PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

887 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.

Belongs to the protein kinase superfamily. PAN3 family.

95.613 kDa

MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLALAGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIPGMDGGALTDTSLTDSYFSTSFIGVNGFGSPVETKYPLMQRMTNSSSSPSLLNDSAKPYSAHDPLTSPASSLFNDFGALNISQRRKPRKYRLGMLEERLVPMGSKARKAKNPIGCLADRCKSGVPINMVWWNRVTENNLQTPNPTASEFIPKGGSTSRLSNVSQSNMSAFSQVFSHPSMGSPATAGLAPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDPNADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAANGQL

Pan3

PAN2-PAN3 deadenylation complex subunit Pan3

837 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.

Belongs to the protein kinase superfamily. PAN3 family.

89.745 kDa

MNSGGGGGLPPPSAAASPSSSSLAAAVAVAVAASSGVGGVPGGPAAAAGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLALAAAAGAAFPPGALPGGGAGPPAGPKKPELGVPGAATAGGGLDGPRVAIPGMDGGALTDASLTESYFSTSFIGVNGFGSPVETKYPLMQRMTSSSSSPSLLNDSAKPYTGHDLLTSSASSLFNDFGALNISQRRKTPNPTASEFIPKGGSTSRLSNVSQSNMSAFSQVFSHPSMGSPATAGLAPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASFMVPPSASTPANNPAPQPPSSGQVIQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDPNSDAYFTKRKWGQHDGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITSKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAANGNDRNSN

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

794 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

88.082 kDa

MNINLDSAKDVLCKNILIYGYCKFQDKGCAFSHNKQLTTPQQQQQQQQIEEEEESIRQGGTAVGVPGSQRNKGAGAGTGAKAIQSNGMVNSQETQSKRRFDANSPLFQPAVNNAKGTAVTNLASKFSNLSPRIRDAPVFKPENESPISQELNSKLATSGLGSIYSSKKFNASTPSFTPTGFDFSVAAQVGNNPGSTAPANLQLQQKQPQQPQQPQQPQQHQQQQQLGLQNLNQTQLGRNLNVLLQPQISQPFIPANAIPPSSAAGQLQLHMQVQQPQAQTQPPSHLTPSSIMSSAPMSAGFYTSALPIPQGGGMRNQPPSASMYPLQYHLYAPAPPPRLAVPTKEYETDSQQLFLPNELRESLHRKNEASLQTMQHLSLPDHVNSYHSLVPIDKSYDSSSKIWPGKSTVLFKCNSNFDGNLYALRKIEPCNEIVDETPFRNIRKWKSLHNNANIVALRDAFTTMAFSNTFSSPNSSAGNEVVGANGASLCFVYDYYPNLTTLLERHKKGIRVVPITEDLLWSYLTQLVNAVAAIHAKKLALRSTIDLSKIINTTEDRIKLSGCGISEVLSFSASNANASSGEEDEEREFARLRALDIVDLGKVLLELSALLLPMNLRASLTSTLLKNLANSTKLSQNFLDVLQVLTDPSLLQEPYSFDMDQFILQYISSHFMTLMNKLQNSHDWVELQLSTELENARLFRLMTKINFIISEMPTYDLNSQNRLKIIKVFQENLFNSVGPNGKKVVNMDRVLVNLNKLDCGIDEKTLLISDKECMIITFKEIKELIDTQFRLLRG

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

790 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.

Belongs to the protein kinase superfamily. PAN3 family.

85.391 kDa

MCSTYGLLSFEFSDTAAMDPIFFSPTNGIPSESKLATYMNRQNVATPSGYGLNNGFSLLNLDSPLNKKSQVTPQSPEFIPTRLGSTPNFYAPYHNAPMQLSNGLNGVNGLTAAAAAAAAAAAAAAAAVPSSTSSASSASVTISKTANGGASMLALQKTASIASVTIAQQQPQHPQKQQQHPPSVGGGAVSAASAPIAISGAPPNPAAAPFVSSMSAQTPLKGRGAMMRQESPTAAMISGAGPGEKSPPHGMTPHGASPIPSALPTSVHQENVGGTIYFYPTANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPKTLLESAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLEPPAQPLHAKLTFPATTYRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISDITQFDPNASNPLALVNMHQQDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNRRSVTDLMPMIGARFYTQLDALQSKIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLFHSVTEDGRPWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSSAAN

pan3

PAN2-PAN3 deadenylation complex subunit pan3

787 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.

Belongs to the protein kinase superfamily. PAN3 family.

85.905 kDa

MNSGLTPSPSPAVAAAGPAGVPGSKLKFCRYYAKDRTCFYGDECQFLHDDQLGGIHGNGNSPLSLPGGGPAAVYPQPVTPVGSKKLDLAGLEAQRLAIPGLDGGAIPDTSLTDSYFSTSFIGLNGFGSPGEATYPRMQQRMTNSSSSPSLLNDSAKPYAAHDPLGSPASAMFNDFGGLTMSQRRKTPNPTASEFIPKGGSTSRLSNMSQSSMSAFSQALFSHPSMGGPTGAGLAPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPANYMVPTSASTPVTNSVSQPPSTGEIIQKATVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHIAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPGVPAEVDSYHSLFPLEPLPPPNRIKTSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMSLVDTWKKIQHSNIVTLREMFTTKAFGEHSLVFAYDFHAGSETMMSRHFNDPSADAYFTKRKWGQHDGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGIFDVLTYDGSQNNPVALMPQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTEQNRMRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPAWSETGDRYLLKLFRDHLFHQVTEAGTPWIDLSHIVSCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELVAAANGQL

pan3

PAN2-PAN3 deadenylation complex subunit pan3

746 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP.

Belongs to the protein kinase superfamily. PAN3 family.

86.441 kDa

MMYQQQPKNQKQCKNIALHGYCRNSDKCEFSHELTPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNSNGNGSNNTATSNNPIISPNSNIASPLKKSPIDNLTTSFQNLSTNQQTNHHWADHFQSGIPEYIPKQQLQQLQQQQLLQQQQQQALLLQQQQQQNYDDDQHLYPYGDNSVDDYEQHQYEPQPQPNNGIDPNMNNQFQINNFVAAQMRNASPQSYQQQFQQPNPSPQSSSQQQQQQQQQQQQAVYQQQQQQQPSSQPLAQNPSLQNNNNKLLQLQLQQHLQQIQAAQQQAQINQSYTPYPSYSQSVIRNKPGRRNIGSFFMSESLKQDILNQKSLLYLTLDPNDPRIKNIPPMLNKYHSLYPLDHDASRENQGKMFGYITSVYKAISTLDGLPYAIRRVEGFRLSSEYALQAAETWRNIQHPNIVSLKEIFVSKEFGDNSSLFFTYEFFPGSETLESKYLSQSGNPLSESVLWSFICQITSALKTIHSAGLVCRVIHPSKILLTGKNRIRMNGVGIFDVVNFDTPRILAQYQHEDLLLFGRLILTLACRSAQSTTTTNLSKSIEYVSNQYSKELYNLIVYLLTKPVINLPNIDEVVLMISGRLLQENNYLHTYTDDLETELSKEYENGRLFRLVTKLGFINERPLYDMDPRWSETGDRYLIKLFRDYIFHQVYDDGTPVLDFYHVVETLNKLDCGVDEKILLMSRDEQSLLVVSYKDLKKCIDSAFSELVSQKSHI

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

717 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

79.802 kDa

MDKINPDWARDVPCRNVIIYGFCKKKTEGCPFKHDDDDIATPTSTPKVADTVPAPSGVIQQPSKISVSSLPSLNSQPSSTAPTSAPNATAHTGSKSQVPKFNAKASASFTPMSKAADGTQETQAPYLESPVAGSPGPILKAGTPVSFMQPNIYSTTPVPSPASMAMPNVVMPPNDMGSPDLGLQQQSHMVNLDGSIQQNYQERPNVLMRDSSMPLTMGTSGSRPMLDQQIHSISGLSNTSGPQPPGLLQSMNGASMDMGLPMNLRYPTIYPPTHSILQYHLYAPDPPPQLEIALKENERTPRMLFIPNDLREELVKRNLASLQLFPSGGNLPHIVKDYFGLVPLDFHQRSSVKDRYKKHKNSLYKVFSNVDGRIYLLRRIHDVNISDPTIISKTFQKWSKIDSSNVVALKDLFLTTAFGDSSLGIVYDYYPNATSLYEAHFVNYPTVEVTEDLLWSYAVQILNGLREIHNTNGVNIGDLDCDKIILTGKGRIKISAGAEYDIMNMCCPEDNEDDDNEEKLRKRNFVDLGEILFKLASKMCNCHGKDVANLAQVSEKLKNLIKSLAFEQLHDYVNVATIIEKYIGLDVVFKVMEAQQTYSEYAENVLSRELENGRLFRLICKLNFIFGRVENRLDINWSEPGDKFVIVLFYDYVFHQIDPNTGKPVTDLTHVLRCLNKLDAGVEENILLVTPDELNTAVVSYKKVKELVDKTFRAMTL

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

697 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

77.933 kDa

MNINLDTAKDTLCKNILIYGYCKYENKGCAFSHNRQQPAQQQQATNTSNNSTSVITPNSANSTASSADLSSKKKFNLNTPSFQPSVSNLSNKFSTLSPKLKEIPVFKPENGVSEPDTVDSPTTQRPFTSKRFNVSTPSFTPTNFDFANNSNADGNRGGASTPIGISSAPLVQNQQQQQQQQQQQQKQPLAVPSPLASGAQPPTMQHRILSMGVSQSSPSTNPYFANNLDMSAPTPGSETPGPVLPGSAGAAAAAANQPMYPLQYHLYAPAPPPRLTIPLQPYETNSQAMFIPNDLREYLHKKNEASLQSLSHSNLPEHVNQYHSLVPIDKSYEPVSKLWLGKNSLIFKCLDNIDGNLYVMRKIEPCNEIINEKPFKTIKRWKSIKNANIVGLQDAFTTMAFNGNQSGNTSLCIIYDYYPNSISLLEHHKKGLRVEPVNEALLWNYLIQLINAIMAIHEKGLSASSTIDLSKIIVTNKNRIKLSSVGISDILEFKDDETNQDIKIRQLQDIQKVGKVLMELAILLLPVNMRQSNNIYNSLKASTNLSEEIINNLQELNDLDTASGEFDLNEFSQRLTPKMFNIIDSLQNSSDFIEGQLTSELENARLFRLMTKLNYLIHDNSNSENDKIIKLFLNYVYNCYDSNNKKVINLNKVLINLNKLDCGIDEKILLVNNDECIIISYKELKEIIDTKFRLMRE

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

684 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

75.082 kDa

MLPPPKSAAVQIVRPPSPSSEKAKEKEKKHSPEKRETAQRICRNVMIYGYCKYQDQGCIYYHPPAGADPSTPQNSSPVAHAPTPSAPTPLAGTPAREKPTLSIEHLAAPVFVPKGLDSSPRASTPSVPTPSAPTPPVWPSLPSTGLLPRQDVQVSAQPSHAQLSATASPMAYDDPSHIALSAAHAHAQAQALTHGILDPHAHAPPVDQSMYLPPRQPLDYNLYAAPLPSIGGNPLYPTHPHAFFVSDDLRRAIQAKQEAVYAGANGASAPGLPQELGVYHSLIPLPLPAPTAQCPPTQSQPSKVYGLPSPVYRATSEVDGNTYCLRRVEGFKLVNQLAFASMDTWRRMRHPNIVGLKEAFTTKTFGDNSLIMVYDYHPLSTTLYDEYLSPNPPEPSPASALANQPPKRRSSPPERILWSYVTQIANALKAIHSSGLAVRNLDASKILLTGKNRIRLNGCGVWDVLAFDNKTPVQAFQQEDLLSFGKLIISLTCDFFQPTLPFSLPLEHISRHYSSDLSNLILYLISKPAQGQIKSIDEVVKMMGPRILNELDAVQSYADVLENELGAEVENGRIVRLLTKLGFINERAEFELDPRWSDTGDRYILKLFRDYVFHSVGVDGKPILDLSHVLVCLNKLDAGLDERVMLVSRDDQSCLVVSYREIKHCIEAAFNELKNAGNNHRVHR

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

684 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

75.082 kDa

MLPPPKSAAVQIVRPPSPSSEKAKEKEKKHSPEKRETAQRICRNVMIYGYCKYQDQGCIYYHPPAGADPSTPQNSSPVAHAPTPSAPTPLAGTPAREKPTLSIEHLAAPVFVPKGLDSSPRASTPSVPTPSAPTPPVWPSLPSTGLLPRQDVQVSAQPSHAQLSATASPMAYDDPSHIALSAAHAHAQAQALTHGILDPHAHAPPVDQSMYLPPRQPLDYNLYAAPLPSIGGNPLYPTHPHAFFVSDDLRRAIQAKQEAVYAGANGASAPGLPQELGVYHSLIPLPLPAPTAQCPPTQSQPSKVYGLPSPVYRATSEVDGNTYCLRRVEGFKLVNQLAFASMDTWRRMRHPNIVGLKEAFTTKTFGDNSLIMVYDYHPLSTTLYDEYLSPNPPEPSPASALANQPPKRRSSPPERILWSYVTQIANALKAIHSSGLAVRNLDASKILLTGKNRIRLNGCGVWDVLAFDNKTPVQAFQQEDLLSFGKLIISLTCDFFQPTLPFSLPLEHISRHYSSDLSNLILYLISKPAQGQIKSIDEVVKMMGPRILNELDAVQSYADVLENELGAEVENGRIVRLLTKLGFINERAEFELDPRWSDTGDRYILKLFRDYVFHSVGVDGKPILDLSHVLVCLNKLDAGLDERVMLVSRDDQSCLVVSYREIKHCIEAAFNELKNAGNNHRVHR

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

680 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

75.267 kDa

MATTRYNSNDFRRQLGSPRPKGRADTKDTLCRNILIYGHCRYEDAGCAFNHDQTKKSPKPDATTRKTLNVDSAPFTPAVSSQPSKKTFSSSHAASAAVFTPRATAATPTGTPTAQETDIPPAANTPSAFSNIAAIREFTPQQQNYDLTTNGAAAATQDASLNYDPFTMSSVASALPAAQYNPYASTDHTGLVAHGGAYFPSAQAGYQSLIPPSFHLYAPIGPYREDLQPWQRSTYDFFMPENLRLELQNKSHAALQTMTGTAALQMPQVGNYHTLVTLDKTSNRKSSSLFGYVTWVYKAVSGKTSRLYSLRRLEGFTVSNDQILRPVKEWKKITNGNIVAMQDAFTTRAWGDSSLMFSFEYYPLAETLMEHHFPNAQHKTSFRSNTNHQASETVLWSYIVQISNALNSIHSNGLAARCIDATKIIITGKNHIRLSSCGILDVINYEKSKPMTELQEEDFVAFGKLIVSLATNTPPTGLNLGKAIEQMGRNHSSTLKDMVLWLLNPPQASGQKTVKNLVAGINEHVMTAFDAQQRQSDMLYSELYREVENGRVLRLLMKLATINERTEYDKDAGWSENGDRYMLKLFRDYVFHQVDAQGRPVLDPGHMLRCLSKLDVGTEERIKLTSRDCETDFLVTYKDLKGAVQSAFGELLKGSGNGRGGPVASGSGHGVHHPSHRDRF

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

679 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.

Belongs to the protein kinase superfamily. PAN3 family.

76.455 kDa

MDKINPDWAKDIPCRNITIYGYCKKEKEGCPFKHSDNTTATTINDVPPPIDVGEATTPTMTSVPKFNAKVSASFTPMTVGSDSLTTVTNTTSAATNATGNIAMAATSATASTVNPMINPIVNSSLVNNNNNNSNISISIPTTASSSNYDPFNAPIFTPSSTSSIHTNANAHSFPFPSIANSGGININATDDNSNNMSMANNVPPPMQPPPIESSNLKYPRIYPPPHSLLQYHLYAPEQPSSLKSLLKPNERSADQLFIPNNIREDLTKKNLSILQVFPSSGKVIPSIVQDYFNLVPLNFNNNDFLNKTTLFKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNWRKVLITGDPGRIKLSHCNFMDLLFNDDTDTVVSSGGSTIEGQQQLDYKYLGELLFNLSINIENSNNNTAPKEYRLEEITPQSIDDMRQIDDKFKDVLKYLISDNGDSKKSIHDLTSHFYDKMFMVLESSQTYTEYMESVLSRELENGRLFRLVNKLNCIFGRIESRIDINWSESGTKFPIILFYDYVFHQVDSNGKPIMDLTHVLRCLNKLDAGIQEKLMLVTPDELNCIIISYKELKDLIESTFRSITQ

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

670 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

73.91 kDa

MQVCVNFIQRRATELQPKVILINRLSAHLSTSPSPPLPHPLVTTSHTPVGALTPKPPNTSFGSHHQVSIAMPKFNINSPSFTPSVVDKAAIDSTGPAAPAAAPAFVPGKSPIDLEQIKNKLTISKDKKENAKSALPKLNPAVAGFTPGASASGSTTPKMATAPSFQPNQTSAINTNSNSSASATSQSGPPGASFQPNQSFQPGAASFQPRFQSGPSQIEPGYDNYYDEMSNGAVMAAAQNQQFPLQYHLYAPHYLSASRQRQLLSHQKTAKDFFLDPHLHQRLHKQSEDLLRVEGSSNLPRFVDKYHSLVLLDSNLNTKENGAPGESPQWVYKCMNGKDGKQYALRRIQGFVLTNEQAMTSVRKWQSIVHPAFVSLCEAFTTRDFGDASLCMIYDFLPSAETLFDLLNRGQQFSRDVIISYLLQLLSVLDTIHSAGLAAKTVDPTKILVCGPGRVRLNCCGLYDVINFDKDENVTLFQQQDLRNLGLLVLCLACNSVEATKNVEQSLTRLDSELQEIVQYLLSSNTSKTASRVLASLTPLLTATFNESLNTNDSLEHELRRELENGRLVRLMAKLNFITERPGPDPEMSQQWSETGDRYLIKLFRDYVFHQQDEMGKPVMDLGHVVRTLNKLDAGIDERITLISRNGQNCLIVSFKDLKQCIESALRDLE

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

669 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

73.827 kDa

MATTFGSPSGDSRRGVASPRPKGREAKNTFCRNVTIYGHCRYENSKCRPPHLPDHVLNQNENAKKRFNVDSPSFTPLTTTPNGSVTASARNAAISPKAANAAVFTPKSQRSAVSTPNLHNKEPALDWHAPDFQEFVPETFGGPMVDSNASASYSGYDPYTSSANLASIAGQGHQSSAMNPYAQGHSGLEASYYQNPSAFQTSPAYHLYWPVGPQPTSLLGYQRTAHDFFIPDALREDLQKRAEVARQVMPNSTLPVIEQFHSLFCLDTTPQKNNAPFGYVSWIYKAISGKDGKTYALRRLENFRLTSEPAIRSAQAWKRIFNGSIVTIHEAFTTRAFGDSSLIIVTDYHPNSKSLADEHFKPMQRFNGRQATSSHVPEHVLWGYIVQIASALKAIHGSGLAARLISPSKTLLTAKNRIRLNACAIMDIVQFETARPVAEAQADDFVQLGRMILCIANNNTTAHLQMQKSMDHVTRNYTARLKECIQWLLNPQPPLGTPSSPTTPAPGSKDIDNFLGGISDQLASVFDSELHAQDTLTNTLGRELESSRIVRLLVKLNMVNERPELDASQQMSGGNTSNPSSVWAETGERYYLKLFRDYVFHQVDANGHPVTDLAHVLDCLNKLDAGTDEKIALISRDEQNVLIVSFREVKRGLEIAFQDLIRAGRGQGK

pan3

PAN2-PAN3 deadenylation complex subunit PAN3

664 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

73.781 kDa

MATTGKSATLEDARHGTGSPKMKGRENAKDTLCRNVTIYGRCRYEDKGCAFNHDPHKVNSGYQSDSNKKRLNVDSPSFTPSILSSNGSSPTSQSATMKKMATISPKAASAAPFQPRSISSRSNSSTPTTRPGTMTPDWSVAEVQEFVPQGFDTAHIGSLQGNGTAGVPSTSAFDPFVTAPNPLSAANAVGPVQANPFSHDTAAALNGAAFFANQSGFQQPVQYHMYAPIGPHSQNTLGYQRNVHDLFLPNDLREEMQKKAAATLQTLPNTQLPAQVDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGNRFQGRHNTHIPEQVLWGYMTQIANALKAIHASQLAARIIDPSKILLTGRNRIRLNACAIMDVVQFDTQRSLAELQRQDLVNFGQLIVTLGANQPNVMHNPTKAMEHFTRAYTAQLKNSVFWLLNGLQKDQERNIDIFITGISSTLMSTFDSALHLDDQLTSDLSRELENGRLVRLMTKLNFVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAQGDPVVDLGHVLMCLNKLDAGTDEKITLISRDEQSCFVVSYKELKKALESSFQALLKPSASRRLH

pan3

PAN2-PAN3 deadenylation complex subunit PAN3

662 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

73.52 kDa

MASAGKPALDDSRRGTGSPKIKGRENAKDTLCRNITIYGRCRYEDKGCAFNHDPHKVNSSNQSDSKKRFNVDSPSFTPSLLSSNGSSPTSTPATTKKMTTISPKAANAAPFQPRSVVSRSNASTPGLRQDTVTPDWTVAEVQEFVPQGFDNSHLAALQGNGNGPITSTSPFDPFVTTPTPLSAGGAVGPVQPNPYSHDAAAALGGAAFFPGAAGFQQPVQYHLYAPIGPHNQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQIDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNYYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGQQRFQGRHNVQHIPEQILWGYMTQIANALKAIHSNGLAARVIDASKILLTGKNRIRLNACAIMDVVQFDSQRTVADLQRQDLVNFGQLIVTLGANSPTVMHNPTKAMEHFTRAYSPQLKNSVFWLLNGMQKDQDRNIDVFITGISSQLMSTFDSALHLDDQLTSDLSRELENGRLVRLMAKLNFVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAQGDPVVDLGHVITCLNKLDAGTEEKITLISRDEQSCFIVSYKELKKALESSFQALMKPARRMH

pan3

PAN2-PAN3 deadenylation complex subunit PAN3

662 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

73.379 kDa

MASAGKPTLDDSRRATGSPKMKARENAKDTLCRNVTIYGRCRYEDKGCAFNHDPHKVNTTYQSDSRRRLNVDSPSFTPSLLSSNGSSPTTASVTAKKAATISPKAANAAPFQPRNITSRSNTSTPSGRAETMTPDWSVAEVQEFVPQGFDTAHMASLQGNSNGGVPSTSPFDPFVTASNPLSAASAVGPVQANPFAHDTAAAAAALGGAFFAGQSGFQQPVQYHLYAPIGPHSQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQVDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGNRFQGRHNTHIPEQVLWGYMTQIANGLKAIHSNGLAARILDPSKVLVTGKNRIRLNACAIMDVVQYDTQRSIAELQRQDLVNFGQLIVTLGANTPSVMHNPTKAMEHFTRAYSPQLKNSVFWLLNGLQKDQDRNIDIFITGISSQLMSTFDSALHLDDELTSDLSRELENGRLVRLVTKLNFVNERPEYEHDRQWSENGERYFLKMFRDYVFHQVDAQGDPVVDLGHVLSCLNKLDAGTDEKITLVSRDEQSCFVVSYKDIKKALESSFQALLKPTRRLH

pan3

PAN2-PAN3 deadenylation complex subunit pan3

661 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

73.162 kDa

MASVGKPSLEDARRGTGSPKMKARENAKDTLCRNVTIYGRCRYEDKGCAFNHDPHKNSNQSDNASKKRFNVDSPSFTPSLLPSNGSSPTSSSSSLKKSSTISPKAANAAPFQPRTAASRSNTSTPGVRQDAVAPDWSVAEAQEFIPQGFDPTHMSPLHGNGNPGVASANAFDPFVSTPNPLAAPGAVGPVQANPFSHDAAAATLGGAYYANQAGFQQPVQYHLYAPIGPHNQNALAYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQVDYFHSLVPLDLNHQKNAAIFGYPSWVYKAQSTKDGSYYALRRLEGFRLTNEKAIRSVQAWKRIASGSMVTIHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLSAGGPRFQARHNAHVPEQILWGYITQIANALKCIHSAGLAARIIDPSKILLTGRNRIRLNACAIMDVVQYDAQRSVADLQRQDLVNFGQLILTLGANQPNVIHNPSKAMEHFTRAYSPQLKNTVMWLLGGMQKDQERNIDILINGISSQLMSTFDSALHLDDQLTSDLGRELENGRLVRLLTKLNFINERPEHEHDRQWSENGERFYLKIFRDYVFHQVDASGDPVVDLGHVLTCLNKLDAGTDERITLVSRDEQTCFVVSYKELKKGLESSFQALLRPSRRPH

pan3

PAN2-PAN3 deadenylation complex subunit PAN3

661 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

73.541 kDa

MASAGKPALDDSRRGTGSPKIKARENAKDTLCRNITIYGRCRYEDKGCAFNHDPHKVNSSYQSDSKKRFNVDSPSFTPSLLSSNGSSPTSTPATTKKMTTISPKAANAAPFQPRSVVSRSNASTPGLRQDTVTPDWTVAEVQEFVPQGFDNSHLATLQGNGNGPITSTSPFDPFVTTSTPLSAGGAVGPVQPNPYSHDTAAALGGAAFFPGAAGFQQPVQYHLYAPIGPHSQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQIDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGQQRFQGRQNVHIPEQILWGYMTQIANALKAIHSNGLAARVIDASKILLTGKNRIRLNACAIMDVVQFDSQRTVTDLQRQDLVNFGQLIVTLGANSPTVMHNPTKAMEHFTRAYSPQLKNSVFWLLNGMQKDQDRNIDIFITGISSQLMSTFDSALHLDDQLTSDLSRELENGRLVRLMTKLNFVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDVQGDPVVDLGHVISCLNKLDAGTEEKITLISRDEQSCFIVSYKELKKALESSFQALMKPARRMH

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

660 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

74.148 kDa

MNINLDSAKDTFCKNVLIYGYCKYENKGCAFSHTVKPTSSVPGSQGSNATTNSSGNTNADMKKKFNFNTPSFQPSTVPNLTNKFSNLSPNLKEIPVFVPSGGMSNADSGGMNEPEMNDSVTPNKKFNASTPSFMPSNPYISNNDQISAPSPVMAQSVSTPGAKANGNIQHNPYLPGNAGTPQPTSAVAAPNSADVFFQQPTSSYPLQHHLYAPAPPPRLTIPLPPHEINVNSMFIPNDLRETLLKRNEATLQTLPRSNLPDHVNIYHSLVPIDTSFENISKVYELPSFVYKVFSNVDGNPYALRKIDIQSVLRITNELPFKYIKKWKSVKCANIVQLQEAFTSMAFGGSYSSLIVTYDYFPNSNTLQEQHISRRLGGKLEPITEELLWNYVIEITNALINIHENNLAARSALHLSKILVTNKNRVRLGGVGISDILNYEDDEEQIQQKGLDAFRHELQQADIKKFGKLILDLAALCLPNNARNHEPKDLISLLKTSTTVNFSGEFINLLTELNMNTSDLQEFNRNHLSRRILNFCSNAQDSQDFMESQLSTELENARVFRLITKLNFIIDRPEYDNDPNWQENGNKYIIKLFRDYIFFQYDEFGKPVCDLSRVLTNLNKLDAGIDEKFLLVNKDEKNCIIVSYKEIRDIIDSAFRTLTRG

pan3

PAN2-PAN3 deadenylation complex subunit PAN3

659 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

73.403 kDa

MASAGKPALDDSRRGTGSPKMKARENAKDTLCRNVTIYGRCRYEDKGCAFNHDPLKVNSAYQFDSKKRFNVDSPSFTPSLLPSNGSSPTISSATMKKMATISPKAANAAPFQPRSVASRSNTSTPNSRQENINPDWTVAEVQEFVPQGFDVAHMTALQGNGNGTITPTNAFDPFVTASTPLSAGGAVGPVQPNPYSHDSAALGGAAFFPGSSGFQQPVQYHMYAPIGPHNQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQIDYFHSLVPLDLNHQKNATVFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTIHDAFTSRSFQDSSLIFVTDYYPLSKTLAEQHLGTGQRFQGRHNVHIPEQVLWGYMTQIANALKAIHSNGLAARIIDASKILLTGKNRIRLNACAIMDVVQYDSQRTVADLQRQDLVNFGQLIVTLGANSPTVMHNPTKAMEHFTRAYSPQMKNSVFWLLNGLQKDQDRNIDIFITGISSQLMSTFDSALHLDDQLTSDLSRELENGRLVRLMTKLNLVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAQGDAVVDLGHVLSCLNKLDAGSDEKITLVSRDEQSCFIVSYKELKKALESSFQALLKPARRMH

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

657 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

73.083 kDa

MASAGKPNIDDGRRGTSSPKLKGRDHAKDTLCRNVTIYGRCRYEDKGCVFNHDPSRVNDAQHPERSSSKKRFNVDSPSFTPSATPLNGSSGLKKSATISPKAANAAPFLPKGVLSRSNAATPQSQPETSTPEWSIGEIQDFVPQGFDTSHVESIHGHGNGVLSTPAYDPFVSSSTPLGASGAVTHQVQPNPYSHDPSAIGGAAFFGAHNAFQQPVQYHLYAPIGPHNQNILGYQRNIHDLFLPNSFREELQKKAAATLQTLPNSQLPTQIDYFHSLVPLDLSHQKNAAIFGYPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQNWKRVSCGSVVTVHDAFTNRSFQDSSLIFVTDYHPLSKTLAEQHLADGQGRYQGRHTSGHIPEQILWSYVTQIANALKAIHSAGLAARVIEPSKILLTGKNRIRLNACGILDVVQFDSQRPLADLQHQDLVNFGQLILTLGANSPSLMHNPTKATEHFNRSYSAQLNNSVYWLLSGMQKDQERTIDIFISGISSQLMSTFDSSLHLDDQLISDLSRELENARLVRLLTKLNFINERPEYEHDRQWSENGERYFLKLFRDYVFHQVDAQNAPVVDLGHVLTCLNKLDAGTDEKVTLISRDEQSCFIVSYKELKKAVEASFQALLKPARRI

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

656 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

73.34 kDa

MISSASGTNWNRPDSFKGTQCRNIIIHGYCKFENEGCQFNHGNSKETEGQTTDEVPTQRSMTPLNVKFNAKTSSSFTPGKSPAVRSPDFSSLPAFQPGAPVNDQPMLADGPQISGTMSPSLMNSNATAFAPSFNPYASESFTPSVSAGGIPSSQELAGTLHGSNPSIPSPVPSNPYVNSAGLPSGGMLGVGHPMQGLPPPPPPGALPVNPITQFPTVYPPTHSVLQYHLYAPDPPPHLKIPLKPNERTPETLFINNHLRDRLVKNNQTALQVFPRGSLPDIVGDYFGLVPMDFHNRTSDKKRYNGHKNSLYKVFSNLDGKIYFMRRIHDVKITDSAQVSKPFQTWSHLRSANITVLKDSFVTSAFNDSSLCMVFDYYPQSQSLYETYGLANSVNELNQEYLWAFLVQLTIALQEVHSNGLALNDLDWKKVIVTGEPGRIKVTDIGVYDTLNYHQEGRMLHTEQQQNYLSLAELLLNLVQRLCGASGPLDDVKSYHIDPLFKKCIQYLQDTSNNNKNIEDFTKLFSHKVLSVVNSLQYNSEYLEQQLSRELENARLFRLMCKLNAIYGRLESRIDINWAESGEKFPIILFFDYVFHQKDDTGKNVMDLTHVLRCLNKLDAGVSERLMLVTPDEMNCIIISYKELKDLIDSTFRALTQ

pan3

PAN2-PAN3 deadenylation complex subunit PAN3

653 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

72.44 kDa

MASDSRRGTGSPKMKGRENAKDTLCRNVTIYGRCRYEDKGCVYNHDPNKTNSAYQSDSKRRLNVDSPSFTPSLLSSNGSSPTSSSATLKKTTTISPKAANAAPFQPRGISSRSNASTPSARAESAAPDWSVAEVQEFVPQGFETSHMASLQGNGNGPVPSTSPFDPFVTTSNPLAAANAVGPVQANPFSPDTAAAALGGATFFTGQTGFQPVQYHLYAPIGPHSQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQVDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLSAGNRFQGRSNTHIPEQVLWGYMTQIANALKAIHSNGLAAKIIDPSKILLTGRNRIRLNACAIMDVVQFDTQRSIADLQHQDLVSFGQLIVTLGANSPSVMHNPTKAMEHFTRAYSPQMKNSVFWLLNSMQKDQDHTIDIFITGISSQLMSTFDSALHMDDQLTSDLSRELENGRLVRLMTKLNFINERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAHGDPVVDLGHVLACLNKLDAGSDEKITLVSRDEQSCFIVSYKEIKKALESSFQALLKPTRRVH

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

648 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

72.56 kDa

MAATRYPPNDLRRQVGSPRSKGRENKDTLCRNILIYGNCRYEDQGCTFNHDQNKNPSPQADFSKKTFNVDSPAFTPSSQPQVLAKKTTLSSQAANAAPFTPRGAGTPNLQQTAEASVFNPAAIREFTPQNYDIGNTNSNGVPQENGIYSDPFTTMGSLGSTLPSAGQYNLYASDHNSLGGPGAQFYPQHGSFPAGPLQPPNYHLYQPHDSYRQELQPWQRATYDFFIPAKMREELQKKMFATQQVMPNSGLPQLERWHSLFPLDTNNRKNTSSFGYPSWVYKAQNSRTARHYALRRLEGYRLTNEKAILTVMKEWKKIKNGNVVTVHEAFTTREFGDSSLIFAYDYHPLSKTLQEHHLQPTHGNRYRAPSAVPENVLWGYICQITNALKTIHSNKLAARCLEPSKIILSDNNRIRLSACSILDVVQFESNTKSVAELQQEDLVKFGKLILALATGAPPAHLNNIQVALDSLVTKYSANLKDAVAWLIAPSNPGESKSIENFISGIATHMTAFFDLALQDGDEKQFHLARELENGRIARSMMKLMTIIERAEPGGAQSWSETGERYQLKLFRDYVFHRVEADGKPNLAVGHMLSCLSKLDAGIDEMVVLTSRDNETVFVLSYRELKQMFDRAFNELVKHSKTGAPGANN

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

640 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

71.813 kDa

MAPLDLTRGQTDACSTENKDILCRNVLIYGHCRYEDQGCTYNHDQNKNSSQPEAPSKKMFNVDSPSFTPSGQSTVLPKKTTLSSQAASAAPFTPRGGGTPTLQTTAESTMFNPAAIREFTPQNYDLGNNNANGISQENGLYPDPFTMSTMGTALPTAGQYNLPLYGDHSGLAAPGAPFYPPHAAYPTGPIQPPHYHLYQPFGPYRQELQPWQRATYDFFMPQNLREDLQKKQFATLQVIPNSGLPQLEHWHSLVPLDTSNRKNTSCFGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVELQQEDFVKFGKLILSLATGTLPAHLNNIPAALETLGNKYSANLKSAVNWLLDTSSGETKTIEHFMTGIASQMTTFFDLALQDNDEKLFHLAREVENGRIARSLMKLLTILERGDYDGVPSWSETGDRYQLKLFRDYVFHRVDADGKPNLSIGHMLTCMSKLEAGVDENILLTSRDNETVFVLSYRELRQMYDRAFNELVKASKTGAPGANT

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

630 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

70.78 kDa

MNLNLDSAKDTLCKNILIYGYCKFENKGCAFSHHKPNVGQPPVSASSSSGYSGNSSPAEAKRKFNLNTPSFQPSNVQNITSKFAALSPKVKEIPVFVPSGGSGGAANTPNNGADANELLSQKKFNASTPSFMPAGFGSEYPSSPNTSGAGQPPNPYLTGNGHPASMAQSSGADVYYQQQAASYPLQYHLYAPAPPPRLTIPLPPHETNANSMFIPNDLRETLQKKNEATLQTLPRSNLPEHINIYHSLVPIDKSYDPKSKVWDVPSSLYKVFSSVDGNPYALRKIELNFPIINEAPFKTIKKWRSVKNANVTQLQEAFTSMAFGKSCLVVVYDYFPNSSTLIDHHKRIGTRTEPITEDLLWNYLVQLVNALMAIHAKGLAARSALDLTKIIVTNKNRIRLSNLAISDILNFEKDEEEISKSNRYFQGLQREDIKKLGRILLSLSTLTIPNTLRNNDTGELLRHLKTSSTISFSDEFIQVLTVLNEDTVEFDLDRFSQRYLTTRLFSTINNLEDSTDFMESQITTELENARLFRLLTKLNFIIDRPEAKDWTENSNKYIIKLFRDYIFFQHDEYGKPVVDLSRVLTNLNKLDAGIDEKFLLVSRDEKNCIIVSYKEIRDTIDSVFRNLTRD

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

620 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

68.973 kDa

MNINLDSAKGTLCKNILIYGYCKYENKGCAFSHRRNNNANSGPGATPAKSVATTPTSDKRKFNVNTPSFQPSTAPVQGLANKFAGLSPKVKDIPVFVPSGTPASPAQSTPSTGNQEQPMPTSTVSNVPERKFNTSTPSFTPSQPIPAPPPQNTSSPPTNPYLMNQPGPPTDMYYQSAYPLQYHLYAPAPPPRLAITHSSHQVDAHSLFIDSELRETLQKRNEATLQSYPGGPEIVDVYHTVVPIAAEGVSKIWKVSSSVYKGVSNVDGNVYALRKIEDFKIINETPFRTIKRWHGLQSANIVKIQDAFTTVAFGSPSLVVAYDYYPNASTLLEQHVNRRLGGRLEPLTEDILWLYLTQLVNAVRTVHKKKLAARSSLDLSKIIVTTNRIRLAAIGMSDILNWEADDAEIARVGLPTYMENLQQEDIRNMARLMVDLTTVMNPVVQNDIFKLKSSGLSTDFVAAVQDLSNTDDLESYIRKHLAIRLLDVVDMLEDSNDYLESQLSTELENARLVRLMTKINFIVDRPEWDNEATAAAAGWTENGPKYLLKLFRDFVFFQTDEMGKPVTDLSRVLVTLNKLDAGIDEKFLLVSRDEKTCIVVSYKEIRDLLESVFRTITRGK

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

612 amino acids

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.

Belongs to the protein kinase superfamily. PAN3 family.

67.391 kDa

MMMNKSKTDWAKDTPCKNITIYGYCKYENDGCIFNHGKPLSTSSNTGGAAAGSAEDSAASGGVTVGNTGKSTFNAKTATSFTPSVAIPDFNNIPSFTPERIVSSPAGDGATAFTPSFNPYGSDSFNPSANVSGPGSAVFAAASGNAGASATAAPRSQSVHVGTGGYLPLAGTAFPTVYPPSHSILQYHLYAPDPPPHLQVPLKANERTPETLFIPNNLREHLLKRNLSALQVFPSDGNLPDIVGDYFGLVPLEFHNRQTGKGRYLGHQNSLYKVFSNFDGKVYIIRRIHDVKTTDVGQISLPFRKWQKVSCPNVVKVKDAFTTLAFGDSSLCVVHDYYPQSNSLYETHVANYTVVPVTQKYLWSYLVQLSNALNEVHRHGLSMNNISLDKVIVTGDPGRIKVGDSAVHDILAFDEGRDIAKEQQADYSAVGALLMDLAQRMLGTRDQPLDSMDIDPLFKRVLAYLLSDEKKTIAEFTALFSHKMLDIISSSQTYSEYIEQHLSRELENGRLFRLMCKLNFIFGRMESSMDIHWSEAGDKFPIILFYDYVFHQVDENGKSVMDLTHVLRCLNKLDTGVSEKIILVTPDEMNCIIISYKELKDSIDSTFRSMTQ