Protein
Octopamine receptor beta-3R
Organism
Drosophila melanogaster
Function
Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed:25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed:25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed:25605909).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Sequence
MSGVNVADLLATTMTLPITAAAGAATSQAAATSATNASHLQPATLTGHISTTAAAKTTTTPTSSLPITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIISGPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQHSDTDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGESPQQPATPPPSLSPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCANYLMSPPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTSLPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSGNGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTANATATANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAKGWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVLFWIGYFNSTLNPLIYAYFNRDFREAFRNTLECVLPCLEKRNPYNAYYV