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PHF10

Gene
phf10
Protein
PHD finger protein 10
Organism
Xenopus laevis
Length
506 amino acids
Function
Involved in transcription activity regulation by chromatin remodeling in the context of the neural progenitors-specific chromatin remodeling complex (npBAF complex). May play a role in the proliferation of neural progenitors (By similarity).
Similarity
Belongs to the SAYP family.
Mass
57.328 kDa
Sequence
MAAVVSAKPLCDSEPAIPAPPSVKEDNSNDTKDPEENSNDGSQPAKRRRMSGDSTPSCENSNQDFGSSYFPAENVIEYKWPPDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQLQQQNTQKVEAGKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHIIQVPQGKYKILPSEMTKVSPYPVSLIPGQFQEYYKRYSPNELRYLPLNTALYEPPLDPLDPELLALDSDGDSDEVEEMKSEKKKTKGSSVRLSIDSSSMNMSESDNTQDTQEETPQPRPKVKEKSSTPRKEGSKRSVLSKSVSGYKPKSIPNAICGICLKGKDANKKGRSERLIHCSQCDNSGHPSCLDMSAELVAVIKKYPWQCMECKTCIICGQPHHEEEMMFCDTCDRGYHTFCVGLGALPSGRWICDCCQKVPATPKKGARKVKNSKEG

Gene
PHF10
Protein
PHD finger protein 10
Organism
Homo sapiens
Length
498 amino acids
Function
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Similarity
Belongs to the SAYP family.
Mass
56.051 kDa
Sequence
MAAAAGPGAALSPRPCDSDPATPGAQSPKDDNEDNSNDGTQPSKRRRMGSGDSSRSCETSSQDLGFSYYPAENLIEYKWPPDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQNTQKVEASKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHVIQVPQGKYKVLPTERTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLDPELPALDSDGDSDDGEDGRGDEKRKNKGTSDSSSGNVSEGESPPDSQEDSFQGRQKSKDKAATPRKDGPKRSVLSKSVPGYKPKVIPNAICGICLKGKESNKKGKAESLIHCSQCENSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDMCDRGYHTFCVGLGAIPSGRWICDCCQRAPPTPRKVGRRGKNSKEG

Gene
Phf10
Protein
PHD finger protein 10
Organism
Mus musculus
Length
497 amino acids
Function
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Similarity
Belongs to the SAYP family.
Mass
55.84 kDa
Sequence
MTAAGPGAAPSPGRCDSDPASPGAQSPKDDNEDNSNDGTHPCKRRRMGSGDSSRSCETSSQDLSFSYYPAENLIEYKWPPDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQSTQKVEASKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHVIQVPQGKYKVLPTDRTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLDPELPALDSDGDSDDGEDGGGDEKRKNKGTSDSSSGNVSEGDSPPDSQEDTFHGRQKSKDKMATPRKDGSKRSVLSKSAPGYKPKVIPNALCGICLKGKESNKKGKAESLIHCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFCVGLGAIPSGRWICDCCQRAPPTPRKVGRRGKNSKEG

Gene
Phf10
Protein
PHD finger protein 10
Organism
Rattus norvegicus
Length
497 amino acids
Function
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Similarity
Belongs to the SAYP family.
Mass
55.884 kDa
Sequence
MAAAGPGAALSPRRCDSDPASPGAQSPKDDNEDNSNDGGHPSKRRRMGSGDSSRSCETSSQDLSFSYYPAENLIEYKWPPDETGEYYMLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQSTQKVEASKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHVIQVPQGKYKVLPTDRTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLDPELPALDSDGDSDDGEDGGGDEKRKNKGTSDSSSGNVSEGDSPPDSQEDTFQGRQKSKDKMATPRKDGSKRSVLSKSVPGYKPKVIPNALCGICLKGKESNKKGKAESLIHCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFCVGLGAIPSGRWICDCCQRAPPTPRKVGRRGKNSKEG

Gene
phf10
Protein
PHD finger protein 10
Organism
Danio rerio
Length
490 amino acids
Function
Involved in transcription activity regulation by chromatin remodeling in the context of the neural progenitors-specific chromatin remodeling complex (npBAF complex). May play a role in the proliferation of neural progenitors (By similarity).
Similarity
Belongs to the SAYP family.
Mass
55.184 kDa
Sequence
MAAVLSPRPCDSNPATPGTQSIKDDIEENSSDGSQAPKRRRMGSGDSSRSCDTSTHELGPTYFPAENLTEYKWPPDDTGEYYMLQEQVSEYLGVTSFKRKYPEMERRDLSHKEKLYLREQNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQERERQRITKEYNVSTLSVQMQQQNPQKVEASKVPEYIKKAAKKAAEFNSNFNRERMEERRAYFDLQTHIIQVPQGKYKILPPERTKTGPFPVALIPGQFQEYYKRYSPNELRYLPLNTALFEPPLDPELPALDSDGDSDDGDDGKEDGKKNKGSSDSSSGNTSDGDSQDSGIHSKVKSKDRPGAQGKDGTPRSIQHKSVPGYKPKVIPNAICGICQKGKEANKRGKPEALIHCSQCQNSGHPSCLDMSVDLVAKIKMYPWQCMECKTCTVCQQPHHEEEMMFCDKCDRGFHTFCVGMDSIPMGCWVCDLCSKDISTPQKKGQTKTPKKAK

Gene
PHF10
Protein
PHD finger protein 10
Organism
Bos taurus
Length
410 amino acids
Function
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Similarity
Belongs to the SAYP family.
Mass
46.437 kDa
Sequence
MLQEQVSEYLGVTSFKRKYPDLERRDLSHKEKLYLRELNVITETQCTLGLTALRSDEVIDLMIKEYPAKHAEYSVILQEKERQRITDHYKEYSQMQQQNTQKVEASKVPEYIKKAAKKAAEFNSNLNRERMEERRAYFDLQTHVIQVPQGKYKVLPTERTKVSSYPVALIPGQFQEYYKRYSPDELRYLPLNTALYEPPLDPELPALESDGDSDDAEDGRGDEKGKSKGTSDSSSGNVSEGEGLPEGQEEPLPGRQRPRDKAAAPRKDAPKRSALSKAVPGHKPKVIPNALCGICLKGKESSRRGKAEPLVHCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFCVGLGAIPSGRWICDCCQRAPPTPRKVGRRGKNSKEG