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ORF144

Gene
ORF144
Protein
Terminase, large subunit
Organism
Escherichia phage T5
Length
438 amino acids
Function
The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging). Once the capsid is packaged with the DNA, the terminase complex is substituted by the tail.
Similarity
Belongs to the T4likevirus large terminase family.
Mass
49.717 kDa
Sequence
MEVSRPYVNTVDVIDFGIDKRFFRLPVSGILAQEGITPNGPQIAIINALEDPRHRFVTACVSRRVGKSFIAYTLGFLKLLEPNVKVLVVAPNYSLANIGWSQIRGLIKKYGLQTERENAKDKEIELANGSLFKLASAAQADSAVGRSYDFIIFDEAAISDVGGDAFRVQLRPTLDKPNSKALFISTPRGGNWFKEFYAYGFDDTLPNWVSIHGTYRDNPRADLNDIEEARRTVSKNYFRQEYEADFSVFEGQIFDTFNAIDHVKDLKGMRHFFKDDEAFETLLGIDVGYRDPTAVLTIKYHYDTDTYYVLEEYQQAEKTTAQHAAYIQHCIDRYKVDRIFVDSAAAQFRQDLAYEHEIASAPAKKSVLDGLACLQALFQQGKIIVDASCSSLIHALQNYKWDFQEGEEKLSREKPRHDANSHLCDALRYGIYSISRGK

Gene
ORF144
Protein
Uncharacterized 21.8 kDa protein
Organism
Orgyia pseudotsugata multicapsid polyhedrosis virus
Length
197 amino acids
Mass
21.797 kDa
Sequence
MNVYLYQPDGEQDNDVTFYMPHATNGVIVYLFKMGAEAAPDRTRLVSGYEAGRPIGLRLAVGACNDAFVLSCVRAPCVFRELFIHNRYTAPLGLAVVRAGRAAPEAWHVLSVHRRSEAKRTRHIRALRVHSNVGPDQCYPKALISLAGNVPASFLNTLQRCRAHHKDVAAMAMLCPDLRVDDSVVQFDGVQASIKLR

Gene
ORF144
Protein
Uncharacterized protein ORF144
Organism
Acidianus filamentous virus 1 (isolate United States/Yellowstone)
Length
144 amino acids
Mass
16.731 kDa
Sequence
MTIVNILRVDIDQPFDYLDKQFYGNLTLRKLLVWRIFYVSKVFSQHVESLEFRKSLSGNIHVLVTINPGIQRTLVPLAQFLMGDDIMRTFMNLKRKGKGNYLFSYGNTDADRFLAERQIARKQKALNRKKSKTKNGEKNGEGKS