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PCLAF

Gene
pclaf
Protein
PCNA-associated factor
Organism
Xenopus tropicalis
Length
125 amino acids
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
Mass
12.885 kDa
Sequence
MVRTKADSAGSSASSGSYRKAVAARAPRKTFGSSSSGSNHVTSPTGKKSESKYAGGNPVCVRPTPTWQKGIGEFFGSPSTSQPEKENRIPSDDEEAGGSGAGKAPRKSRPLPPDPSEEAADSDDE

Gene
pclaf
Protein
PCNA-associated factor
Organism
Xenopus laevis
Length
123 amino acids
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
Mass
12.772 kDa
Sequence
MVRTKADCAGSSSGSYRKAVAARAPRKTFGSSSSGSNHDTSPTGKKSECKYAGGNPVCVRPIPTWQKGIGDFFGSPSTSQPEKENRIPSDDEEAGGSGAGKKPRKSRPLPPDPSEEAADSGDE

Gene
PCLAF
Protein
PCNA-associated factor
Organism
Bos taurus
Length
111 amino acids
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
Mass
11.91 kDa
Sequence
MVRTKANSVPGSYRKVVASRAPRKVLGSSTSAANSTPLSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFSLSPKDSEKENRIPEEAGSSGLGKAKRKACPLPPDHTDDEKE

Gene
PCLAF
Protein
PCNA-associated factor
Organism
Homo sapiens
Length
111 amino acids
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Mass
11.986 kDa
Sequence
MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSEKENQIPEEAGSSGLGKAKRKACPLQPDHTNDEKE

Gene
Pclaf
Protein
PCNA-associated factor
Organism
Mus musculus
Length
110 amino acids
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
Mass
11.993 kDa
Sequence
MVRTKANYVPGAYRKAVASQAPRKVLGSSTFVTNSSSSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKESKKENQAPEEAGTSGLGKAKRKACPLQPDHRDDENE

Gene
Pclaf
Protein
PCNA-associated factor
Organism
Rattus norvegicus
Length
110 amino acids
Function
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
Mass
12.006 kDa
Sequence
MVRTKANYVPGAYRKVVASQAPRKVLGSSTFVTNSSGSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSKKENQIPEEAGSSGLGKAKRKACPLQPDHRDDENE