGRPAPFRSWDTARYRPWQEGTARQNDCWRGGDVTFDISNDAPTLVGARATFSIALRFPGTQTVLPDGRVVWSQNCTVNGTRMLQGDPVYPEQLAEGSDGVFPDGQPFPRSAWGKRGRFVYVWWTWGRYWQVVDGATSQLTVGTDGVALGSYTMEVVVYHYRGRQRFIPIGHASTQFSITDQVPIAVDVTQLEVAAGDGGSFVRNRPVAFNVRLHDPSHYLRDADISYSWDFGDQSGTLISRSPTVTHTYLQAGSFAARLVLQAAIPLSSCGTSAPPVVDPTTGPVPSLGPTATQPVGPTGSGTATAPSNLTGSGTAAAPGTTAAPRASGAPAEPTGVSVAVLSDSAATEPLPDPVLSTAVADAAAGTDPTADPLPPTSVSSGGDAPGTVAPTAVEGSVAAGVGTAEDVAAATPGATAADVAVDTAGATDGDAVGPTAAATAESIADPTAGATDGDAVGATAESIADPTAGATDGDAVGPTAAATAESIADPTAGATAVSSGSATAGATAEPLLLVKRQAPEAEPTGCVLYRYGTFSTELNIVQGIESVAIVQVVPAAPEGSGNSVELTVTCEGSLPEEVCTVVADAECRTAQMQTCSAVAPAPGCQLVLRQDFNQSGLYCLNVSLANGNGLAVASTHVAVGGASPAASGTTLTVGLLWAPLIAAALGTAAYTYRRVKYSPLLPTAPTAPRPHSWLPPGATLRLLLRQAFGGAPSGESSPLLRANAV
Protein
Melanocyte protein PMEL: PMEL

Gene
PMEL
Protein
Melanocyte protein PMEL
Organism
Homo sapiens
Length
661 amino acids
Function
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Similarity
Belongs to the PMEL/NMB family.
Mass
70.255 kDa
Sequence
MDLVLKRCLLHLAVIGALLAVGATKVPRNQDWLGVSRQLRTKAWNRQLYPEWTEAQRLDCWRGGQVSLKVSNDGPTLIGANASFSIALNFPGSQKVLPDGQVIWVNNTIINGSQVWGGQPVYPQETDDACIFPDGGPCPSGSWSQKRSFVYVWKTWGQYWQVLGGPVSGLSIGTGRAMLGTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQPLTFALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLTSCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTEVISTAPVQMPTAESTGMTPEKVPVSEVMGTTLAEMSTPEATGMTPAEVSIVVLSGTTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGTATLRLVKRQVPLDCVLYRYGSFSVTLDIVQGIESAEILQAVPSGEGDAFELTVSCQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKGGSGTYCLNVSLADTNSLAVVSTQLIMPGQEAGLGQVPLIVGILLVLMAVVLASLIYRRRLMKQDFSVPQLPHSSSHWLRLPRIFCSCPIGENSPLLSGQQV
Protein
Melanocyte protein PMEL: PMEL

Gene
PMEL
Protein
Melanocyte protein PMEL
Organism
Bos taurus
Length
649 amino acids
Function
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures (By similarity).
Similarity
Belongs to the PMEL/NMB family.
Mass
69.366 kDa
Sequence
MDLVLRKYLLHVALMGVLLAVGTTEGPRDRDWLGVSRQLRIKAWNRQLYPEWTESQGPDCWRGGHISLKVSNDGPTLIGANASFSIALHFPKSQKVLPDGQVIWANNTIINGSQVWGGQLVYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWDQYWQVLGGPVSGLSIGTDKAMLGTYNMEVTVYHRRGSQSYVPLAHSSSAFTITDQVPFSVSVSQLQALDGRNKRFLRKQPLTFALQLHDPSGYLAGADLSYTWDFGDSTGTLISRALTVTHTYLESGPVTAQVVLQAAIPLTSCGSSPVPGTTDRHVTTAEAPGTTAGQVPTTEVMGTTPGQVPTAEAPGTTVGWVPTTEDVGTTPEQVATSKVLSTTPVEMPTAKATGRTPEVSTREPSGTTVTQGTTPELVETTAGEVSTPEPAGSNTSSFMPTEGTAGSLSPLPDDTATLVLEKRQAPLDCVLYRYGSFSLTLDIVQGIESAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASLIYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV
Protein
Melanocyte protein PMEL: PMEL

Gene
Pmel
Protein
Melanocyte protein PMEL
Organism
Mus musculus
Length
626 amino acids
Function
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures (By similarity).
Similarity
Belongs to the PMEL/NMB family.
Mass
65.98 kDa
Sequence
MVGVQRRSFLPVLVLSALLAVGALEGSRNQDWLGVPRQLVTKTWNRQLYPEWTEVQGSNCWRGGQVSLRVINDGPTLVGANASFSIALHFPGSQKVLPDGQVIWANNTIINGSQVWGGQPVYPQEPDDACVFPDGGPCPSGPKPPKRSFVYVWKTWGKYWQVLGGPVSRSSIATRHAKLGTHTMEVTVYHRRGSQSYVPLAHASSTFTITDQVPFSVSVSQLQALDGETKHFLRNHPLIFALQLHDPSGYLAEADLSYTWDFGDGTGTLISRALDVTHTYLESGSVTAQVVLQAAIPLVSCGSSPVPGTTDGYMPTAEAPGTTSRQGTTTKVVGTTPGQMPTTQPSGTTVVQMPTTEVTATTSEQMLTSAVIDTTLAEVSTTEGTGTTPTRPSGTTVAQATTTEGPDASPLLPTQSSTGSISPLLDDTDTIMLVKRQVPLDCVLYRYGSFSLALDIVQGIESAEILQAVPFSEGDAFELTVSCQGGLPKEACMDISSPGCQPPAQRLCQSVPPSPDCQLVLHQVLKGGSGTYCLNVSLADANSLAVASTQLVVPGQDGGLGQAPLLVGILLVLVAVVLASLILGIDLRSRAQFPKCHMVALTAAPASGLRARGLGENSPLLSGQQV
Protein
Melanocyte protein PMEL: Pmel