Nrros

Transforming growth factor beta activator LRRC33

693 amino acids

Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (PubMed:29909984). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (PubMed:29909984). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (PubMed:29909984). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable).

Belongs to the LRRC32/LRRC33 family.

77.14 kDa

MEFPPLWLCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCRGLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNLSSKIVRVVELPEGLPQGCKWEQVDTGLFYLVLILPSCLTLLVACTVVFLTFKKPLLQVIKSRCHWSSIY

NRROS

Transforming growth factor beta activator LRRC33

692 amino acids

Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling.

Belongs to the LRRC32/LRRC33 family.

76.52 kDa

MELLPLWLCLGFHFLTVEWRHRSGMVTAASQGGCELLDGVADCRGRNLASVPSDLPPSSRTLLLDANPLRTLGNNSLQRYPFLESLSLHDCYLERIGHVAFQEQARLRSLALPDNALSESYKETAAALHGLRGLRMLDLSGNSLTEDMAALMLQNLSSLESVSLARNIIMRLDESVFEGLGHLRELDLQRNYIFEIEGGAFDGLTQLRHLNLAYNNLPCLVDFSLTQLRSLNVSYNVLEWFLASGGEAAFELETLDLSHNQLLFFPLLPQCSKLHTLLLRDNNMGFYRDLYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFASSDLSSLRFLDMSQNQFQYLPDGFLKKMPSLSHLNLKQNCLVTLHIREHEPPGALVELDLSQNQLSELHLAPGLPGCLRSLQSFNLSSNQLLGVPAGLFANARNLATVDMSHNQISLCPLPASLDPGGTPGCVDFRNVASLQSLSLEDCGLEALQDCSFQGTALTHLDLSGNWGVLNGSIAPLWDVAPTLQVLSLRNVGLTSSFTELDFSAFENLRSLDLSGNALTSFPRFGGSLALQTLDLRRNLLTALPQRAVSEQLAGSLRTIYLSQNPYDCCGVEDWGALQRLHIVADLAMVTCNLSSKVIRLTELPAGVPQVCKWERVDMGLLYLVLILPSCLTLLVACTITFLTFRKPLLQVIKSRCHWSSIY

NRROS

Transforming growth factor beta activator LRRC33

692 amino acids

Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260).

Belongs to the LRRC32/LRRC33 family.

76.366 kDa

MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSCLTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY

Nrros

Transforming growth factor beta activator LRRC33

692 amino acids

Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling.

Belongs to the LRRC32/LRRC33 family.

77.07 kDa

MEFLPLWLCLGFHFLIVEWRSGRGTATAASQGGCKVVDRVADCRSLNLASVPSGLPAHSRMLVLDANPLRVLWNHSLQAYPRLEDLSLHSCHLDRISHWAFHEQGHLQNLVLADNRLSENYKESATALHTLLRLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSVFEGLERLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEAAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNSMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVSLWEEFSSSDLSALRFLDMSQNQLRHLPDGFLKKTPSLSHLNLNQNCLTKLHIREHEPPGALTELDLSRNQLAELHLAPGLTGSLKNLRVFNLSSNQLLGVPTGLFHSASSITTLDMSHNQISLCPQTVPLDWEEPSSCVDFRNMASLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGILNGSVSPLSAVAPTLQVLSLRNVGLGSGAAEMDFSGFGNLRELDLSGNSLTSFPKFKGSSALQTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQHFKTIADLSMVTCNLSSKIIRVVELPEGIPQDCKWGQVDTGLFYLVLILPSCLTLLVASTVIFLTFKKPLLQVIKSRCHWSSIY

nrros

Transforming growth factor beta activator LRRC33

685 amino acids

Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by lrrc33/nrros is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by lrrc33/nrros.

Belongs to the LRRC32/LRRC33 family.

77.765 kDa

MPVCGCLSVVLSHAVVLLMLVLHSASGHPQTFPCRLIQRVALCSGRQLSVIPDCLPHETEEIFFDRNLLENLQDGLSRYPFLRMFSCANNQLMTVAETAFIESHLLENLNLANNELHHGHKQVAQAFRSLTQLKTLDLSGNGLSEDMVSVLVANLSSLESLYLSRNGMQRLDESTFRDLHQLKELNVERNLLFEISGAFDHMKKLQRLNLAFNCLPCLVNFEMTQLLVLNASHNSIEWFITNQNLTETFQLETLDLSDNHLLFFPFLPTNNQIRTLLLSNNRVGFYQHLANSTSSNWTTSVDYYNLGQNISNITMDLWNENLHGNLSSVEFLDLSENKVNYFPQGFIKQMPQLYWLKLRSNCLQSFSLTSEDLPVTIYELDVSRNRLTEIKASQTSKNKLNNLTHLNLSTNDLQNFPPMIFTSLPNLNTLDLSHNTVDVCYSSNYMGLSGCVEWSSMASLKQLYLADCSIQNVPSSAFKGTSLTHLELSNNPNLHLKQQSLKGLANTLQHLGIGNTGLQDFDFSPYTNLKSLNISRNSLSKLPDSLMALNLKLLDLRDNSLTTIKSEHASLLAKKLQTVYMNGNAFNCCHLDWFRTFGENKGIHVADLSEITCLDLNYRRHKVVLTDAVYCGFTNNNKESVVWYILLFVTVSVSIMGISVIYMLTFKPRMLPRVIKKKCWRPTSY