Protein
Group 3 secretory phospholipase A2
Function
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-archidonoyl-PE. Plays a role in ciliogenesis (By similarity).
Similarity
Belongs to the phospholipase A2 family.
Sequence
MGVLVVLLGVLSFLGRTLGGSPALHWDSTSCHLARPIPGRPLRSLSFLGKDAQGLALFHAHWDGHGRLQVCSRQDEPELTAAYGALCAGEITRGSFIHTPGPELQRALATLQSQWEACRGPAESPAGTREKRAAGQNGVPGIGRQWVKRGWTVPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPHNVSPFQYNYGIRNYRFHTISHCNCDARFQQCLQDQRDSVSDIMGVAFFNVLAIPCFVLEEQEACVEWYWWGGCRRYGSVPFARLQPRTFYNASWSSPATSLTPSPQNPALSRPQPMQHPQQWPSEWKESKSPSKTNATALQAPVASPGSDRASTVQLEVTHPGFQGTTGGRKPPGAHRACRSFRHLDQCEHQIGPQETKFQLFNSAHEPLFHCNCTRRLARFLRLHGPPVGASMLWELPGMTCFKLAPPLDCAEGKGCPRDPRAFKVSARHLLRLQQRRLQLQGTGTDNGQVWPSEDQGAPISFYNRCLQLT