Pidd1

p53-induced death domain-containing protein 1

915 amino acids

Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity).

101.141 kDa

MAAVLEGQEPEETAAAAEDAATSTLEAVDAGPGAPFLPAGNQLNLDLRPGGCHRLQYLCSQQPPQLLQVEFLRLSTHEDPQLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPAGLSDLACLAHLDLSFNRLETLPTCVPELHGLDALLLSHNHLSELPEALGALPALTFLTVTHNRLERLPLTLGSLSTLQRLDLSENLLDTIPSEIGNLRSLSELNLASNRLQSLPASLAGLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDLRDNRLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLLLTSDLDSFLVTPHGCSVTLACGVRLQFPAGATTTPVTIHYRLWLPEPGLVSLGPHDFLLSSVLELQPHGVAFQQDVSLWLLFVPPRVRRCREVVVRTRSNNTWNDLETQLEEEAPKRLWARCQVPHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLTTTWDDITTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLSRLLVRYRGPEPSETVEMFEGEKFFAAFERGIDVDADRPDCVDGRICFVFYSHLKNVKEVYITTALDREAQDVRGQVSFYRGSLPVEVPAEAEAARQRKGTDALWMATLPIKLPRLRGAQGSGQGTDFSLMPLNLGDAETGFLTQSNLLSVASRLGPDWPAVALHLGMPYHKLQRIRHEFRDDLDGQVRHMLFSWAERQTGQPGAVGHLVQALEQSDRRDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPGTSASQTPESAQA

PIDD1

p53-induced death domain-containing protein 1

910 amino acids

Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900).

99.712 kDa

MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA