Protein
Poly [ADP-ribose] polymerase 2-A
Organism
Oryza sativa subsp. japonica
Function
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).
Sequence
MSARLRVEELRAELQRRGLDASGNKPVLVRRLDAAIRKEEEEEAAVSAAAKEEADAGGVVDGEGNGEDKRKRKRRGDGEDVDNSESDAAKLEGMSYRELQALAKSRGLAANGSKKEVIERLLCAPSDTDGGVQDKKKIAKGFADGDDRVEECRKEKIVTATRKGAAVLDQHIPDHIKMTYHVLQVWFLLKGDEIYDATMNQTNVGDNNNKFYIIQALESDAGGSFMVYNRWGRVGARGQDKLHGPFSSREQAIYEFEGKFHGKTNNHWSDRKSFECYARKYTWLEMDYGEADRETNKKVSPSTDQIKETKLETRIASFISLICNISMMKQQMVEIGYNSDKLPLGKLSKSTIFKGYDVLKRISNVISRADRRQLEQLTGEFYTVIPHDFGFKKMREFIIDTPQKLKAKLEMVEALGEIEIATKLLEDDSTDQDDPLYARYKQLSCDFTPLEVGSEEYSMIKTYLANTHGKTHTSYTVDVVQIFKVSRHGEMERFQKFATAGNRMLLWHGSRLTNWAGILSQGLRIAPPEAPVTGYMFGKGVYFADMFSKSANYCYASEACRSGVLLLCEVALGEMNELLNADYDANNLPKGKLSTKGVGQTEPNTAESKITDDGVVVPLGKPKAEPSKRGSLLYNEFIVYNVDQIRMRYVLHVSFNFKKR