About Products Protein Database Contact

ORF37

Gene
ORF37
Protein
Uncharacterized protein ORF37
Organism
Ictalurid herpesvirus 1 (strain Auburn)
Length
670 amino acids
Mass
75.416 kDa
Sequence
MSGVKLGSFALSISYTCVFVNLRRKKPIMAMYRLGHQQQHVPNTDISIFRDKVPYTPTVDDAALNKLIMIIRETYGLPKYTIRLISGTTFWAVIKNIYDNDRVFGNTTSEMMNGLDLVYAIDDFCTKQLLEMFPEHVTDMQHLAGAMSKSLGRTGFYRHLTETFKRHMLWSVLTNFSPVAYYPAADIARADEACDLVTRATVDRLRKTEETVLADERFRGLLGPEMVARLLKVIPGIPPDTARSIGLVFDNIRPKLSTEAARTLGGMLIETLRRQYSGYLPVAPLVDLTETVMVYVHEVDTCLLMDKRGRVFRALGEPISRSQPLSSPVARTSESTMKFQALFDDYMRAASMNAKRTVVTAPQTVAAQESRNPFTRELDSGQLSRATFENLIQLTGQLNYHQRTAIAESSGLVANPTMVSPTNTALAHMLRTNGAAIQESMLDDLNSRINDLTDQSRRFTDLKRVIGLLQSRDFETLAVHVGELHPDDRELVLHALGPSTRSAAQIDPPEIHRLPENTKLLCSFTTSINLPEIEELLHLWTITWETVFCGRNLFTRRKHALQYTTTGRHDNEPSQSIQFMFVDSLNAPGVLMDRLYPSKVTKLTFTELMVLSEKVETVTLPEIFAAQIGLNPSEVRLKNRDACEPPREIVTGVNHELGVDGRFRVAMEDV

Gene
ORF37
Protein
Shutoff alkaline exonuclease
Organism
Human herpesvirus 8 type P (isolate GK18)
Length
486 amino acids
Function
Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response. Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1. Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation.
Similarity
Belongs to the herpesviridae alkaline nuclease family.
Mass
55.076 kDa
Sequence
MEATPTPADLFSEDYLVDTLDGLTVDDQQAVLASLSFSKFLKHAKVRDWCAQAKIQPSMPALRMAYNYFLFSKVGEFIGSEDVCNFFVDRVFGGVRLLDVASVYAACSQMNAHQRHHICCLVERATSSQSLNPVWDALRDGIISSSKFHWAVKQQNTSKKIFSPWPITNNHFVAGPLAFGLRCEEVVKTLLATLLHPDEANCLDYGFMQSPQNGIFGVSLDFAANVKTDTEGRLQFDPNCKVYEIKCRFKYTFAKMECDPIYAAYQRLYEAPGKLALKDFFYSISKPAVEYVGLGKLPSESDYLVAYDQEWEACPRKKRKLTPLHNLIRECILHNSTTESDVYVLTDPQDTRGQISIKARFKANLFVNVRHSYFYQVLLQSSIVEEYIGLDSGIPRLGSPKYYIATGFFRKRGYQDPVNCTIGGDALDPHVEIPTLLIVTPVYFPRGAKHRLLHQAANFWSRSAKDTFPYIKWDFSYLSANVPHSP

Gene
ORF37
Protein
Uncharacterized protein ORF37
Organism
Ostreid herpesvirus 1 (isolate France)
Length
76 amino acids
Mass
9.082 kDa
Sequence
MIFFTRNHRAINAHFLYDHNDRQILNRQFPPDNITMEERAVIKSVGRELSRIMCIVETNVLTRAGGYFSIFYRDFD

Gene
ORF37
Protein
Uncharacterized protein ORF37
Organism
Acidianus bottle-shaped virus (isolate Italy/Pozzuoli)
Length
37 amino acids
Mass
4.064 kDa
Sequence
MTVEGLTILRSPTFLTIIVLLMIVFGIAIVALLTQYV