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Nubp2

Gene
Nubp2
Protein
Cytosolic Fe-S cluster assembly factor NUBP2
Organism
Mus musculus
Length
275 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure (PubMed:23807208).
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
29.518 kDa
Sequence
MEAAAGERAEPGNLAGVRHIILVLSGKGGVGKSTISTELALALRHQGKKVGILDVDLCGPSIPHMLRAQGKAVHQCDNGWVPVFVDQEQSISLMSVGFLLENPDEAVVWRGPKKHALIKQFVSDVAWGQLDYLVVDTPPGTSDEHMATMEALRPYRPLGALVVTTPQAVSIGDVRRELTFCKKTGLQVIGVIENMSGFTCPHCAECTNVFSSGSGEELARLAGVPFLGSVPLDSQLTRSLEEGRDFIQEFPKSTAYSALTSIAQRVVHRMSALCS

Gene
NUBP2
Protein
Cytosolic Fe-S cluster assembly factor NUBP2
Organism
Gallus gallus
Length
272 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
29.359 kDa
Sequence
MEEVVAERSNLGGVRHILLVLSGKGGVGKSTISTELALSLRHSGKKVGILDVDLCGPSIPRMFKVQDNDVHQCDAGWVPVFVDQEKSISLMSIGFLLEKPDDAVVWRGPKKNALIKQFVADVAWGELDFLIVDTPPGTSDEHISTVEALRPYKPLGAILVTTPQAVSVGDVRRELTFCKKTGLRVLGIVENMSGFVCPHCSECTNIFSKGGGEELAKHAGVPFLGSVPLDPQLSQSLEEGRDFIQEFPKSSAFPALTRIAQQILDGALQRSS

Gene
Nubp2
Protein
Cytosolic Fe-S cluster assembly factor NUBP2
Organism
Rattus norvegicus
Length
271 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
28.926 kDa
Sequence
MEAAAEPGNLAGVRHIILVLSGKGGVGKSTISTELALALRHQGKKVGILDVDLCGPSIPHMLHAQGKAVHQCDSGWVPVFVDQEQSISLMSVGFLLENPDEAVVWRGPKKHALIKQFVSDVAWGELDYLVVDTPPGTSDEHMATVEALRPYKPLGALVVTTPQAVSIGDVRRELTFCKKTGLQVIGVIENMSGFACPHCAECTNVFSSGGGEELARLAGVPFLGSVPLDPQLTRSLEEGRDFIQEFPKSTAYSALTSIAHKVLHQMPALCS

Gene
NUBP2
Protein
Cytosolic Fe-S cluster assembly factor NUBP2
Organism
Bos taurus
Length
271 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
28.789 kDa
Sequence
MEAAAEPGNLAGVRHIVLVLSGKGGVGKSTISTELALALRHAGKKVGILDVDLCGPSIPRMLRAQGRAVHQGDSGWVPVFVDREQSISLMSVGFLLEQPDEAVVWRGPKKNALIKQFVSDVAWGQLDYLLVDTPPGTSDEHMAVVDALRPHSPLGALVVTTPQAVSVGDVRRELTFCRKVGLRVIGLVENMSGFVCPHCSECTNVFSKGGGEELARHAGVPFLGSVPLDPELTRSLEDGRDFIQDFPDSPAFPALSSIAQKILSETPAGLS

Gene
NUBP2
Protein
Cytosolic Fe-S cluster assembly factor NUBP2
Organism
Homo sapiens
Length
271 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
28.825 kDa
Sequence
MEAAAEPGNLAGVRHIILVLSGKGGVGKSTISTELALALRHAGKKVGILDVDLCGPSIPRMLGAQGRAVHQCDRGWAPVFLDREQSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDEHMATIEALRPYQPLGALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAGVPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKILDATPACLP

Gene
nubp2
Protein
Cytosolic Fe-S cluster assembly factor nubp2
Organism
Xenopus laevis
Length
270 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
28.954 kDa
Sequence
MEQTQDGGNLSGVHHIILVLSGKGGVGKSTISTEIALALRHAGKKVGILDVDLCGPSIPRMLNAQSKDVHQCDSGWVPVYVDQEKSISLMSIGFLLEKPDDAVVWRGPKKNALIKQFVSDVAWGDLDFLIIDTPPGTSDEHISTVDALRPFNPMGALLVTTPQAVSVGDVRRELTFCKKTGLRVIGIVENMSGYVCPHCTECTNIFSKGGGEELARLSGVPFLGCVPLDPLLSQSLEQGKDLMQEFPNSAAYPAISSITRQILDMASPQS

Gene
nubp2
Protein
Cytosolic Fe-S cluster assembly factor nubp2
Organism
Xenopus tropicalis
Length
270 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
28.91 kDa
Sequence
MERSQDGGNLSGVQHIILVLSGKGGVGKSTISTEIALALRHAGKKVGILDVDLCGPSIPRMLNAQSKDVHQCDSGWVPVYVDQEKSISLMSIGFLLEHPDDAVVWRGPKKNALIKQFASDVAWGDLDFLIVDTPPGTSDEHIATVDALRPFNPMGALLVTTPQAVSVGDVRRELTFCKKTGLRVIGIVENMSGYVCPHCTECTNIFSKGGGEELARLSGVPFLGCVPLDPLLSQSLEQGKDFVQEFPNSAAYPAISSIARQILDMASPRS

Gene
nubp2
Protein
Cytosolic Fe-S cluster assembly factor nubp2
Organism
Danio rerio
Length
268 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
28.618 kDa
Sequence
MDGSGKGNLDQVKHVLLVLSGKGGVGKSTITTELALAFRHAGKKVGILDVDLCGPSIPRMLSVGKPEVHQCDSGWVPVYADPQQQQLALMSIAFLLEDSDEAVIWRGPKKTALIGQFVSDVAWGELDILLVDTPPGTSDEHLAVLENLRKHRVDGAVLVTTPQAVSTGDVRREITFCKKTNLKILGIVENMSGFVCPHCSECSNIFSKGGGEELAKLTGSAFLGSVPLDPLLTESLEEGRDFLQAFPESSTFTAISHIANTLLNSLNA

Gene
nubp2
Protein
Cytosolic Fe-S cluster assembly factor NUBP2 homolog
Organism
Dictyostelium discoideum
Length
265 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Mass
28.962 kDa
Sequence
MDKIKHKILVLSGKGGVGKSTVSSQLALYLSHIGYKVGLLDVDLCGPSIPKMMGLESKDVHKSTKGWVPVYTDESQKLGVISIQFLLGDKDTPVIWRGPKKNSMIKQFIDDVNWGEIDFLIIDTPPGTSDEHISVTEELLKHNPDGAILVTTPQAVSISDVKKEISFCNAMKLPIIGIIENMSGYVCPHCSECTNIFSSEGGKLLAEQCNIKFLGKLPIDPNLSICSERGINYFTEYPNSSTLASLKSFVDNFNFKSSTTTTATN