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PDCL

Gene
PDCL
Protein
Phosducin-like protein
Organism
Bos taurus
Length
301 amino acids
Function
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
Similarity
Belongs to the phosducin family.
Mass
34.395 kDa
Sequence
MTTLDDKLLGEKLQYYYSSSEEEDSDHEDKDRGRGALAGSSMPADADLAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSLSCRSHLDEEEEQRKQKDLQEKISGKMTLKDLAVMNEDQDDEEFLQQYRKQRMEEMRQQLYQGPQFKQVFEIPSGEGFLDMIDKEQRSTLIMVHIYEDGIPGTEAMNGCMLCLAAEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKGGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLLRTSVRNSATCHSEDSDLEID
Protein
Phosducin-like protein: PDCL

Gene
PDCL
Protein
Phosducin-like protein
Organism
Homo sapiens
Length
301 amino acids
Function
Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
Similarity
Belongs to the phosducin family.
Mass
34.282 kDa
Sequence
MTTLDDKLLGEKLQYYYSSSEDEDSDHEDKDRGRCAPASSSVPAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMTCRSHLDEEEEQQKQKDLQEKISGKMTLKEFAIMNEDQDDEEFLQQYRKQRMEEMRQQLHKGPQFKQVFEISSGEGFLDMIDKEQKSIVIMVHIYEDGIPGTEAMNGCMICLAAEYPAVKFCKVKSSVIGASSQFTRNALPALLIYKGGELIGNFVRVTDQLGDDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID
Protein
Phosducin-like protein: PDCL

Gene
Pdcl
Protein
Phosducin-like protein
Organism
Mus musculus
Length
301 amino acids
Function
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers (PubMed:23637185). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584).
Similarity
Belongs to the phosducin family.
Mass
34.407 kDa
Sequence
MTTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPAISSTPAEAELAGEGISINTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEEEEQQKQKDLQEKISGKMTLKEFGTKDKNLDDEEFLQQYRKQRMEEMRQQFHKGPQFKQVFEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLATEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID
Protein
Phosducin-like protein: Pdcl

Gene
Pdcl
Protein
Phosducin-like protein
Organism
Rattus norvegicus
Length
301 amino acids
Function
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
Similarity
Belongs to the phosducin family.
Mass
34.274 kDa
Sequence
MTTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPASSSTPAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEEEEQQKQKDLQEKISGKMTLKECGMMDKNLDDEEFLQQYRKQRMDEMRQQLHKGPQFKQVLEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLAAEYPTVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID
Protein
Phosducin-like protein: Pdcl