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NT5C3B

Gene
NT5C3B
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase
Organism
Homo sapiens
Length
300 amino acids
Function
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).
Similarity
Belongs to the pyrimidine 5'-nucleotidase family.
Mass
34.389 kDa
Sequence
MAEEVSTLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSRFAYNGKRCPSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEKLPHMVEWWTKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLQHILCQGVQLEMQGP
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase: NT5C3B

Gene
Nt5c3b
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase
Organism
Mus musculus
Length
300 amino acids
Function
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity).
Similarity
Belongs to the pyrimidine 5'-nucleotidase family.
Mass
34.425 kDa
Sequence
MAEEVSSLMKATVLMRQPGRVQEIVGALRRGGGDRLQVISDFDMTLSRFAYNGQRCPSSHNILDNSKIISEDCRKELTELFHHYYPIEIDPHRTIKEKLPHMVQWWSKAHSLLCQQRIQKVQIAQVVGESTAMLREGYKTFFDTLYQNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFSEDGFLKGFKGQLIHTYNKNSSVCENSSYFQQLQNKTNIILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLRHILYQGDCVELQGS
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase: Nt5c3b

Gene
Nt5c3b
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase
Organism
Rattus norvegicus
Length
300 amino acids
Function
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity).
Similarity
Belongs to the pyrimidine 5'-nucleotidase family.
Mass
34.536 kDa
Sequence
MAEEVSSLMKATVLMRQPGRVQEIVSALRRGGGDRLQVISDFDMTLSRFAYNGQRCPSSHNILDNSKIISEDCRKELTELFHHYYPIEIDPHRTIKEKLPHMVQWWSKAHSLLCQQRIQKFQIAQVVGESTAMLREGYKMFFDTLYHNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFSEDGFLKGFKGQLIHTYNKNSSVCENSSYFQQLRNKTNIILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLQHILRQGDCVELQGS
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase: Nt5c3b

Gene
NT5C3B
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase
Organism
Gallus gallus
Length
289 amino acids
Function
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity).
Similarity
Belongs to the pyrimidine 5'-nucleotidase family.
Mass
33.109 kDa
Sequence
MVPELQKSTVRIQQPERVMGVIRAIKEQGCSKLQVISDFDMTLSRFGCNGRRCPTSHNILDNSHVISEDGKKKLKDLLHHYYPIEIDPNRTLEEKRPLMVEWWTRAHELLSQQKIQKGDIAQIVRESDVMLRDGFNELFDQLHKYSVPMFIFSAGVGDVLEEIIRQANVFYPNVNVVSNYMDFDDSGVLKCFKSPLIHTYNKNNSVLQGTAYFQQLSTRTSIILLGDSMGDLTMADGVPSVENILKIGFLNDKVEEQRGRYLDAYDIVLESDETLDVVNGILRYILMET
Protein
7-methylguanosine phosphate-specific 5'-nucleotidase: NT5C3B