Protein
Tegument protein UL46 homolog
Organism
Varicella-zoster virus (strain Oka vaccine)
Function
Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival. Interacts with and activates PI3KR1 in order to phosphorylate host AKT on its activating residues. Activates the host AP-1 pathway by triggering phosphorylation of host ERK1/2. Participates in host BIM and BAD phosphorylation, leading to apoptosis inhibition.
Similarity
Belongs to the herpesviridae HHV-1 VP11/12 protein family.
Sequence
MFSRFARSFSSDDRTRKSYDGSYQSFNAGERDLPTPTRDWCSISQRITSERVRDGCLIPTPGEALETAVKALSEKTDSLTSPVLQSTERHSVLLGLHHNNVPESLVVSCMSNDVHDGFMQRYMETIQRCLDDLKLSGDGLWWVYENTYWQYLKYTTGAEVPVTSEKVNKKSKSTVLLFSSVVANKPISRHPFKSKVINSDYRGICQELREALGAVQKYMYFMRPDDPTNPSPDTRIRVQEIAAYTATGYGWMLWFLDVVDARVCRHLKLQFRRIRGPRASVIPDDLLRRHLKTGPAVSAGTGVAFILAATTASALTALLRISVLWRKEEWRDGLNGTAAAIVAAVELITLLHHHFQYLINMMLIGYACWGDGGLNDPYILKALRAQGRFLYFAGQLVRTMSTHSWVVLETSTHMWFSRAVAQSILAHGGKPTKYYAQVLAASKRYTPLHLRRISEPSSVSDQPYIRFNRLGSPIGTGIGNLECVCLTGNYLSDDVNASSHVINTEAPLNSIAPDTNRQRTSRVLVRPDTGLDVTVRKNHCLDIGHTDGSPVDPTYPDHYTRIKAEYEGPVRDESNTMFDQRSDLRHIETQASLNDHVYENIPPKEVGFNSSSDLDVDSLNGYTSGDMHTDDDLSPDFIPNDVPVRCKTTVTFRKNTPKSHH