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NUDT11

Gene
NUDT11
Protein
Nudix hydrolase 11
Organism
Arabidopsis thaliana
Length
222 amino acids
Function
Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP from CoA and 4'-phosphopantetheine. Can use malonyl-CoA, hexanoyl-CoA, lauroyl-CoA, myristoyl-CoA and palmitoyl-CoA as substrates, but not isobutyryl-CoA or propionyl-CoA.
Similarity
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Mass
25.679 kDa
Sequence
MSSTTTDSTELQNLIKLFQNCQTHPRQHFPAKSSAVLVCLYQEQREDKNELRVILTKRSTTLSSHPGEVALPGGKRDQEDKDDIATALREAREEIGLDPSLVTIISVLEPFVNKKGMSVAPVIGFLHDKKAFKQLPNPAEVEEIFDVPLEMFLKDRNRRAEEREHEGERYLLQYFDYYSEDKERSFIIWALTAGILIRVASIVYQRLPEFQERKPSFWNQPN

Gene
NUDT11
Protein
Diphosphoinositol polyphosphate phosphohydrolase 3-beta
Organism
Bos taurus
Length
164 amino acids
Function
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Similarity
Belongs to the Nudix hydrolase family. DIPP subfamily.
Mass
18.519 kDa
Sequence
MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPGGAAVREVFEEAGVKGKLGRLLGNFEQNQDRKHRTYVYVLTVTEILEDWEDSVSIGRKREWFKVEDAIKVLQCHKPVHAEYLQKLKLGGSPTNGNSVAPSPPEGDP

Gene
NUDT11
Protein
Diphosphoinositol polyphosphate phosphohydrolase 3-beta
Organism
Homo sapiens
Length
164 amino acids
Function
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Similarity
Belongs to the Nudix hydrolase family. DIPP subfamily.
Mass
18.559 kDa
Sequence
MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGVFEQNQDRKHRTYVYVLTVTELLEDWEDSVSIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSPDSDP

Gene
Nudt11
Protein
Diphosphoinositol polyphosphate phosphohydrolase 3-beta
Organism
Mus musculus
Length
164 amino acids
Function
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear.
Similarity
Belongs to the Nudix hydrolase family. DIPP subfamily.
Mass
18.593 kDa
Sequence
MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPDGAAVREVYEEAGVKGKLGRLLGVFEQNQDRKHRTYVFVLTVTELLEDWEDSVSIGRKREWFKIEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSAAPSPPESEP