About Products Protein Database Contact

PHACTR4

Gene
PHACTR4
Protein
Phosphatase and actin regulator 4
Organism
Gallus gallus
Length
720 amino acids
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Similarity
Belongs to the phosphatase and actin regulator family.
Mass
79.686 kDa
Sequence
MGQPRFSRPVHPAAAAEEVDHPPSDAGMGVDVLESGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQALSSDCPGKEGSVLRKSIILISHFRDAETPGQSEDDGGRLLYLQFQNLLLREGKEAAWPWHQAECIPVEQQVPPLGIKLTRGLFPSAGKSQGRAAEHPGLGLTSCVLLSTSILSAPANVSAGAFLVSFLSLVCNCSEALRAPGGEAVTLLTDTXEVTNQAQPPCQTAPCPPHPIPTNRNSSSVIAELSQAINSGTGLSKPSPPLPPKRGLLPTNPPEAALPSKPPGDRTVTASRPTLLPMHVAPTYPPPSPSPPLPTHIPPEPPRMPLPNSTPALDAPRSLDLPKETPPPSKDFRSLEVSKRTAEQGFGEPPGLPRLPQIPLHIRIQQALASPLPVTPPADGSHRAHSLLFENDGFGEDNGTLGRTRSLPVTIEMLKVPDDEEEEEEDQEEEQNSGPRVYIGDVPSITVIPMLVPQVLPEEQEGEEGMSDSDSEGPILYKDDEEDEEEDESHNSTLANKVKRKDTLAIKLGNTTTVQEEKIVFPRKSKEEWNEIRQQIGTTLIRRLSQRPTAEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELQARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSCEMEVHEESKQFTRYHRP

Gene
PHACTR4
Protein
Phosphatase and actin regulator 4
Organism
Bos taurus
Length
712 amino acids
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Similarity
Belongs to the phosphatase and actin regulator family.
Mass
78.821 kDa
Sequence
MGQADISRPVNPDGVEEIGQPTADLGMVMDCVEAGDITPPTKRKSKFSGFGKIFKPWKWRKKKSDKFKETSEVLERKISMRKPREELVKRGLLLEDSEQGGEDPGKLSHATLKNGHTTLIGSTRSSSPVQVEEESERIASLRKPVPEEEPKKRLGSSGSQPHSEAEFVPESIPKQPLLPPKRHLSSSHEANEGQAKDATSSGSLARPSSSASTTAITTAPAATMAATNPAKTVHSSGPPSQAPRTLPAAPASTHTTATLSLTHTGPAKQPPIPPPKPTHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSALVPTSESAAATTATKAPSDQREKSACSVGSEPLLTPSSSPLPAHIPPEPPQSPPFPAKTFQVVPEIEFPPSLDLPQEIPQQESQKREVPKRMLDHSFGEPQVPPRLPPVPLHIRIQQALTSPLPVTPPLEGSHRAHSLLFENSDNFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQSHIFAFDEDVASTSVIPKLPQCLQEEEEGKESDSDSEGPIQYRDEEDEDESHHSALANKVKRKDTLAMKLNHKPSEPEMNMNSWPRKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAHDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEDSKHFTRYHRP

Gene
phactr4
Protein
Phosphatase and actin regulator 4
Organism
Xenopus tropicalis
Length
706 amino acids
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
Similarity
Belongs to the phosphatase and actin regulator family.
Mass
78.224 kDa
Sequence
MPSAPSTPPSKRKSKFAGFGKFFKPWKWRKRKSSDSFRETSEVLERKISMRKPREELVKRGLLVEVPEEDVSIPSESPPLRNGHMSVEHANPPEDIGGLKRKTRQDSTGSRPKSGETTVQPCATAEVAPVEPCTATEVASVQPHATAEVAPIQPLATAEVSPVQHCATAEVAPVQPRPVSEVASVQPCPVSEVVPVHPRHLSEKNSEKYRPMSEVAPGASRPTSEVAPLQKVSRDFSKQPLLPPKRPLSSSSSVTQESVLGGQKPDPSTRQQSSVPVPTPRTIHPLPFSKQPPVPPPKPQNRSSNPLMAELSLALGGSTLSPAGSRPSPPIPPKRVVVPSTDAVNNKEKALRPASLPPIPANEISIPSPPSPPISSHIPVSNPPVPMLTLAPPNTEVEKEQSASPLPLHIRIQQALNSPQPLPLLDSSQRAQSLLFMQNEVPSEEGTRVRSLPVTIELLKVPDDDDDDNSLEDESLSPESSESHPSRVYIGDVPSVTVIPNYLPTCVQEEEEEEEEGVSDTDSEGPVLYREDDEEEEEEETSSLANKVKRKDTLAMKLSGRMGPHDSNPEFPQRSREEWNQIRQQIGSQLNRRLSQRPSAEELEQRNILQKNEADRLAEKKEIKRRLTRKLSQRPTVAELVERKILRFNEYVEVTDAHDYDRRADKPWTRLTPADKAAIRKELNEFKSTEMAVHEESKHFTRFHRP

Gene
PHACTR4
Protein
Phosphatase and actin regulator 4
Organism
Homo sapiens
Length
702 amino acids
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Similarity
Belongs to the phosphatase and actin regulator family.
Mass
78.211 kDa
Sequence
MEDPFEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP

Gene
PHACTR4
Protein
Phosphatase and actin regulator 4
Organism
Pongo abelii
Length
702 amino acids
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Similarity
Belongs to the phosphatase and actin regulator family.
Mass
78.11 kDa
Sequence
MEDPFEEADQPATEPGMVMDSVEAGDTTPPTKRKSKFSGVGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSHAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIQFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPVTPTLEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQICPSTFSEETTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP

Gene
Phactr4
Protein
Phosphatase and actin regulator 4
Organism
Mus musculus
Length
694 amino acids
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.
Similarity
Belongs to the phosphatase and actin regulator family.
Mass
76.632 kDa
Sequence
MEDPSEEAEQPSGDPGMGMDSVEAGDTTPPTKRKSKFSALGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQDGEDSGKLSHAALKNGHTTPIGSARSSSPVLVEEEPERSLRNLTPEEESKKRLGSTGSQPNSEAEPGPEHAPKQPLLPPKRPLSSSCEAKEVPAGSTARSVSSTSGSTTVTSAATTAATDMTKTVKSFVGPTPAPAPAPRTLPAAPASANTAATTTAPAKQPPIPPPKPAQRNSNPIIAELSQAMNSGTVLSKPSPPLPPKRGIPSTSIPSLEPAASFTTKTANDQREKTVSLCLEPPLIIPPSSPSPPLPTHIPPEPPRSPLVPAKTFQIVPEVEFSSSSDLFQDISQQEDQKTEVPKKIQDQSFGESHIPSRLPPLPLHIRIQQALTSPLPVTPPLEGTHRAHSLLFENSDSFSEDTGTLGRTRSLPITIEMLKVPDDEEEEQTCPFVEDVTSTSATPSLPLCLREEEKESDSDSEGPIKYRDEEEDDDDDESHQSALANRVKRKDTLAMKLSSRPSEPETNLNSWPRKSKEEWNEIRHQIGNTLIRRLSQRPTAEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAHDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHVDSKHFTRYHRP