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PERM1

Gene
PERM1
Protein
PGC-1 and ERR-induced regulator in muscle protein 1
Organism
Bos taurus
Length
901 amino acids
Function
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4 (By similarity).
Mass
94.21 kDa
Sequence
MENFQYSVQLSDQDWAEFSAAAEECGLLQAGLASGDEPLSSDTDQRDSRGSSPPGPSPFLEGQLTPGGSSWPSFEEEDKAATRQLVSRSWHEPMLAPEAGQQTPSTSAQSEARLSLSPGATPLVQGSSLPGPVSSRDEMQRLLRGPAPRGPAPTPTGEPAGSPESPVHSAAPQRSPGSPGAPPRSPGRKKRRTAGTKAGGRSGGPGPAPTQLDSPLLTEAKPEDSFGPAGSRGKGLPAGAAKQTAGTGPESAGAPEQVAGQGPGVDLSTSVSTTEQGTDRLGMSPRADPCAASTSDPGAPLDVTIKSDVALSTPASEPQPDKPQSTPAFKPQPDEPQSTPAFKPQPDESQSTSAFNAQPNEPQSTPTFSPQPDEPQSTPAFKPQPDEPQSTSAFNAQPNEPQSTLAFSPQPDEPQSTPAFKPQPDEPQSTPAFNVQPNEPQSTPAFSPQPNEPQSTPAFKPQPDEPQSTPAFNTQPNEPQSTPTFKPRLDVDQLMPGPVVQPEVDSSMPASKAVPCTALPHLVLEAGSDVGVSTPPAPTPQAGPDMVEAEVVPVAKLGLSPVRSLEGHQQNPRGEPSTDAPGHHTGEPPLGPIQAPKKKKVRFSMAMPSSEEPGSGEVSGPLSPATAPRMASGGHRGSGAWDSVAVGPRSPQPRILKHLPPPAPSASMGPGRRSCFAVTLPEAYDFFFCDTIEEEDEEAEGAAEAAQAPAEVQWPDVCEFFFQESQIQRSRHQEGRSQAPLLKAGSVPAPPPGDPMPISIPEAYEHFLEEDRSGGTLGPAALLQMQATEPSRSVLWGVGTGAPPESSPATVEQLTLAIREAVAPRGPLTSFTFSQKDMCMVFVAFATWAVRTSDLHAPDAWKTVLLANIGTISAIRYFRRQVERGRHSRSRSPSPSSSPSP

Gene
Perm1
Protein
PGC-1 and ERR-induced regulator in muscle protein 1
Organism
Mus musculus
Length
807 amino acids
Function
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
Mass
85.157 kDa
Sequence
MDNFQYSVQLSDREWAEFSATADECGLLQADLASGDEPLSSDIDQGDSSGSSPPGPPPLFTGQLVSQGRGQQSRELEDVAAQQLVSRSQCEPVLALEASHQVAGTSTQSEAPLFPSLDSVCPGQALSFPGPATCRDKMQRLLQGPAPSSPSKAPHSPESPGHSDNPQSSPDSLEASPRNPGRKKRRAVGAKGTKHSGSLDSAATQMSSPQLTRPKEALMSGTLMAKAQQDKPQPDSTSPEQMAREESGLDLSTPILITEQDQIRKTSRAALHVVSKPVQEVHPDVPMASPNVSTRASKPQPDVALPKPASKPQSDIASSTHPFTPDVSLSTLAFKCQPNTNQSTPASEPDMALSTPASEPDTALSTPASEPDTALSTPASEPDTALSTPASRSQLVKAEFASACTPGLHVDLSAAGSEIKPEVSSSMPAAVDVLRTDLPRSVSKTESKESVSIPVKPSLSPISQAEAAMVDTGVSVPPGGSIEKPAGQFSAGSSGESCLGPVQAPKKKKVRFSMAIPSHEDSGSGEPTGSPFLTPEQPPVPRTAAGSRGGSAAWDAVAVAPRLPQPRILKHLPPPVSSVSAEAESGNCFAVTLPEAYEFFFCDTIEEEDEDVEDEEAASQALDEVQWPDTCEFFFRDSRAQRSRCQRGHSPVSPPRADTVAPVPPEGLVPISIPEVYEHFFTEEGFGHRQPAATPMQTSELSREGGLEASTKPVSPTAEHLSLTVRKAGELRSPLTSFTFSQNDMCLVFVAFATWAVRTSDLQAPDAWKTVLLANIGTISAIRYFRRQVGRGHSGRPRSSSSSNPSC

Gene
PERM1
Protein
PGC-1 and ERR-induced regulator in muscle protein 1
Organism
Homo sapiens
Length
790 amino acids
Function
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
Mass
81.351 kDa
Sequence
MENFQYSVQLSDQDWAEFSATADECGLLQAGLASGDELLSSDIDQGDSSGSSPPRAPPLPTGQLAAGGRSRRGCEEEDVATQQPVSRSQGEPVLALGTGQQTPSTSARAEAPPSLGPGASPPSQFSSCPGPASSGDQMQRLLQGPAPRPPGEPPGSPKSPGHSTGSQRPPDSPGAPPRSPSRKKRRAVGAKGGGHTGASASAQTGSPLLPAASPETAKLMAKAGQEELGPGPAGAPEPGPRSPVQEDRPGPGLGLSTPVPVTEQGTDQIRTPRRAKLHTVSTTVWEALPDVSRAKSDMAVSTPASEPQPDRDMAVSTPASEPQSDRDMAVSTPASEPQPDTDMAVSTPASEPQPDRDMAVSIPASKPQSDTAVSTPASEPQSSVALSTPISKPQLDTDVAVSTPASKHGLDVALPTAGPVAKLEVASSPPVSEAVPRMTESSGLVSTPVPRADAAGLAWPPTRRAGPDVVEMEAVVSEPSAGAPGCCSGAPALGLTQVPRKKKVRFSVAGPSPNKPGSGQASARPSAPQTATGAHGGPGAWEAVAVGPRPHQPRILKHLPRPPPSAVTRVGPGSSFAVTLPEAYEFFFCDTIEENEEAEAAAAGQDPAGVQWPDMCEFFFPDVGAQRSRRRGSPEPLPRADPVPAPIPGDPVPISIPEVYEHFFFGEDRLEGVLGPAVPLPLQALEPPRSASEGAGPGTPLKPAVVERLHLALRRAGELRGPVPSFAFSQNDMCLVFVAFATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQVGQGRRSHSPSPSS