NUGGC

Gene

NUGGC

Protein

Nuclear GTPase SLIP-GC

Organism

Homo sapiens

Length

796 amino acids

Function

Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).

Mass

91.132 kDa

Sequence

MAETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSMEQSALKEYEKLESRTRRVLSNTYQKLIQSVFLDDSIPNGVKYLINRLLALIEKPTVDPIYIALFGSTGAGKSSLINAIIQQAMFLPVSGESICTSCIVQVSSGCCVQYEAKIHLLSDQEWREELKNLTKLLHRTEELSREEADAWNRDEAVEEATWKLQMIYGNGAESKNYEELLRAKPKRKIPTSRVITLKAEEAEELSIKLDPYIRTQRRDWDGEAAEMRIWPLIKHVEVTLPKSDLIPEGVVLVDIPGTGDFNSKRDEMWKKTIDKCSVIWVISDIERVSGGQAHEDLLNESIKACQRGFCRDVALVVTKMDKLHLPEYLRERKAGNQAIQSQREAVLERNEMIKLQRTRILKEKLKRKLPADFKVLEASDLVYTVSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYVTEAFGLLLLTDSFNSTQNLPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSKGNQGFHQTLKAVCLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALMPHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKRRIYESLTASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTGIVEKVKGSITTMLALASSQGDGLYKELADVGSEYKEMEKLHRSLREVAENARLRKGMQEFLLRASPSKAGPPGTSL

Protein

Nuclear GTPase SLIP-GC: NUGGC

Gene

Nuggc

Protein

Nuclear GTPase SLIP-GC

Organism

Mus musculus

Length

796 amino acids

Function

Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (By similarity). Reduces somatic hypermutation in B-cells which may enhance genome stability (PubMed:22833677).

Mass

91.269 kDa

Sequence

MEEMEALVGVVPHSADCDLFKEPVRKRRRLHRDRQFQAFPSAEQSALKEYEKLECRTRRVLSNTYQKLIQSVFLDDSIPSGLKYLINRLLALIEKSPLEPVYVGFLGITGAGKSSLINALIRQAMFLPVSGESVCTSCIVQVSSGCCEQYEAKIHLLSDQEWKAELKDLTKLLHRAEQSGEEEADLWDRDDATEEAAQKLRMLYGHGAERRHYEELLRLKPRGRIPNSRTITLKAEEAGELSVKLDPYIRTRRRDWDGESAETQIWPLIKYVEVILPKSALIPEGVVLVDIPGTGDFNSKRDKMWKKTIDKCSVIWVISDIERVSGGKTHEDLLSESIKACQRGFCRDIALVVTKTDKLHLQEYLRERKMGNQAIQSQREAVLQRNEIIKLQRKRMLKEKLKRKLPADSKVLEASDLVYTVSAHEYWQRTILTEEESEIPKLREYIRKRILDKKRRLVTKYVTEAFGLLLLTDTLNTEESLLTEELNTGGLRQFVEEKMELLEKAIEQCFARMEQPLQTGVQVAMTSYRRILGSCLVRSRGNQGFHQTLKAVCLKNGVYASRTLARIDLNEALSQPIYDQIDPVFGGIFRDGKPTAPALMQHIDAFKHSLEERMAEVGVRSGWKQDGYKRSFLIQEISAILGGLESHILRRKRKIYKSVTSSIQNDLKPCYEEAAQITGKKACERMKDVIRRGVERQVAEGLFERAQERMWHQFRQLKHGITEKVKGSITTMLTLAAPQGVGLCKELADVRNEQKEMEKLYRSLREVAENAQLRRSMQDFLLRMSPSKAGPHGTKL

Protein

Nuclear GTPase SLIP-GC: Nuggc