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PIGH

Gene
pigH
Protein
4-hydroxy-2,2'-bipyrrole-5-methanol synthase PigH
Organism
Serratia sp. (strain ATCC 39006)
Length
653 amino acids
Function
Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Carrier of the L-malonyl group (malonyl-S-PigH), which is decarboxylated by PigJ to yield a C2 carbanion acetyl-S-PigH. Then the pyrrolyl group of pyrrolyl-S-cysteinyl PigJ intermediate is captured by the C2 carbanion acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH. In the last step, PigH catalyzes the decarboxylative condensation between the pyrrolyl-beta-ketoacyl (pyrrolyl-beta-ketoacyl-S-PigH) and L-serine to yield 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM).
Mass
71.158 kDa
Sequence
MNDVTTETYETLKQSVLHTFAQLTGYNVSELSLTSHLENDLGVDSIALAEIAVSLSRQFQLNTPLLIQDINTIKDALDGILQREFQLSEKVEPAAIALSGDADLWLGNLVRQIFASHSGYDVNALALDAEIESDLGIDSVSVASAQGELFNTLQLNSETIIANCNTLSALKQCLAARLVQEKGQDWFEQRGRGQSDSAIDHDADTTAEVTPPTATPVAINAEIGDPRTMRDFVGIEHPDIFHKAREFHLFYQDKKKRQLYFYGMPLETPCKNRAVMFDEATGQHREFLMFGSNSYLGLSNHPEIIHAIQDAASLYGATNTGCRIIAGSNVLHLELERKLAKLKGRDDCIVYPSGYSANLGCISALTSRHDLVFTDAINHMSIQDGCKLAGAQRKIYNHSLTSLEKSLAKYADHPGGKLIVTDGVFSMHGDIVDLPRLMKLAERYGARVLVDDAHSTGVLGKTGAGTSEHFNMKGQVDLELGTMSKALSGLGGYVCGDGDVVEYLRFYSNSYVFAATIPAPVAAGVIASIDVMLREPERLAKLWDNIYYFRTRLLNAGFDLENSDSAIIPIVVGDDAKTLFFGRAVRARGMFCQTVVFPGVSVGDARLRISITSEHTREDLDEAYAILVASALEVGVPVNASAHQEENASVAEA

Gene
PIGH
Protein
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
Organism
Bos taurus
Length
188 amino acids
Function
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Similarity
Belongs to the PIGH family.
Mass
21.006 kDa
Sequence
MEDERSLSDICGGRLALHRRYYSPSCLEFCLSCPRISLRSITAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDHETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDVIINEAIYMQKVIYYLCILLKDPVEPHGISQVVPIFQSAKPRLDCLIEVYRSCQEILAHQKAASTSP

Gene
PIGH
Protein
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
Organism
Homo sapiens
Length
188 amino acids
Function
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Similarity
Belongs to the PIGH family.
Mass
21.081 kDa
Sequence
MEDERSFSDICGGRLALQRRYYSPSCREFCLSCPRLSLRSLTAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDQETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDIVINEAIYMQKVIYYLCILLKDPVEPHGISQVVPVFQSAKPRLDCLIEVYRSCQEILAHQKATSTSP

Gene
Pigh
Protein
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
Organism
Mus musculus
Length
188 amino acids
Function
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Similarity
Belongs to the PIGH family.
Mass
21.078 kDa
Sequence
MEDEKSFSDICGGRLALRCRYYSPYCREFGLSSARLSLCSLTAVTCAVWLAAYGLFTLCENSMVLSATIFITILGLLGYLHFVKIDQETLLIIDSLGIQMTSSYASGKESTTFIEMDKVKDIIINEAIYMQKVIYYLCILLKEPGKPHEISRVVPVFQSAKPRLDCLIEVYRSCQEVLAHQKATATSL