Protein
Polyribonucleotide 5'-hydroxyl-kinase PH0197
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Function
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.
Sequence
MLTEVCKMGTNKAFFTNEVPEDRYIAAEKISSLKKPATVMIIGDVDTGKTTLTIYLANELISRGFRVSIIDSDVGQKSILPPATISLAFVDTHFSSLEDLTPFAHYFVGTITPSQFFGEMVIGVMKLAELAKKFSDVVLIDTTGMIYGPGVELKRMKIEAIKPDLILALERENELTPIIKGFEDITLKLRVSDKVKEFSRSERKELRREKWKRYFENSRIVTFNVNDILVTGTSMFQGKPIEEGEKNLLERLFKWLILHGRKLGERYFVVKVDTSEGPRVVDKNVVRYFDFSKLSNLLLGLLDKEGFCQGVGILKAINFSEGRLEVLTPVKDISIITEIRFGRIRVREDGEELGLLDREVL