ORF59

Uncharacterized protein ORF59

1080 amino acids

121.65 kDa

MHKLLVIIAHIIVCAYADFTGFDNEAGAVENNNDNNINLEYKPPTLRHGAGISCVIRPGDFTHVAISNDFFNRANLPAGFVNVNLEVTDFASSARCKAQLESLAPDDTLTTLITGAANCEIDQGGVTMVVYLKKNPEEIYLKNWRCGYKGSGDYVYKTLALQKTIKGQWGDSTDADSPIHPPLITLAARVETSTETEITLTCQRNNRGVTTTYFTGAPFKTVEFTGAENFRAKGDLYGRDLTPSVVPQCVINTPGDPVFKFKNLGPEDYSSKCYSGFLSTTLPEIKPKFTLLRNPYDVDFNGYEPNDVTMDFDTDSLFLFDRNVNMDRVVIDKHPYMVMKFLKPRNFHETPLLNHVDPNQPKHTFMTSISFTMLNLLLGQQLHKATAIQTVEVIKNSGDSASITCPFDSSVEEYLAIFLLDTSTCSVSLSNRNDVVQYNNSCVDPTNFYLLSSRSTSNDQTFTIDLTGNEACISKYATCIYKKKVPGITNILLLPADFASRDKIPDLSDKDVEDTDNCEEDPGLIKTLERGIRLLTFSDSYSYDYHLDQYNVLTGDGCAQLINPCEYDTTASAMKELGRVASVRVPIRFLNKFPDKKIWQCSMYDTDSDKMSWNEMRDNVACSGTELYKSLITPPKPSVYRSDENNFKISCGIIHRSCINKGINTSAVLSGTEIEDTLLEEGEEFTISQYDLLIKNKVLKCETEWGVGESFISDLLPTNSGCSVSGSCVFIDMNTIRCFYDSKNCYSHNINNVKVVFRINDADVPGANVKLSETNRFEDGFFHFLYPVASIVSIPTKNTIGFKLVDEWQRETDEFTVPYPTVEQWAFILESGIECDYTELSSAVLDVSMGRYTGETTITLQYDMYNFPECKTNENETSVDYYLQIRGEIGTSRARREDEDKSMTEWKNLVYISVHDDGDGVVTWQPISNQRDYNLDIFDNKILAAFRYRLTQEKITELFGPYINSLEVRVITESLDKGVYEATKEYLDQTMAYRTLMIPRIPPQPPITTATTQPPIDVMITTQSPNKPTEDEKSLDLEMIGKIILLIAFVIVFVILLTIGIITLVKRHRETLPEDEYLLP

ORF59

DNA polymerase processivity factor

396 amino acids

Plays an essential role in the viral lytic DNA replication by acting as the polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template (By similarity).

Belongs to the herpesviridae DNA polymerase accessory subunit family.

42.378 kDa

MPVDFHYGVRVDVTLLSKIRRVNEHIKSATKTGVVQVHGSACTPTLSVLSSVGTAGVLGLRIKNALTPLVGHTEGSGDVSFSFRNTSVGSGFTHTRELFGANVLDAGIAFYRKGEACDTGAQPQFVRTTISYGDNLTSTVHKSVVDQKGILPFHDRMEAGGRTTRLLLCGKTGAFLLKWLRQQKTKEDQTVTVSVSETLSIVTFSLGGVSKIIDFKPETKPVSGWDGLKGKKSVDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVPTGCQSGDVKLSVLLLEVNRSVSAEGGESSQKVPDSIPDSRRQPELESPDSPPLTPVGPFGPLEDASEDAASVTSCPPAAPTKDSTKRPHKRRSDSSQSRDRGKVPKTTFNPLI

ORF59

Putative membrane protein ORF59

345 amino acids

38.135 kDa

MVGKGLPVLKNALKQLEGLSKAASVGTAEVIQKAYHQLTKLQAARLVFAYVTLVLLYVIMMLILTSSVIDLVGFSTPHRLPPFVDQAQLKHFNTAQDTLMIVFVALGVNFLLVILVFLIYLLIKLKHIEAPLSGSMSYFAHPVLKYIFGIMSFIFVFIITVFSILRITCADANTLVQDLELLSNTSFADTNFTNAAHAAVSGLLTNCTAPHTDIAKCGYSGVHLLMSLESRTRRLWTGSTSGGLTEAGIPRMLTAVGSCWMTKEVVPVILLVMFILYMFLHLWMVIRALRRRRLGTIIEDEHLPLTSYEDGELDEEGGADNLLYAIPPGSTIPGMRKWNYTPARA

ORF59

Uracil-DNA glycosylase

305 amino acids

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.

34.376 kDa

MDVSGEPTVCSNAYANEMKLSDSKDIYVLAHPVTKKTRKRPRGLPLGVKLDPPTFKLNNMSHHYDTETFTPVSSQLDSVEVFSKFNISPEWYDLLSDELKEPYAKGIFLEYNRLLNSGEEILPSTGDIFAWTRFCGPQSIRVVIIGQDPYPTAGHAHGLAFSVKRGITPPSSLKNIFAALMESYPNMTPPTHGCLESWARQGVLLLNTTLTVRRGTPGSHVYLGWGRLVQRVLQRLCENRTGLVFMLWGAHAQKTTQPNSRCHLVLTHAHPSPLSRVPFRNCRHFVQANEYFTRKGEPEIDWSVI

ORF59

Uracil-DNA glycosylase

305 amino acids

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.

34.36 kDa

MDVSGEPTVCSNAYANEMKLSDSKDIYVLAHPVTKKTRKRPRGPPLGVKLDPPTFKLNNMSHHYDTETFTPVSSQLDSVEVFSKFNISPEWYDLLSDELKEPYAKGIFLEYNRLLNSGEEILPSTGDIFAWTRFCGPQSIRVVIIGQDPYPTAGHAHGLAFSVKRGITPPSSLKNIFAALMESYPNMTPPTHGCLESWARQGVLLLNTTLTVRRGTPGSHVYLGWGRLVQRVLQRLCENRTGLVFMLWGAHAQKTTQPNSRCHLVLTHAHPSPLSRVPFRNCRHFVQANEYFTRKGEPEIDWSVI

ORF59

Uncharacterized protein ORF59

242 amino acids

Belongs to the ascovirus HvAV ORF59 family.

26.669 kDa

MTRRLTNDDMNRILQIVKAHMFKPKQTLARDINGIAVSVNAKVGETPDLSSFSQEEISKLIEEDGWDVATTQEVYRILSETVKIMNGAGAAGGAVVPKLYPALMSPNTITNVIPDARSGVPSTDRTIIGDMGSLQGPEGGEWLAFFYPAHTVFDKMRMTSVVLNFSSPLTGEYVLQMLNALNPTKSVRDIHKFNGSKSSVMVIGLSEVFMQQTSVTFRLQPAPLDVKGGRPMVRMELHFEFM

ORF59

Uncharacterized 8.0 kDa protein

68 amino acids

7.969 kDa

MKKVSLGKIIESTVEDKYTYRFVRDQKKPNLGEYYKTFESIRAGQHSSTYDVVGKRDYTVVDKLVKKC

ORF59

Uncharacterized protein ORF59

59 amino acids

6.856 kDa

MYLFYVLLSSLFLSALIYVIGKSHPNLFMFISLFVNVVTILYLVFKDYGQYIIAKPINT