Protein
Replication origin-binding protein
Organism
Varicella-zoster virus (strain Oka vaccine)
Function
Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication (By similarity).
Similarity
Belongs to the herpesviridae OriBP family.
Sequence
MSPNTGESNAAVYASSTQLARALYGGDLVSWIKHTHPGISLELQLDVPVKLIKPGMSQTRPVTVVRAPMGSGKTTALLEWLQHALKADISVLVVSCRRSFTQTLIQRFNDAGLSGFVTYLTSETYIMGFKRLIVQLESLHRVSSEAIDSYDVLILDEVMSVIGQLYSPTMRRLSAVDSLLYRLLNRCSQIIAMDATVNSQFIDLISGLRGDENIHTIVCTYAGVGFSGRTCTILRDMGIDTLVRVIKRSPEHEDVRTIHQLRGTFFDELALRLQCGHNICIFSSTLSFSELVAQFCAIFTDSILILNSTRPLCNVNEWKHFRVLVYTTVVTVGLSFDMAHFHSMFAYIKPMSYGPDMVSVYQSLGRVRLLLLNEVLMYVDGSRTRCGPLFSPMLLNFTIANKFQWFPTHTQITNKLCCAFRQRCANAFTRSNTHLFSRFKYKHLFERCSLWSLADSINILQTLLASNQILVVLDGMGPITDVSPVQFCAFIHDLRHSANAVASCMRSLRQDNDSCLTDFGPSGFMADNITAFMEKYLMESINTEEQIKVFKALACPIEQPRLVNTAILGACIRIPEALEAFDVFQKIYTHYASGWFPVLDKTGEFSIATITTAPNLTTHWELFRRCAYIAKTLKWNPSTEGCVTQVLDTDINTLFNQHGDSLAQLIFEVMRCNVTDAKIILNRPVWRTTGFLDGCHNQCFRPIPTKHEYNIALFRLIWEQLFGARVTKSTQTFPGSTRVKNLKKKDLETLLDSINVDRSACRTYRQLYNLLMSHRHSFSQQRYKITAPAWARHVYFQAHQMHLAPHAEAMLQLALSELSPGSWPRINGAVNFESL