Protein
Proprotein convertase subtilisin/kexin type 5
Organism
Branchiostoma californiense
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways.
Similarity
Belongs to the peptidase S8 family.
Sequence
MPPAIVILALFTAALCAVNLRTVAADGPRIYRNEWALHVEGGTAAADRLASKHGFINKGQIGSLEDHYLFVHRRTWKRSLRSSSHRHALLQREPEVRWLQQQVVKRRVKRRVKRVYSMYPWEQRVQHSSPQVNNPAQQDNLWDPHFNDEKWDKMWYLHCDRPEFACQWSDMNVEAAWKKGYTGKGVVVSILDDGSETDHPDLAGNYDPDASSDINGGTLDPTPRYEYTNENRHGTRCAGEVAAMGNNSFCSVGVAYKASIGGVRMLDGDVTDSVEAASLGLNPQHIMIYSASWGPDDDGKTVDGPANLAQKTFQAGAENGRDKLGSIFVWASGNGGRTHDSCGCDGYTNSIYTISVSSASEQGKVPWYLEPCASTLATTYSSGAPHERKVITTDLRKGCTESHTGTSASAPMAAGILALALEANPMLTWRDMQYIVVMAANPSPLDRDTESAYPRDPRKESDFVTNGAGLRVSHNFGFGLMDAGKMVELAESWRRVPEQHVCEEDPNAQQRAITKGETIVDTKTTGGCNGTDHHVKYLEHVVVEISLDHPCRGHLSIHITSPSGTRSTLLPERQFDSSSDGLKDWAFMTTHCWGEQPEGDWILEVKDLGQQNCQRYGLRTVLPVLRKWKLILYGTAEHPLYKRDEESRPHTPQTREEPTDEEECEDGDYYDRSKQRCRHCHDSCATCHGRHSGQCLSCHEGNYFVEDEGTCSEECGQGYYKDEEERKCLDCSADCLTCQVSADHCTSCDDEDGLKLFENTCVAQCSEGRYMDENDVCQDCDDSCDTCTGPDATDCVTCADEDLLQESQCVESCSSGYFQQEYECLKCHATCASCSGSRDDQCLTCSGHLELDEDTHRCITSCEDGEYGTEEGKCEDCNIICKKCNGSQADQCLECHHDTNLYDTTCVQYCGNRRYPENGECHPCHPSCLGCIGGEINQCNQCITDYEGEDHFLYQGTCHVTCPPGLYGDTTDQVCKACAPGCIACDGPADNQCTLCEEERAPTDGRCQSEGSQTDEAECAEGCHSCEEGPDICDSCDEDYYLTEDTCVRRTNCPSFTYPDDQDRECRPCHDNCEACDGPNNQNCNSCKEGFYKTPDGCSTGCPNRYYKDDTNKECKPCDSSCFTCSGPASFHCLSCADGDFLHESSCRSTCPAGFIGNAESHECVESSCEQDQYYSSETGRCEDCPYNCRACDNDGDCAECAPTYIVVDGRCRPEETCEDGEYQDRDRDTAELSCRPCHQSCKTCSGPSDTDCDSCKGDDTILDRGECITSCGPGEYMDRREKKCKACHPTCKECSDEYDDTCTACNDGFLLTDASSCEAGCPPGQFLHHGDCDSCHRECKTCDGPHHDNCLSCQPGSYLNDQQCSTHCPEGTFEETYEDDSGETVLQCRLCHVNCKTCHGEGEEDCMECANDIKYKQDGRCVTECQEGHYPDLTNECQQCWSDCETCDGPRNDQCVTCPYNYYLVLGKCLEDCPEGYYDTMRQEKECGECHPSCATCNEGGNYNCLSCPYGSKLGEGVCYPMCEEHEYYVEKTQICEECDNSCKTCRGSTAHDCLSCEAPYGYHAMKHLCTACCEEGSPENEYCCICHESTRLCITDREAEGVQFSSADSIPTNVAYIAVATFICVVIVVLFFVVFGMLQARSNGRLCWAHKYQQVPTTRYEKMNDHVNILSQEDFYNEDSLSEDEIHSIDSTRH