ORF28

DNA polymerase catalytic subunit

1194 amino acids

Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).

Belongs to the DNA polymerase type-B family.

134.048 kDa

MAIRTGFCNPFLTQASGIKYNPRTGRGSNREFLHSYKTTMSSFQFLAPKCLDEDVPMEERKGVHVGTLSRPPKVYCNGKEVPILDFRCSSPWPRRVNIWGEIDFRGDKFDPRFNTFHVYDIVETTEAASNGDVSRFATATRPLGTVITLLGMSRCGKRVAVHVYGICQYFYINKAEVDTACGIRSGSELSVLLAECLRSSMITQNDATLNGDKNAFHGTSFKSASPESFRVEVIERTDVYYYDTQPCAFYRVYSPSSKFTNYLCDNFHPELKKYEGRVDATTRFLMDNPGFVSFGWYQLKPGVDGERVRVRPASRQLTLSDVEIDCMSDNLQAIPNDDSWPDYKLLCFDIECKSGGSNELAFPDATHLEDLVIQISCLLYSIPRQSLEHILLFSLGSCDLPQRYVQEMKDAGLPEPTVLEFDSEFELLIAFMTLVKQYAPEFATGYNIVNFDWAFIMEKLNSIYSLKLDGYGSINRGGLFKIWDVGKSGFQRRSKVKINGLISLDMYAIATEKLKLSSYKLDSVAREALNESKRDLPYKDIPGYYASGPNTRGIIGEYCIQDSALVGKLFFKYLPHLELSAVARLARITLTKAIYDGQQVRIYTCLLGLASSRGFILPDGGYPATFEYKDVIPDVGDVEEEMDEDESVSPTGTSSGRNVGYKGARVFDPDTGFYIDPVVVLDFASLYPSIIQAHNLCFTTLTLNFETVKRLNPSDYATFTVGGKRLFFVRSNVRESLLGVLLKDWLAMRKAIRARIPGSSSDEAVLLDKQQAAIKVVCNSVYGFTGVAQGFLPCLYVAATVTTIGRQMLLSTRDYIHNNWAAFERFITAFPDIESSVLSQKAYEVKVIYGDTDSVFIRFKGVSVEGIAKIGEKMAHIISTALFCPPIKLECEKTFIKLLLITKKKYIGVIYGGKVLMKGVDLVRKNNCQFINDYARKLVELLLYDDTVSRAAAEASCVSIAEWNRRAMPSGMAGFGRIIADAHRQITSPKLDINKFVMTAELSRPPSAYINRRLAHLTVYYKLVMRQGQIPNVRERIPYVIVAPTDEVEADAKSVALLRGDPLQNTAGKRCGEAKRKLIISDLAEDPIHVTSHGLSLNIDYYFSHLIGTASVTFKALFGNDTKLTERLLKRFIPETRVVNVKMLNRLQAAGFVCIHAPCWDNKMNTEAEITEEEQSHQIMRRVFCIPKAILHQS

ORF28

DNA polymerase catalytic subunit

1194 amino acids

Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).

Belongs to the DNA polymerase type-B family.

134.117 kDa

MAIRTGFCNPFLTQASGIKYNPRTGRGSNREFLHSYKTTMSSFQFLAPKCLDEDVPMEERKGVHVGTLSRPPKVYCNGKEVPILDFRCSSPWPRRVNIWGEIDFRGDKFDPRFNTFHVYDIVETTEAASNGDVSRFATATRPLGTVITLLGMSRCGKRVAVHVYGICQYFYINKAEVDTACGIRSCSELSVLLAECLRSSMITQNDATLNGDKNAFHGTSFKSASPESFRVEVIERTDVYYYDTQPCAFYRVYSPSSKFTNYLCDNFHPELKKYEGRVDATTRFLMDNPGFVSFGWYQLKPGVDGERVRVRPASRQLTLSDVEIDCMSDNLQAIPNDDSWPDYKLLCFDIECKSGGSNELAFPDATHLEDLVIQISCLLYSIPRQSLEHILLFSLGSCDLPQRYVQEMKDAGLPEPTVLEFDSEFELLIAFMTLVKQYAPEFATGYNIVNFDWAFIMEKLNSIYSLKLDGYGSINRGGLFKIWDVGKSGFQRRSKVKINGLISLDMYAIATEKLKLSSYKLDSVAREALNESKRDLPYKDIPGYYASGPNTRGIIGEYCIQDSALVGKLFFKYLPHLELSAVARLARITLTKAIYDGQQVRIYTCLLGLASSRGFILPDGGYPATFEYKDVIPDVGDVEEEMDEDESVSPTGTSSGRNVGYKGARVFDPDTGFYIDPVVVLDFASLYPSIIQAHNLCFTTLTLNFETVKRLNPSDYATFTVGGKRLFFVRSNVRESLLGVLLKDWLAMRKAIRARIPGSSSDEAVLLDKQQAAIKVVCNSVYGFTGVAQGFLPCLYVAATVTTIGRQMLLSTRDYIHNNWAAFERFITAFPDIESSVLSQKAYEVKVIYGDTDSVFIRFKGVGVEGIAKIGEKMAHIISTALFCPPIKLECEKTFIKLLLITKKKYIGVIYGGKVLMKGVDLVRKNNCQFINDYARKLVELLLYDDTVSRAAAEASCVSIAEWNRRAMPSGMAGFGRIIADAHRQITSPKLDINKFVMTAELSRPPSAYINRRLAHLTVYYKLVMRQGQIPNVRERIPYVIVAPTDEVEADAKSVALLRGDPLQNTAGKRCGEAKRKLIISDLAEDPIHVTSHGLSLNIDYYFSHLIGTASVTFKALFGNDTKLTERLLKRFIPETRVVNVKMLNRLQAAGFVCIHAPRWDNKMNTEAEITEEEQSHQIMRRVFCIPKAILHQS

ORF28

Uncharacterized protein ORF28

853 amino acids

98.079 kDa

MAEIETRGPEVFSRMPKGGIGAEKLQRLLRRKHGCTGKVPIYLIHPTVNSLLSLDLISHPAKWSPNAQGLDLHLTSMKKHFTAYCLADVLEILKPLTKDFQSSKFNVMEVLYFEEKEDLTKFIEMTFVEEINKAKANVGFDDRIDIIGNMFITAIKYHLALGFTPTIPTEDFYVEMSWKPDPSFNQIEKVMDYYCWMFERAFDRLGLMTMDEIVHDLMITDKNGVRSVSTITTKRDVVPLDFTKTFNFLGTLFIGNVSQLALIIPDEIKLIFAEKESKNLLLERLSKNIVVVSTELTKEASNAITNIMRNDVRTDEDFKEAAKKREESEKRMNKMLENRLKVALNDTSENSDPFDVDKFGKNMLKNVEAELKMSTNIQNLLASNNVTATKTAIDLDDVHNLAIKSTEYVDTMTGHMPSGSYIPGSKKGIQNEKERKQIQKTLQGQKLNENLDIVVKMLKSKITENELATNKITEMMITHEGQVKMIDELKRNIKLLIEKMTLIEKEVKKEKKENEKLLKDMKISSELIANVSQQLHLSEEDRKRLIDLSASMKDCGEDPLPIQQKLDKATTSLVQLFGSYNTKNGDTIAKRNAELKRTRMAYDQVLSAECVRPISTFIGVRTMQEMQRSNVWMIEKWMGDREVNDAIYAKEKTMVTGEEINYTSGETDENIIQENAEISFIDLNPITKERARTMKTFFNRTEVTEPDKIFDRHYMTIQFKLKGDIDLVMGKPLSQKWDMFYNTNFRLKRDIYTKVGNKLQPKLTEESLILYGKEFFRIMGGEIEGMDRSKIERVMNIVTSIEDVVDVSKMGVSETMIMEMFKIPIFMTVNKLYSALRRRTGIDDIASSNILKK

ORF28

Uncharacterized protein ORF28

590 amino acids

64.337 kDa

MSLPGGRGTVKIETRERIWVRRVNGETGVYDTRAGSFETVSCQEFEAAADTVPSVPVFCDRCFGTSLYEVPLTGFGTFVVGTCCIFSPGDPVDDPSIPAHMRKYQQPIEAHQTMVQVAPGTLKYSHQIPMGKVLGYWHVHMEDRVYLNMIGGIDESEDTGKRCVETFTEADIPCALSLGTLDVGLNEVILECSVVVIPARRGCHAKLFTRDTVSDGLEKFCFQSHATLPPTLLASFGSTSESPERKTFYEAHVDALNNYIKLLRTIYSHKGETEIEQYLIEGSKLYSELIGEPSRVLDATMKAAQIAEPQTHTGGADRQRPQRPDGIPYSVPDRFPMTGYPFAPQFCGDPGLVSHYNPFVPPQSFGQGYGPERVGGYYPQPPNPYVLPISYGQQPYPGHPQPHGHHQQRSGGGDLKAELIETLGLAPKTNAVQESLKSFISEILESELKNCGIKRAAGNIERNCDVDEEPPRTKRARPEPKTAVEAIVRAPYGDFDSTALTTKIGQVSDTVEKLNKVIETLLTQSSAQPAPLSTPAQAAPVQPSLPQPVPEPLAPQEPPPPGTSAPTLEASLPQQKPVVSKGAFETLMNL

ORF28

Protein ORF28

102 amino acids

10.861 kDa

MSMTSPSPVTGGMVDGSVLVRMATKPPVIGLITVLFLLVIGACVYCCIRVFLAARLWRATPLGRATVAYQVLRTLGPQAGSHAPPTVGIATQEPYRTIYMPD

ORF28

Putative transmembrane protein ORF28

85 amino acids

9.746 kDa

MKAKQEIKKIKEFDYDAWIESKELKDIFPPRIMLLWWIGILGMLNYNLVQIVPNSGVALLSVSTFIVGCGLCIGFMLGIEQKKNR