Protein
Putative 4-hydroxythreonine-4-phosphate dehydrogenase 2
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
Similarity
Belongs to the PdxA family.
Sequence
MNAPSLPRLAMVLGDPAGIGPELIARLLADTEVREKAHIVLIADEAEMRRGMRIAGCEFPYRRIDALETLDFADATPLLHPWLSQGGDEFPRSEASAVGGRYSLETLALALELTRSGRTDAILFGPLNKTSLHMAGMDHSDELHWFAERLGFGGPFCEFNVLDDLWTSRVTSHVALAEVPGLLSQERVGEAIRLIDDALRRSGLARPRIGVCGLNPHNGDNGSFGREELDIIAPAVQKAREQGIAADGPYPADTIFLKVQGDARAFDAVVTMYHDQGQIAIKLMGFSRGVTVQGGLPIPIATPAHGTAFDIAGQGRADVGATRQAFEIACRMGRHKA