pacc1

Proton-activated chloride channel

352 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH.

Belongs to the proton-activated chloride channel family.

40.977 kDa

MEAIRKELSRSYQELNEEAEPVAIDPEEAEDEEKEQEEAASAVAPDRDSDRSSPPVRFSRTCLKNFFSVLLILVYLLLMGVAVFLVYQTITDFRDKLKHPVMSVSYKEVNMYDAPGIALYPGKARLLSCEHHWYDHIPPLKDPGQPGENTCVTQDISYIDPYTNKTMKHALIVQGPRDVRRRELVFLQFHLNETKQDFSAIDYLLFSSYEAFLKSHDQVKFMQDCESSFSSWKFSGGFRTWVKMSLVKTKEEDGSQSVEFRQETSVVNFIDRRETPDKGDQLFFVVFEWKDPYIQEIQDIITANPWSMIALLCSVFLVLFKAADFAKLSVKWMIKVRRRHLKKRARELNHIS

PACC1

Proton-activated chloride channel

350 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling.

Belongs to the proton-activated chloride channel family.

40.135 kDa

MIRQELSTSYQELSEELDQVVENSEQADERDKETVKVHGPGILPALDSESASSSIRFSKACLKNVFSVLLIFIYLLLMAVAVFLVYQTIMDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHYYEVIPPLRSPGQPGDVNCTTQRVNYTDPFSNQTLKSALIVRGPREVQKRELVFLQFRLNQSSEDFSAIDYLLFSSFQEFLQSPDRAGFMQACESAYSSWKFSGGFRTWVKMSLVETKEEDGREAVEFRQETSVVNYIDQRPAAEKSAQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRRRYLKKRGQATNHIS

PACC1

Proton-activated chloride channel

350 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925).

Belongs to the proton-activated chloride channel family.

40.043 kDa

MIRQERSTSYQELSEELVQVVENSELADEQDKETVRVQGPGILPGLDSESASSSIRFSKACLKNVFSVLLIFIYLLLMAVAVFLVYRTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLTSPGQPGDMNCTTQRINYTDPFSNQTVKSALIVQGPREVKKRELVFLQFRLNKSSEDFSAIDYLLFSSFQEFLQSPNRVGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAKKSAQLFFVVFEWKDPFIQKVQDIVTANPWNTIALLCGAFLALFKAAEFAKLSIKWMIKIRKRYLKRRGQATSHIS

Pacc1

Proton-activated chloride channel

350 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925).

Belongs to the proton-activated chloride channel family.

40.178 kDa

MIRQELSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVPGVDNESASSSIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIAFYPGQAQLLSCKHHYEVIPPLASPGQPGDRNCTTQRINYTHPFFNHTMQSALIVQGPQEVKKRELVFLQFRLNQSNEDFSAIDYLLFSSFREFMQSPDKAGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAERSAQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRKRYLKRRGQATNHIS

PACC1

Proton-activated chloride channel

350 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling.

Belongs to the proton-activated chloride channel family.

40.014 kDa

MIRQERSTSYQELSEELDQVVENSELADEQDKETVKVQGPGVLPGLDSESASSSIRFSKACLKNVFPVLLIFIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLTSPGQPGDMNCTTQRINYTDPFSNQTVKSALIVQGPREVKKRELVFLQFRLNKSSEDFSAIDYLLFSSFQEFLQSPNRVGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAEKSAQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSIKWMIKIRKRYLKRRGQATSHIS

Pacc1

Proton-activated chloride channel

350 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling.

Belongs to the proton-activated chloride channel family.

40.073 kDa

MIRQDLSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVPGVDNESASSSIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLASPGQPGDRNCTTQRINYTHPFSNHTMQSALIVQGPQEVKKRELVFLQFRLNQSDEDFSAIDYLLFSSFREFMQSPDKAGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAEKSTQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRKRYLKRRGQATNHIS

pacc1

Proton-activated chloride channel

350 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH.

Belongs to the proton-activated chloride channel family.

40.659 kDa

MEAIRKELSRSYQELNDETDPIARDPEGAQEEEQEEAASAVVPDRDSDRSNTRVHFSRTCLKNVFSVLLIFVYLLLMGVAVFLVYQTITDFRDKLKHPVMSVSYKEVNVYDAPGIALYPGKARLLSCKHHLYDHIPPLIDPGQPGENTCITQNISYTDPYTNSTVKHALIVQGPRDVRRRELVFLQFHLNETKQDFSAIDYLLFSSYDAFLKSTNRVRFMQDCESSFSSWKFSGGFRTWVKMSLVKTKEEDGSQSVEFRQETSVVNFIDRRENPDKGDQLFFVVFEWKDPYIQEIQDIITANPWSMIALLCSVFLVLFKAADFAKLSVKWMIKVRRRHLKKRTRELNHIS

pacc1

Proton-activated chloride channel

298 amino acids

Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925). Displays channel activity with distinct kinetic properties compared to the human ortholog channel (PubMed:31023925).

Belongs to the proton-activated chloride channel family.

34.687 kDa

MPIGFNKACLKNVFTVILVLIYLALTAVAVFLAYQTISDFMDKLNHPVMSVSYKEVEEFAAPGIVLFPGKAHLLSCMHHYHDNIPPLVALENLAKRECMKEEVIYHGPYSNQTEKRALVFRGPTDVRNRELIFLQLSRNETEEDFSAISYMIFAKFSDMLESSDKAAFMMDCERNYSMWTFSGGFRTWVKMSLVRTSGRRNESVEFRQESSVVKYIDKRPPLEQTNELFFIVFQWRDPFIQQVKDIVTANPWNTIAILCGVFMALFKAADFAKLSIKWMIRIRKRHIRAKMREMNQIS