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PAAF1

Gene
paaf1
Protein
Probable proteasomal ATPase-associated factor 1
Organism
Dictyostelium discoideum
Length
425 amino acids
Function
Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core.
Similarity
Belongs to the WD repeat PAAF1/RPN14 family.
Mass
47.096 kDa
Sequence
MTSNTTEIPYHFLPYVRIQYDWQLAYKQDSDNCWVAYQKDLKNTIHGSVHSTKIDENNFKFESDYGFKLTPNKENKNNIRVENDKYSIEIYAPEKQLKVSGGKKRITSMGVSHLGELGVYGSTDGTLEVFETGDGQIRRKLDGHVGDVDLAMFFPSGRVILSGSSDSRLKIWDAIEGTCASTLVGHIGGITSASLVDRGRNLVSCSRDGTSKLWDIPTSSIISNLTKLSRPINDSFIASSLLDSIPTTTTTNSNDNNKVDEREVGTDGKTLIIAAEEGFLQAIDLRSKNMISQMNVVQSGEKSTRSVAFNACHVHKNYIIGGDHNGSIYFWDKRNLNSPFCRLQFTNSPIHHIKANSSNSKIANSIWVTSGDGCCFLLDLDKNQIITSLSGIDTDVVTSFNIVGNQAYLTSRDSIIRCYNNLLNI

Gene
PAAF1
Protein
Proteasomal ATPase-associated factor 1
Organism
Bos taurus
Length
392 amino acids
Function
Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core. Protects SUPT6H from proteasomal degradation (By similarity).
Similarity
Belongs to the WD repeat PAAF1/RPN14 family.
Mass
42.194 kDa
Sequence
MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPTLYGSLTCQGIGLDGIPEVTASEGFIVNEINKKSIHVSCPKENVSSKFLAPYTTFSRIHTKSITCLDISSGGGLGVSSSADGSMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGKNVVSGSRDGTARLWDCGRSACLGVIADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTESKMLLLAREDKKLQCLGLQSRQPLFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRNPRTPVQVIHRSGAPVMSLLSFRDGFIASQGDGSCFIVQQDLDYVIELTGADCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL

Gene
PAAF1
Protein
Proteasomal ATPase-associated factor 1
Organism
Gallus gallus
Length
392 amino acids
Function
Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core.
Similarity
Belongs to the WD repeat PAAF1/RPN14 family.
Mass
42.373 kDa
Sequence
MAATLRIQSDWSQALRRDEGEAWLSCRSPGKPTLYGSLTRRGLSTEGVPDIAASEGFVVGEVTKKSILISCPHENVSTKFLAPYTTFSRIHQKSITCLDISSGGGLGVSTSTDGTMKIWQAANGEIRRLLEGHVYDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVLSCSRDGTARLWDCGKSSCLAVIADCGSPINGIAVGTADDSVNLGTPEKAPSEREIGTEGKILLLAREDKKLQGVGLQSRQPVFLFDGSDAFNCCTFLSSTYFLAGTQDGNIYQLDVRNTNAPIQIIHRSGAPVLSLLPYRDGFIASQGDGTCFIVQQDLDYVIDLTEADCDPVYKVAPWEKQIYTCCRDGVVRRYQLGDL

Gene
PAAF1
Protein
Proteasomal ATPase-associated factor 1
Organism
Homo sapiens
Length
392 amino acids
Function
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.
Similarity
Belongs to the WD repeat PAAF1/RPN14 family.
Mass
42.19 kDa
Sequence
MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVNEINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGADCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL