Protein
tRNA (uracil(54)-C(5))-methyltransferase
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function
Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Sequence
MRGIIKRLNDDGFGILYNKILVPFSAPGDEVEVLKTEKQKRAKIATEWRLLRSSPIRVGARCKVFGKCGGCILQHINYNSQLEFKKEKLRKILGREVEIIPSPRIFGHRNRIDLAVTVNAIGFREKGKWWSVVDVEECPVFGKTSKKAIERLREYIEEEKVSTWKIREDSGFLRYMVLREGKFTGEIMVNFVTKEGELPDPTSYFDFADSIYWSINRSKSDVSYGDIEKYWGKEFIMEELDGVKYLIHPNSFFQTNSYQAVNLVKTVEKFVEGEKVVDMYSGVGTFGVYLAKKGMKVVGFDSNAFAIEMANKNAEINNVEAEFFVASDREVDIKGFDTVIVDPPRAGLHPKLVKRLNDHGPETIVYVSCNPKTFKVNIEQLNNYIIEELIALDMFPHTPHIELVGKLRRLV