ORF9

DNA polymerase catalytic subunit

1012 amino acids

Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).

Belongs to the DNA polymerase type-B family.

113.326 kDa

MDFFNPFIDPTRGGPRNTVRQPTPSQSPTVPSETRVCRLIPACFQTPGRPGVVAVDTTFPPTYFQGPKRGEVFAGETGSIWKTRRGQARNAPMSHLIFHVYDIVETTYTADRCEDVPFSFQTDIIPSGTVLKLLGRTLDGASVCVNVFRQRCYFYTLAPQGVNLTHVLQQALQAGFGRASCGFSTEPVRKKILRAYDTQQYAVQKITLSSSPMMRTLSDRLTTCGCEVFESNVDAIRRFVLDHGFSTFGWYECSNPAPRTQARDSWTELEFDCSWEDLKFIPERTEWPPYTILSFDIECMGEKGFPNATQDEDMIIQISCVLHTVGNDKPYTRMLLGLGTCDPLPGVEVFEFPSEYDMLAAFLSMLRDYNVEFITGYNIANFDLPYIIARATQVYDFKLQDFTKIKTGSVFEVHQPRGGSDGGNFMRSQSKVKISGIVPIDMYQVCREKLSLSDYKLDTVAKQCLGRQKDDISYKDIPPLFKSGPDGRAKVGNYCVIDSVLVMDLLLRFQTHVEISEIAKLAKIPTRRVLTDGQQIRVFSCLLEAAATEGYILPVPKGDAVSGYQGATVISPSPGFYDDPVLVVDFASLYPSIIQAHNLCYSTLIPGDSLHLHPHLSPDDYETFVLSGGPVHFVKKHKRESLLAKLLTVWLAKRKEIRKTLASCTDPALKTILDKQQLAIKVTCNAVYGFTGVASGILPCLNIAETVTLQGRKMLERSQAFVEAISPERLAGLLRRPVDVSPDARFKVIYGDTDSLFICCMGFNMDSVSDFAEELASITTNTLFRSPIKLEAEKIFKCLLLLTKKRYVGVLSDDKVLMKGVDLIRKTACRFVQEKSSQVLDLILREPSVKAAAKLISGQATDWVYREGLPEGFVKIIQVLNASHRELCERSVPVDKLTFTTELSRPLADYKTQNLPHLTVYQKLQARQEELPQIHDRIPYVFVDAPGSLRSELAEHPEYVKQHGLRVAVDLYFDKLVHAVANIIQCLFQNNTSATVAILYNFLDIPVTFPTP

ORF9

Putative ATP-dependent RNA helicase

978 amino acids

Belongs to the DEAD box helicase family. DEAH subfamily.

110.798 kDa

MKFNFCLVFFPCPCYFSTVVYYVNEQCTMLKYALPLYPVVDAIDESWSYEHLDKLTKYNEFTDTQLLYSNDDVRDFNNTSRVPMPHQVLVANYTTPKSPVEGVLVVHGVGTGKTMTAILAMLNNINVPGGLKRGLVLTPNRAVLSAFRDELHAYYKSRFSDRHVNEFEMEKYLSETFAFNTITSFANTIDRTADVVLHKEWNATFVVIDEAHDLTMQGVDYPKINGFLKLLTSRKILLLTATPMRNNISDLVPLHNLLMRNRTHDITVEQFNRDMVVRINDVNDVYTVEKPNEYFRRKFAGLVSYLPSNGRDALDVNIVQVGRTGVYGLKYTHVVEHDMSDDMAMVYRTVDDATRNDRDVALLRQRQVSRFVFPDGTYGTTGYQSWMDSKTGRPKRKLLDALRGGASDRAAILDNVAKYSPRYAWIARNVIEAAERGEKSMVYDDLVTGSGLLVFAAVLEALGLERGTGKGAGSFLCLTREVMTVNAIVSAIKNIQQRQQLRRFRGRYRVRFASHRRSITLKDVIHEHVVAHRNDAETEQIIGRGIRYKSHANTIANWKSSTRPNVFIYRHATVDSRSPNTRTVDILMLATSERKRLNINSAISALSSVALTCNGCNPSSQTPPVPPAYRGYYKGVDVSDDNTIPLDPPRITNSFIVKLDEEFDFRRQNVTVKVDSLLKLFNLDPSSVEALKMLFVIMNTIQTHGQLDVDKYIDCNGQYVTISKCVDEFRQRPTFVYPYLVRNTSVYGVGVYRDALAESVITPNMMRDIERSVTTFPYPIDKLPVMVLQGLLETAIVTKGVRDPYNTLGDMVQYYAYGDNDPDVEAAVWLALAAGEGQDYRILTTVGEDGVRRDRYWINCPNRYVDRVVRMKSEREAQINDMVRSKRLKYYGTKNPTTGDFCIRTVPDGSPTNRRCVLTGRKCVTWTSSKLREIGSGVGVRVAANSPRKATCSAIEQEFGRLDALFAYVSCGVQAKRK

ORF9

Putative RING finger protein ORF9

592 amino acids

69.115 kDa

MACSKMSVDLECCICLEEDIERVDTIPCQHTVCRPCYLKPMINKCPVCRVRWIARERDPLAKDYTGEHYAHTYGFFAVNIDEESEEEEEEQVIEEEPQTPEIDPEEIELPRRFVDERIEYFLATGLRIDYVLTRGYCPSIQADEQEVLYLPLYTIYCNAYDANDDILHGQEIEITIQITRGECGSGWCEAQFVYVSITDSEDSGPKPITHSVKGGIGAVRFSREEIEFELQTPLPIESRTSYSHFEWEITTPYFKINQTGEELYPWAVLDFYEEEFWEPIVEPLDGPVDVDMSSYSAIGGIASMLRVTAAARRDNDEQYNEIIGRHVSRKVLNGGAEKDYIYLREINGKEFSIYDKIGNCFVGTNKTGITLPFTHVPSPAAIRGNHHILKEPEYIYGEERDTSYETALQSFDDWELIKREELLQRRYKREEQNLKYTSNRLFYFEKEFEEIMEDKWAIESYMCEDDDNTKPEYTTDMRVACEQRDRHGTDIVKCRLDKEVGSRRMHTLIDGESGVGKSFLAGHLSRGLVFDLDWITPNEDGSKPELPEDLHYPIIILGKRFDYDMREITKRLLYKKEYVVVKLSYMYFFYCI

ORF9

Tegument protein VP22

302 amino acids

Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein ORF17 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.

Belongs to the alphaherpesvirinae VP22 tegument protein family.

32.846 kDa

MASSDGDRLCRSNAVRRKTTPSYSGQYRTARRSVVVGPPDDSDDSLGYITTVGADSPSPVYADLYFEHKNTTPRVHQPNDSSGSEDDFEDIDEVVAAFREARLRHELVEDAVYENPLSVEKPSRSFTKNAAVKPKLEDSPKRAPPGAGAIASGRPISFSTAPKTATSSWCGPTPSYNKRVFCEAVRRVAAMQAQKAAEAAWNSNPPRNNAELDRLLTGAVIRITVHEGLNLIQAANEADLGEGASVSKRGHNRKTGDLQGGMGNEPMYAQVRKPKSRTDTQTTGRITNRSRARSASRTDTRK

ORF9

Tegument protein VP22

302 amino acids

Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein ORF17 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.

Belongs to the alphaherpesvirinae VP22 tegument protein family.

32.816 kDa

MASSDGDRLCRSNAVRRKTTPSYSGQYRTARRSVVVGPPDDSDDSLGYITTVGADSPSPVYADLYFEHKNTTPRVHQPNDSSGSEDDFEDIDEVVAAFREARLRHELVEDAVYENPLSVEKPSRSFTKNAAVKPKLEDSPKRAPPGAGAIASGRPISFSTAPKTATSSWCGPTPSYNKRVFCEAVRRVAAMQAQKAAEAAWNSNPPRNNAELDRLLTGAVIRITVHEGLNLIQAANEADLGEGASVSKRGHNRKTGDLQGGMGNEPMYAQVRKPKSRTDTQTTGRITNRSRARSASRTDARK

ORF9

Protein P20A

177 amino acids

19.586 kDa

MKLLSLRYLILRLSKSLRTNDHLVLILIKEALINYYNASFTDEGAVLRDSRESIENFLVARCGSQNSCRVMKALITNTVCKMSIETARSFIGDLILVADSSVSALEEAKSIKDNFRLRKRRGKYYYSGDCGSDVAKVKYILSGENRGLGCVDSLKLVCVGRQGGGNVLQHLLISSLG

ORF9

Putative zinc-binding protein ORF9

158 amino acids

17.082 kDa

MATRPKVRRPDRALYVPPKVDRIKRVIFACGHRKRCEIGYRPLGDSGNCGPCGARRDVFAPDLYGSGPLPPCPVCGRAVVGPTVREACGHVTCNACETEACAVDRLCIGGGRRLVAICDPYPPYPGPRWRGPRPTRPEAHEAVQRSRGSSEDACTCAP

ORF9

Uncharacterized protein 9

123 amino acids

12.543 kDa

MGGGGPPARVQGTEGSQTGGGAVAVSYHPNNLDTKPLSCLPILSNFLLISSNSSLTSSTSSPLLMSSRYASAVEIPSSSAYSSTNSIVASLSRIDTTSFELLMVSRLRSSTPGKPFCSVPSVA

ORF9

Putative capsid protein ORF9

78 amino acids

May self assemble to form a helical capsid wrapping up the viral genomic DNA. The virion assembly and budding take place at the host inner membrane (By similarity).

Belongs to the plectrovirus ORF9 family.

8.761 kDa

MIKLVLLVAAIAIFGTGFITVIINQFTSAKNIIMDLYNSDTWLIWLFGRMAVLFSHPLMLTISSLYIVGFIVSKTLYS

ORF9

Putative capsid protein ORF9

78 amino acids

May self assemble to form a helical capsid wrapping up the viral genomic DNA. The virion assembly and budding take place at the host inner membrane (By similarity).

Belongs to the plectrovirus ORF9 family.

8.761 kDa

MIKLVLLVAAIAIFGTGFITVIINQFTSAKNIIMDLYNSDTWLIWLFGRMAVLFSHPLMLTISSLYIVGFIVSKTLYS

ORF9

Uncharacterized protein ORF9

57 amino acids

6.592 kDa

MSQMSIFRKADVLSQTMTATIDVGRIENKETYEYYLKSHGFEVTKETDTIWAVKATQ

ORF9

Uncharacterized protein ORF9

28 amino acids

3.776 kDa

MAYRGFKTSRVVKHRVRRRWFNHRRRYR