Protein
Peptidoglycan-recognition protein SD
Organism
Drosophila simulans
Function
Peptidoglycan-recognition protein that plays a key role in innate immnunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN (By similarity).
Similarity
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Sequence
MTWIGLLIVGLTAIAVQGEVPIVTRAEWNAKPPNGAIDSMETPLPRAVIAHTAGGACADDVTCSQHMRNLQNFQMSKQKFSDIGYHYLIGGNGKVYEGRSPSQRGAFAGPNNDGSLGIAFIGNFEKQAPNKEALDAAKELLEQAVKQAQLVEGYKLLGHRQVSATMSPGEALYALIQQWPNWSEEM