PARPBP

PCNA-interacting partner

582 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity).

Belongs to the PARI family.

65.429 kDa

MAGLNQKSILDMIKEFRRNWHTLCNSERTTVCGADSMLLALQLSMAENNKQHSGEFTVSLSDIILTWKYFLHEKLNLPVENIKVIDHYEDIRKIYDDFLKNSNMLDLIDVYKKCSDLTSNCENYANISPSRLLDFLSGREYAVDDETDFSEPVSPMSKHNQENEKVQLLAKKIIYSYLNLLVNSKNDLALAHILNIPDRGLGREAFTDLKHAAREKQMSIFLVATSFIRTIELGGKGYAPSPSDPLRAHIKGLSNFINFIDKLDEILGEVSNPSIAGGRILSVIKMQLIKGQNSRDPFYKAVEEVAQDLDLRIKNIINSQQGDVALSTTDISPARPKSHTINHGTAYCGRDTVKALLVLLDEEAASAPTKNKAELLYDNENTIHPNGTSVLTLFRCRSPTQVDNSPMKPLRERIYKSMEEKKIKMKQTSIRSQFACTYKDDCMISKDKWNNVNSASEPLCVLHMENDLSEGVNSSVGRPTIGTSSGNVHLGRSEKEKVARKSSSLTGNTSSKRKQVDLDDENILCDNGNEPLQHKIVKIPKTSKDLQNKLDGKLLRVAKSNRCTTKDKLITGQTKLTQFFRL

PARPBP

PCNA-interacting partner

580 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability.

Belongs to the PARI family.

65.151 kDa

MISFQQKILNLIKCFRRQWPLFSNSERTTVCGADRMLTALQLSMAEVNKQHHGDFAVSPSDVMETWKYLLHDKLGLSYENMEEPENYAAFKEAYHTFLASSNMLDIIDIYQKCCALALLSEDERIAPIQLLEFISGAMNVSESNGSVLPSTPVNRQDQSSVKVMLFAKNCFYSYLSLLVNSKDDLALACILNVPDRGLGREAFTKLKHASRERKMSIFLMATSFIRTVEHGGKGCAASLFDPLRVHVKELSNFINFIDKLGEIVGEIPDPRVAGGQILSTVKMHLMKGQSNGDPFYQAVEKVVQDLDLKIKNIIDSQHEVLTASTTGVSPTRPKLHSINHGTAYCGRDTIKVLLVLLDEEAVSAPTQNKAELLYDDVNLNMFGITSVLTLFRSPAQSKESSPKPSRQRIQKPVNEKIIKMKRSSIKSQFACTYKNELSKIRSQHFLSSSQVPACMHPAPKQHLQGKYFTEGMNSCLDIPVLGTISENVHQNRNYREMGKLSCQPRNKNSKNEQMDLNNDNVIHDEESETSLPKNAKKLKTSNNPQKELDSKIGGKRKNNRTASKNKLIVGQAKLTQFFKL

PARPBP

PCNA-interacting partner

579 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.

Belongs to the PARI family.

65.054 kDa

MAVFNQKSVSDMIKEFRKNWRALCNSERTTLCGADSMLLALQLSMAENNKQHSGEFTVSLSDVLLTWKYLLHEKLNLPVENMDVTDHYEDVRKIYDDFLKNSNMLDLIDVYQKCRALTSNCENYNTVSPSQLLDFLSGKQYAVGDETDLSIPTSPTSKYNRDNEKVQLLARKIIFSYLNLLVNSKNDLAVAYILNIPDRGLGREAFTDLKHAAREKQMSIFLVATSFIRTIELGGKGYAPPPSDPLRTHVKGLSNFINFIDKLDEILGEIPNPSIAGGQILSVIKMQLIKGQNSRDPFCKAIEEVAQDLDLRIKNIINSQEGVVALSTTDISPARPKSHAINHGTAYCGRDTVKALLVLLDEEAANAPTKNKAELLYDEENTIHHHGTSILTLFRSPTQVNNSIKPLRERICVSMQEKKIKMKQTLIRSQFACTYKDDYMISKDNWNNVNLASKPLCVLYMENDLSEGVNPSVGRSTIGTSFGNVHLDRSKNEKVSRKSTSQTGNKSSKRKQVDLDGENILCDNRNEPPQHKNAKIPKKSNDSQNRLYGKLAKVAKSNKCTAKDKLISGQAKLTQFFRL

Parpbp

PCNA-interacting partner

573 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity).

Belongs to the PARI family.

64.105 kDa

MAVLNQLPVLGMIKEFRRSWRALCSSERTTLCGPDSMLLALQLSMAENNKQHRGEFTVCLSDVLLTWKYFLHEKLNLPIENMKVVEHYEDIKKTYDDFLKNSNTLDLIDVYKKCSSLTSNYENNMISPIQLRDFLSGTEYAVSDEANPHMPESPVKCSQNDEQVRVLVKKIFFSYLSLLVNSKNDLALASILNIPDRGLGREAFTNLKHAAREKQLSMFLMATSFIRTLELGGKGYAPSPSDPLWAHVKGLSEFINFIDKLDEILGKIPNPSLAGSRILSAIKMQLIKGHSSGEPFYKAVEEVVQDLNLRIKNIINSQEGVAVSANNISPVPPKSFAINHDTAYCGRDAVKILLVLLDEDAASAPTRNKAELLYNDESTVPHSGPSVLTLFRSPTQEKNTSVKPLRERIHKSLQTEKNKMWQTLIRSQFACTYKDDCIMSKNKWHVNSSSKPLSALHLEDDVSEGAQSSVGKARIEASSENAHVGRWKGDKLPRKSTQRQISKGKQLDLDSENLHCDRGNELYQHKNIKIPKVPSGSHSKAGGKLAQGTKGNRCPARGKLIPGQTKLTQFFML

Parpbp

PCNA-interacting partner

573 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). Binds single-strand DNA and poly(A) homopolymers.

Belongs to the PARI family.

63.902 kDa

MAVLNQMSVLDMIKAFRRNWRAHCNSERTTLCGPDSMLLALQLSMAENNKQHHGEFTVCLSDVLLTWKYFLHEKLNLPIENMKVVDHYEDIRKTYDDFLKNSNTLDLIDVYKKCSIMTSNCEKHMISSIQLRDFLSGTECAVNDENNPHSPASPVKCSQNDKQVRLLAKKIFLSYLSLLVNSKNDLALAQILNTPDRGLGREAFTNLKHAAREKQLSMFLMATSFIRTLELGGKGYAPPPSDPLWAHVKGLSAFVNFIDKLNEILGEVPNPSLAGGRILSAIRTQLIKGHSSGEPFYKAVEEVVQDLNLRIKNIINSQEGVTVSATNISPVPPKSFAINHDTAYCGRDAVKILLVLLDEDAASAPTRNKAELLYNDQSTAPHGGASVLTLFRSPTQVKSTPVKPLRERIHTSLQAEKNKQMRQTLIRSQFACTYKDDCIMSKSKWNVNSSSKPLSALRLENDVSEGAQPSVGKARLETSSENVHVDRSKDDKGPRKSTKRKLAKSKQPGVREDIHCDQGDELYQPKNVKILKVPSDSHRKAGGKLAPGARGNRCTTKDKLIPGQTKLTRFFML

parpbp

PCNA-interacting partner

573 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability.

Belongs to the PARI family.

63.961 kDa

MDCPLENVLDLIKYFRKEWPVVSDSERTTIYGADNMLLTLQLALAEVNKQNGKEFSASLSDVLLTWKCLVKHKLGLAYEDTAVPENYADIRKTYELFLKTSNSLDLIDIYEKISTLGSSEPHNFTSEQLLEFLTEDECFSGDKDFPVVSTPCKNNFDVVKVKATLKRIFLAYLNLLVNSKNDFALAQVLNCPERGLGREAFTDLKHTSRMKNMSLFLVATSFIRTIELGGKGYAPSESDPLRKHLKGLSLFVHFVDRLNEVLGETNDPRTAGELLLSTIKMHLIKGRSSGDPLSEAATDVAQDLDLRIKNLINLLSEDKYSVTPGISPARPKIHAINRGTASGGREMIKTLLKLLDEEAANPPSKNKADLLCADEENTLFGAVSLFTLFRSPEQKNGSSPKPLSHRVQKAMDKNKPKLKQNLIRSQFACTYKDGNLAQIKQWDFPSLSQVPTCIHPAPRIAPVLCFDEEPLENSDLQKQELKLSSGNIDLKTGGQVKNKPCKNVANKRSKRKQVDIQSETTNAQENEPPQKKAVVEITSKKENKPCVTRNCNKSSSKNKLIAGQAKLTSFFRV

parpbp

PCNA-interacting partner

568 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability.

Belongs to the PARI family.

62.469 kDa

MARVFRRECHRVLDSERTTIQGADGMLMVPQLAIAGVNKQERGDFGVALSEVLAVWKYFLLDKLQLSHKDIPLPQSYDLIRKEYDCFLKRTNTVDLIDVFSMFKELRLNEDPEEPLTTMQMFQFLFGENESSEKPSQPVCPATPSCKAADCSPQIQRVVRRVFCSYLDLLVNSKNDLALTYTLDNPNRSLGHTAFTDLRHAACDSASSLFLTVTSFVRAIQLGGKGYAPPESHPLRKHVKGLSEFLNFVDQCQDILGETPNPREAGCKLVSSIRAALVKGRSAGDPVYLAAEESTKSLKERIGQIHAMHTQSTVGTGISPARPKAYAINHATAYGGRETVKVLMALLDEEALALPCRNKAELLSEDHAALNGSTGACLLALYKSPEAPTGSSPKSLRNRVLSQQEHIKSKVVRPTIRSQFACTYKEEELPLNRVLEFPSTSQIPTCVHPAPKKASSESDNGMDNRFKEATNLRCEGPGQSALGEHSGNAWNQTGGKSTQPEPLRRATGTLKRKLANRECTEQGREENQPPQKRPPAKAATGGPGKRNNKAVSKKLIAGQGKLTGFFRL

parpbp

PCNA-interacting partner

567 amino acids

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability.

Belongs to the PARI family.

63.048 kDa

MDCPHQDVLHLIKYFRKEWPVVSDSERTTICGADNMLLTLQLALAEVNKQNGKEFSVSLSDVLLTWKYLVKHKLGLACEDTVVPKDYADIQKTYDLFLKNSNSLDLIDIYEKISTAGSSEAHFLSSEQLLDFLTNDVCLSEGTDFPIVSTPCKNNLDTVKVKPTLKRIFLAYLNLLVNAKNDFALAQVLNCPERGLGREAFTDLKHTSRLKNMSIFLVATSFIRTIELGGKGYAPSESDPLRKHLKGLSLFVHFIDRLNEIFGETHDPRTAGELLLSTIKMHLIKGRGSGDPLSEAATEVAQDLDLRIKYLINLVSEDKSSGTTGISPVRPKIRAINRGTASGGRETIKTLLKLLDEEAANPPSKNKADLLCADEENTLFGAFSLFTLFRSPEQTGSSPKALSQRVQKAINKDKPKLKHNLIRSQFACTYKDSNLTQTKQWDFPSMSQVPSCIHPAPKIVPVLCFDEEPLENDLQKGLKQSSGNIDLKTAEQVKNKPCKNVGNKRSKRKQVDIQSETTNGQENEPPQKKAVVELTSSKANKQGVSRNKASKNKLITGQAKLTSFFRV