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PF4

Gene
Pf4
Protein
Platelet factor 4
Organism
Mus musculus
Length
105 amino acids
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity).
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
11.243 kDa
Sequence
MSVAAVFRGLRPSPELLLLGLLFLPAVVAVTSAGPEESDGDLSCVCVKTISSGIHLKHITSLEVIKAGRHCAVPQLIATLKNGRKICLDRQAPLYKKVIKKILES

Gene
Pf4
Protein
Platelet factor 4
Organism
Rattus norvegicus
Length
105 amino acids
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
11.287 kDa
Sequence
MSAAAVFRGLRPSPELLLLGLLLLPAVVAVTRASPEESDGDLSCVCVKTSSSRIHLKRITSLEVIKAGPHCAVPQLIATLKNGSKICLDRQVPLYKKIIKKLLES

Gene
PF4
Protein
Platelet factor 4
Organism
Homo sapiens
Length
101 amino acids
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
10.845 kDa
Sequence
MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES

Gene
PF4
Protein
Platelet factor 4
Organism
Sus scrofa
Length
90 amino acids
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
9.644 kDa
Sequence
QEWSLPGTRVPPPADPEGGDANLRCVCVKTISGVSPKHISSLEVIGAGPHCPSPQLIATLKKGHKICLDPQNLLYKKIIKKLLKSQLLTA

Gene
PF4
Protein
Platelet factor 4
Organism
Bos taurus
Length
88 amino acids
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
9.523 kDa
Sequence
ESSFPATFVPLPADSEGGEDEDLQCVCLKTTSGINPRHISSLEVIGAGTHCPSPQLLATKKTGRKICLDQQRPLYKKILKKLLDGDES

Gene
PF4
Protein
Platelet factor 4
Organism
Ovis aries
Length
85 amino acids
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
9.13 kDa
Sequence
XSSLPAASVSLPADSEGGEEEDLQCVCLKTTSGIHPRHISSLEVIGAGLHCPSPQLIATLKTGRKICLDQQNPLYKKIIKRLLKN

Gene
PF4
Protein
Platelet factor 4
Organism
Oryctolagus cuniculus
Length
30 amino acids
Function
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity).
Similarity
Belongs to the intercrine alpha (chemokine CxC) family.
Mass
3.318 kDa
Fragment
single
Sequence
SDDPKESEGDLHCVCVKTTRLVRPGHITXL