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OKP1

Gene
OKP1
Protein
Inner kinetochore subunit OKP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
406 amino acids
Function
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
Similarity
Belongs to the CENP-Q/OKP1 family.
Mass
47.349 kDa
Sequence
MAADRDNFLQNIENDSINNGQAMDLSPNRSSSESDSSILMNVNDIKTLRLDVAPEAKSTQSKKSLFYENSDDAEEGEIEERTNKEEGQYHHKGSKQLRFEVGKESTGKLQSHLSDGSATSGEGNVRPWEFRKVIQAEYRERLPRNYELKHWKKPSKIMIGSILRLLETNTVSALDSVFEKYEKEMNQMTHGDNNEVKRIYSKKERLLEIILTKIKKKLRQAKFPSRISERDLDIEYIYSKRQFIQNRYSQELQNNERLEAILSREQNLLEETRKLCMNLKTNNKKRLTEKLIQKDLHPVLNKAMEYTYGLESTNGFMHPDGPVTFRNDSHELNLMLNDPIKSTADVRLDKEEVLSLLPSLKEYTKKSKELKETMGQMISDSHEEEIKEVFVPHHESHQDKTEEDIH

Gene
OKP1
Protein
Inner kinetochore subunit OKP1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
383 amino acids
Function
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis (By similarity). Component of the inner kinetochore COMA subcomplex, which connects centromere-associated proteins and the outer kinetochore (PubMed:29046335). COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Through its multiple protein-protein interactions, OKP1 acts as a molecular nexus for inner kinetochore organization (PubMed:29046335).
Similarity
Belongs to the CENP-Q/OKP1 family.
Mass
44.886 kDa
Sequence
MSKRYLDDVLSPDTGTSDSDSSIENLNADNYRIDIVNDNARRDDIDRIQSSNLNHEPPYNLEGVFAIDDDEHGDEMVRKDSDRRQDITEDNDDSFVPDITTPPRERKRVRFGINEKGGDEEFNNVSPWDFKRLIRKFYKEQLPDTYQIRNWKRPSKDMLTNFIDLIENNIELASEEVFKQYHQELNQLYPDSEEQAKLKDSLENKVFDTTYNIKKRLKRTKVPSKIWVDNLNMEYIYAKGESIKKRYKSELDRAEAIERQLIREEEHLKSLQEKGETQAKKRKQVLSKELSELSKTMHPSLSVALSNTFGLIKDDKMSNEIYQQDKIDFNLKLKTDFSKPLISEKEENSLNGLTNAMDNNRELVNEIFGKISALLQPKKNSNE