Protein
Nonribosomal peptide synthetase 1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Function
Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence. Contributes to improved fungal tolerance against oxidative stress, during the infection process.
Similarity
Belongs to the NRP synthase family.
Sequence
MAQSTVSCYLPNFGATCDGPKRPLSLKLRTDALQSSGLLSAWREGQLTQLLQASWALILHRYTGSEDICFGYHQIGNVSQDLLQSLEAVDPALCKVSVKEGISLKMFFDQFKTHNSPDSPLEIDRSSRKASENARLYNTILMIQICHDSNGTSPAIPLPSSLPIALPQEVSTERLVLYLPVQPSETYLQSRVRLHVKVLQDEVNIFFEWWNNDMPTAQMKSIAGAFGHILTDLLAANDTAVDDLDIFPENDWSRVCSFNSVLPKKHERCIHEMIYDRTLLQPENEAVCSWDGSLTYKELDLLSSKVAYDLQQRGVGPEVCVALCFEKSKWYTVAMLAVLKAGGAFVPMDPSHPTARLQSLVEGVQAHIMLCSRSQTGKLQTVAETLIPLDEETVDGLPDLPTSTFSSTTVKSSNAAYVIFTSGSTGQPKGTLLEHRAYVSGALAHGPVFGLNSSTRVLQFASHAFDASLVDILSSLIFGSCICIPSEEARLNDIAGVINEMKVNHASLTPSFVGFLDPAAVPGLESLVLAGEAMSPQHLATWSHIKLVNGYGPTESSVAAALNPNMSSSSDCRDIGLPVGVRFWVVNPANHDQLVPVGCPGELVLEGPTLARCYINNPQKTSDSFIFNPCWTKRDPNGGSDRRFYKTGDLVRYNSESGSLTYIGRKDAQVKFHGQRVELGEIESQLSADTDIKHCTVLLPKSGFAQGKLVTVVSLSAGPGQALEADAVPLKLIEHREKLRYVKSIQERLSIRLPTYMVPGVWLCVEALPMLVSGKLDRKSIATWVASMSEDPEVHATEAANARAANSTEDQLVSIWSRVLNVPKDRISVDESFLSLGGDSIAAITCVGHCKKQGIGLTVQEILRSKSIRELATRVKGVTQPVAYHEMIEEPFGLSPIQKLHFMVRKEGQGYFNQSVVTRIDRQINDQDMRRAVEAVVMRHSMLRSRLVDPSTGNSLQLRITEDVAGSYRWRTHYMTAQNEIENAIAESQLCINAFVGPVFAVDFCYVDEDSHNLLSLVAHHLVVDIVSWRIILEDLEDFLLNPQGFVLQNSSLPFQTWCRLQDEQCESVAFENDVQLEDLPAPDLAYWGMEHRQMTYGDVICETFELDPGSTQSILLECHQSLRTEPVDLFLAALVHSFGQTFPERTLPVIYNEGHGREVWDSSLDISRTVGWFTTLYPIFVQEIVSEDPARTVARVKDLRRQVSDNGRQKFASRMFTGKGQQTCRHHYPLEMTFNYVGQHRDLQKQDGLFQLMGHMAGEAGQGGGAADFGEETPRFALLEISALVVQGQLRFTFSFNRFMRHQSGIHAWISRCHQLLASLGQKLQSLAPQPTLSDFPMLSLTYEELDKMVSAKLPIAGITSLDLVEDVYPCSRMQQGILLSQSRNTSVYAVHDTFEVKGVGIKPSVDRLIIAWQKVVSRHAMLRTVFLENLTSQDLFCQVVLKEYNPAPALLSCSEERDVLPTFDNQQPVNYRDPRPAHRFSICETANGKLFCRLEISHAAMDGTSISLIVRDLQSAYSGQLQEDRKPMFKDYMRYLQSCSHSAGLNYWLPYLSDVKPCHFPVLNDGRPSNKRLQVIRLDFSSLKELQALCESCGLTLSTAFSTAWGLTLRSFCGSNEVCFSYMASLRDVSVDEIGSVVGPVINLLACRMKVTEDVCLEDVLHQVQNDYMESLPYRHTSLIDIQHALKLSDTILLNSGISYRKLPPKTLSNRDEMRLVEVGKIHDPAEFPVYVNIEATDDVAYIDLNYWTTSLSEGQAQNVASTFLQSLENIIHHHDEKICRLDQLSAQNKQQIAVWNNTLPKAVEKCIHEILEDKVKQCPEAVAIAAWDGNLTYAKLNELSSLLAFYLTKLGVGPGLLVPIDLDKSSWQIVAILAVLRAGGICLPVDAAQPYEFIEKLLIDKDIQVALASPNKAQLLERTIPYVVPVGRSLFDYLPRFDDMPHVSHKAMDHAYVVFTGGSVKEPKGVMLQHLTVLTRAENFASALELNKATKVYQSATYTSDMFLNVLFGTMMRGGCVCIPANDGFNNLPRSINASRANTVVMTPSLASLLQPSEVPEVQLLALYGEILTNQVRTIWSEKVRTHSLYGAAECSSSCIHASDCQTLGETRNLGLAAGCITWLVNLSDHDLLVPIGSVGEVVIEGPVIASGYLLHNGHVKGGFIENPVWRMNFERDEPSNDLEKRDESSTLTRRMFKTGDLARYNSDGILVYMGRKERQTQRLQADIWDVQQCIDTFSLPGHPCVVEPIRCLDDDESVEHLAVFVQFASTHLEKADGQRSVIGQPSSQFFDSVTKMHTYLLSVLPVTQVPRLYIPVPSMPLTSTGLLDRWFLRNEAQNLPAQTRIEFDLKSFHDFWRVELAHPKPSPSQLLPSSTSATHRSSGTSTYEWNGHIEWRDISKLESASLEAALLAAWALTISGYTRSDDVIFGELLLEQDSSGLDSTSDKAAPVVVPRRLQIAEDMSIAELMRKTQERLVAASPFQRAGLQRIRNVSADTSRACSFNNLFCFTRFDCKVQTLALAYPLGIFCIVANSELQLSACYDEQILSAPQVERILVQFARYVEYLKADLRSQETIGDMALRKNQTSYLSSPETVYWRKYLADVESCVFPSLNPDGERSGFSSAKLAIENLADLRRLCQKIEVTEDIVLQLVWGLVLRCYTGSEEVCYGYYQASPQPEGSKYLKVLPSRFLLKDDSDLESIAQQRKSELDEAMEHPISQIELQLELGFDWYSLLNTVFKFDRFAELPNDNNSTLDLLNDTEKGIWTIVVNPRFSFVSADILFEYRTDALSEANITSVVDCFQHILEEIINNDPVGHKIGDINFFGERACQQVREWNAALPERPDRCAHEIIEQQVLSHPTSPAICSWDGEFTYEQLDRLSTKLAKHLVCLGVKPEIFVGLCFEKSAWAVIAQVAVLKAGGAFASLDPSHPDARLRGLVDDIGAHIFLCSAKYLDKARQISRAAYIVSEETLAELPDVSSTASMTRPSIHNAAYAIFTSGTTGKPKVTVLEHIALSVSSPAFARSMGMDTTTRALQFSSYTFDVSIKEIIIVLMTGGCVCVPSDEERMNDLSGAIRRLNANFISCPPSVSNTIQPESVPSVKTVVMGGEKMTASHIDRWGDRFVINAYGPSESTVMATMSVKVDEAGVRVNNDCNSIGAAICGRTWVVDPNNYQRLLPIGAVGELVLEGCNVARGYLNNDQKTKESFISDPAWTKAPGLKELFKRKERMYRTGDLVRYNPDGTICFISRKDTQIKFNGQRIELEEIEQQCISFLSGGTQVAVEVVEPESKAVARSIAAFFTVDNQSGQDRPDLESQLLVPMSEATREKVQKLREALIKALPPIMIPRLFFPVSHLPFSNSGKLDRKKLRATVETLPKDQLKSYATLTAGSRQASDEGVEGTLRSLWEEALGLASGSVSAEDSFFSLGGDSFSAMKLVGAANSQGISLTFADVYEDPVFMNMAKRCGMLQGRSGRQTVTPFSLLPASVDREQLLEEVAEQCGVPRASIVDLYPCSPVQEGLLTLSVKQNGAYIAQPIFRLSEGIDLDMFKAAWQQVVDELDILRTRIVHTESLNFLQAVIDKEEISWASATTLDELTAESPELPRHNGGRLTGYAIAASQTGRYFCWTIHHALYDGWSIPLVLRRVEEVYTNSTASARTVPYSLFINYLLERSMADSDEYWKSQLANLSCSPFPQSRNPLPDSVRVGNRHHSSMKISRAASGVDLTIPELIRAAWAIVVSAHTGSSDVCFGETLMGRNIDLAGVTDIAGPVLTTVPTRIQVDNELPITQYLENMHHLTTTMLPHQHSGLQQIRKLNSDTASACEFQNLLVIQTGEGQLNKALWVAEPIQTSGDFFTHPLVVECKVDTSEVSITMHHDEIVLNSWQTEKLIGQFSFVLEQLLSINKGETRKLSELEIFSPLDSKEVALWNKRHPEAVEKCAHDIISERCSTHPDAPAVCAWDGEVSYKEMYTLASSFASYLACRGVGPETLVPICLDKSLWAIITILGILIAGGAYVPLDPAHPTSRHEEILTEVDARILICSPQYQSRYSSIVKTIIPVSKETIRAYFALNYQAKGLRRVTPFNMAYAIFTSGSTGRAKGIIIDHRALASSAMAFGPIVHLNETSRAFQFASLTFDAAVMEILATLMHGGCICIPSEDERLNDVAGAIRRMNVTWTFLTPSIASIIEPSTVPSLEVLACGGEKLSREVVTKWAHRVKLINGYGPTETTIFAVLNNVSPTTDPACIGYGIPCTLTWVVDPENHDRLTPLGAIGELALEGPALAREYLKNPKKTAEAFVDEPAWMKHFQSTLPSPRRIYKTGDLVRYNPDGSVEYISRKDYQVKLHGQRMELGEIEHRLHEDDRVRHAIVILPKEGLLKGRLVTILSLNSLKSGSSIISDNACELISREDLARVAYSELITIQKNLEAQLPIYMVPQTWAVIKKLPMLVSGKLDRKKITHWIENIDEPTYDRIMQDYDNIKRGHVEDSVNEDKSTAAKILQDIYAQVLNLPSNKVDPKRSFVSLGGDSITGMAVISRARKQGLNLTLHKILQSKSIVELIQAAEVETSSIQVEEKANKYFSLSPIQNLYFKSARTFKETGRFNQGMTVRVTRKVEPNVVKDALKAVASQHSMLRARFSRSANGKWQQRITNDIESSVRVGIHSVMSSHEMLGKIANTQSSLDIENGPIIAADLFTVNGEQVLFLVANHLCVDMVSWRIILQDIQEVIEAGSLSSEKPFSFQSWCELQLENSRSEADKAKLPFAIEPPNLSYWGMESVPNHYGQIRMESFVVGEDTTSFILGDCHEMLRTETIDILLAAVAQSFRRVFTDRRMPTIYNEGHGRESWDSNLDLSRTVGWFTTLCPLQVDECSGSDFVDTTKRVKDLRRKIKDNGRSYFARSLLQANNTEPSDFPVPLEIVFNYLGRLQQLERDDSLFKHYGEAFDEEKFRLAGDMGSDTPRFALLEISALVVNDKLQVSFTYNRQMQRESQIFQWISECRRVLEIDVLRFKDTVPEPTLSDFPLLPITYDGLKKLTSTTLPRAGVKTFSQVEDIYPCSSVQEGILLSQLRDPSAYMFHVIFEVRSPGGSGKVDPNMLRSAWSAVINRHPILRTLFIDSNYANGTFDQLVLRKVDEGAIILHCNDSDALVKLDTIKLSEINAGRCPKLLHQLTVCSTDSGRVLIKLEMNHAIIDGGSVDLLLRDLAMAYKHQLPEGSGPHFSDYIKFVRGKSQSQALSHWRQYLSDAHPCHLTFSEGTGGSRQLGSVMVPFSRYSELQQFCEKNSVTLANLTLAAWAIVLQSFTGSNDVCFGYPSAGRDAPVPGIQDAVGIFLNMLCCRVRFSPGKTLLEVSKTVQDDYIKNLPYQDCSLASIQHELGQKELFNTTISIQNHHAVSEESGNDLLSFDVQTAHDPTEYPVTVNVETAKGHEGILLRYWTDAVPEDKANNLANAIAHIFSCFIDKPSQLVSELDLRGGQLMKGGQFIDSKSLQELIDRRVTEIISQMLKEGTLAIPAADNGKGQFKGTTRAQPAKVTIKARGMHRERDLSDSTATLTEDHSKLMEPEKRLWKIWCSALGLASDTIQRQASFFKLGGDSITAMKMVSAAREDGLTLTMADVFNNPVFEDMLAAISASNSSSALEPDSPADSNNEKPAEPPRLVELERNPPPPEISLLKTVPLNDSALQDGICPKIGVFKGGIADVLPVTDFQAMSITATLFKSRWMLNYFFFDGRGSLDLRRLRESLLRVVDAFDILRTVFVCFNGQFFQVVLRKIRPNIFVHETEKNLDEYTEYLQQQDREQEARQGEQYVKFYIVKKKGSNHHRILIRMSHAQFDGLCLPTIMSAIKLGYEGSTLPPAPSFANYMRMLSGAITPDHYQHWTNLLKGSKMTQVIRRTEENTYRYIGAFREQRKTLEIQPSVLENVTIATVMQAAWAVTLAKLSAQSDVVFGLTISGRNTSIPGIENTVGPCLNVIPIRVTFKEGWTGVDLFRYLQDQQIANMPFEALGFREIIRRCTDWPSSTYFTTSVFHQNVEYEGQMQLDNTTYRMGGAGVVDNFTDMTLFSKSSSDGKLGVSLGYSDKGPIGPKFAAKVLSMVCDTVQSLLANSRVGLPSPSMLRSLPCQSVHDVPGMTDEMFLSTHLKDRSISDILVHSDVVTQAWQQVLPRNNADEPQSSFQLDSSFFELGGDVFDMAQVVWLLEQEGLQVHIEDLLEHPTFLGQMAVLTLHNSRTSDSMEEIVPVEEIPLPAARTGTSSSLGKALTLAKKVTRWSALSARG