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OXA1

Gene
OXA1
Protein
Mitochondrial inner membrane protein OXA1
Organism
Arabidopsis thaliana
Length
429 amino acids
Function
Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for activity and assembly of cytochrome c oxidase.
Similarity
Belongs to the OXA1/ALB3/YidC (TC 2.A.9.2) family.
Mass
47.86 kDa
Sequence
MAFRQTLSIRSRLFARRNQPVYHIIPRESDHERDSFCQETSQRSYHSFLHQRSVNNSDFSKVSGGSLHLPLAPTSGFAFYRYMSSAPGVGSEKIGVMSDIAEVITDSTLQDVPAQAAAAVSEVTLAAADSFFPIAALQQCIDMVHTFTGFEWWASIVVATILIRSSTVPLLIKQMKDTTKLALMRPRLESIREEMQNKGMDSVTMAEGQKKMKNLFKEYGVTPFTPMKGMFIQGPLFICFFLAIRNMAEKVPSFQTGGALWFTDLTTPDSLYILPVITGLTFLITVECNAQEGMEGNPMAGTVKTVCRVFALLTVPMTMSFPQAIFCYWITSNLFSLMYGLVIKRPQVKKMLRIPDLPPPPPGQQPSFDLFSALKKMKAMTQDHTQNQIEPPSPVNPRLSSTSLSPVSKRLKALESQVKGRKKNSSKKK

Gene
OXA1
Protein
Mitochondrial inner membrane protein OXA1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
402 amino acids
Function
Mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. Links mitoribosomes with the inner membrane (PubMed:22904327). Forms pores capable of accommodating translocating protein segments (PubMed:22829595). Essential for the activity and assembly of cytochrome c oxidase (PubMed:22904327). Plays a central role in the translocation and export of the N-terminal part of the COX2 protein into the mitochondrial intermembrane space.
Similarity
Belongs to the OXA1/ALB3/YidC family.
Mass
44.816 kDa
Sequence
MFKLTSRLVTSRFAASSRLATARTIVLPRPHPSWISFQAKRFNSTGPNANDVSEIQTQLPSIDELTSSAPSLSASTSDLIANTTQTVGELSSHIGYLNSIGLAQTWYWPSDIIQHVLEAVHVYSGLPWWGTIAATTILIRCLMFPLYVKSSDTVARNSHIKPELDALNNKLMSTTDLQQGQLVAMQRKKLLSSHGIKNRWLAAPMLQIPIALGFFNALRHMANYPVDGFANQGVAWFTDLTQADPYLGLQVITAAVFISFTRLGGETGAQQFSSPMKRLFTILPIISIPATMNLSSAVVLYFAFNGAFSVLQTMILRNKWVRSKLKITEVAKPRTPIAGASPTENMGIFQSLKHNIQKARDQAERRQLMQDNEKKLQESFKEKRQNSKIKIVHKSNFINNKK

Gene
OXA1
Protein
Mitochondrial inner membrane protein OXA1
Organism
Kazachstania servazzii
Length
371 amino acids
Function
Probably required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase (By similarity).
Similarity
Belongs to the OXA1/ALB3/YidC family.
Mass
42.049 kDa
Sequence
MGVANTSLRYSAFNFSLGRRFKSTSETLNDLPETISEVQTQLPSIDQMTNATADIVEQASHSVGELSTHIGYLNSIGLAQTWHWPADIIQHALEYVHVYTGLPWWGTICTVTILVRLLMFPIYVKSSDTIAKNSRIKPQMDKVTKELMATTDLAEGQKIAVRRRKLLSENGIKNRWLAAPMLQLPIAIGFFNALRSMANFPVDGFANQGILWFHDLTLSDPYLGLQFITAAVLMSFSRLGGETGAQQFSGPMKRFFIILPLVSIPATMNLSTSVVLYFAINGTFSVLQTLVLRNKWFRKKLNIAEVVQHPPDPTKENSGIFAAIKENMNTARERSEKRKLMKEEEERVHELIKKKRTNERIRIIRRPELKK