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NR4A1

Gene
Nr4a1
Protein
Nuclear receptor subfamily 4 group A member 1
Organism
Mus musculus
Length
601 amino acids
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (PubMed:22427340).
Similarity
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Mass
64.738 kDa
Sequence
MPCIQAQYGTPATSPGPRDHLTGDPLALEFGKPTMDLASPETAPAAPATLPSFSTFMDGYTGEFDTFLYQLPGTTQPCSSACSSASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSEYYGSPCSAPSPSTPNFQPSQLSPWDGSFGHFSPSQTYEGLWAWTEQLPKASSGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPPPATHQLGEGESYSMPAAFPGLAPTSPNRDTSGILDAPVTSTKSRSGASGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPSTAKLDYSKFQELVLPRFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELCPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHQLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMATVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF

Gene
NR4A1
Protein
Nuclear receptor subfamily 4 group A member 1
Organism
Bos taurus
Length
598 amino acids
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Mass
64.437 kDa
Sequence
MPCIQAQYGTPAPSPGPRDHLAGDLLTPELSKPTMDLASPEAAPAVPTALPSFSTFMDGYTGEFDTFLYQLSGTAQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGPFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPPGPSPSLAPSPLKLFPSQAAHQLGEGESYSMQTAFPGLVPTSPHLDGSGRLDAPVTSAKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPETSPAHLLTSLVRAHLDSGPSTSKLDYSKFQELALPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPGDQDLLLESAFLELFILRLAYRSKPAEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLVVDIPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVSAEAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF

Gene
NR4A1
Protein
Nuclear receptor subfamily 4 group A member 1
Organism
Canis lupus familiaris
Length
598 amino acids
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Mass
64.424 kDa
Sequence
MPCIQAQYGTPAPSPGPRDHLASDPLTPELSKPTMDLASPEAAPTAPTALPSFSTFMDGYTGEFDTFLYQLPGTAQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPLDETLSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGPFSPSQTYEGLRAWTEQLPKASGHPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATCQLGERESYSISTAFPGLAPTSPHLDGPGMLDAPVPSAKARSGAPSGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPGDQDLLLESAFLELFILRLAYRSKPAEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHGLVVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVSAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF

Gene
NR4A1
Protein
Nuclear receptor subfamily 4 group A member 1
Organism
Homo sapiens
Length
598 amino acids
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Mass
64.463 kDa
Sequence
MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF

Gene
Nr4a1
Protein
Nuclear receptor subfamily 4 group A member 1
Organism
Rattus norvegicus
Length
597 amino acids
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (By similarity).
Similarity
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Mass
64.282 kDa
Sequence
MPCIQAQYGTPATSPGPRDHLTGDPLALEFSKPTMDLASPETAPTAPATLPSFSTFMDGGYTGEFDTFLYQLPGTAQPCSSASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSDYYGSPCSAPSPPTPNFQPSQLSPWDGSFGHFSPSQTYEGLRVWTEQLPKASGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPAPATHQLGEGESYSVPAAFPGLAPTSPNCDTSGILDAPVTSTKARSGSSGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPNTAKLDYSKFQELVLPRFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELSPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMAAVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF

Gene
nr4a1
Protein
Nuclear receptor subfamily 4 group A member 1
Organism
Xenopus laevis
Length
577 amino acids
Function
Probable nuclear receptor.
Similarity
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Mass
64.383 kDa
Sequence
MPCIQAQHGSLSQCAGPCDNYVPDILNSEFGKFTMDLVNSEIAASTSLPSFSTFMDGYTGEFDAFLYQIPSSNQQSSLKVEEFQVFGCYPGSFTNQLDETMSSSGSDYYGSPCSIPSPSTPGFQNPQLPTWECSYGAYSPTQNYDNMRHWTEQQKNSISQQTFFSFGTPAHSPNMAANPLKIAPATHRLDQQLVDTDVFALAQNSSAGFPAVPLGQAPGVLDSSVLLDSPLSPSKTRSPSSNEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKQIAESSPVDLINSLVRAHIDSIPSSSKLDYSKFQETVPLQLEKESSVDVQQFYDLLSGSLEVIRKWAEKIQGFVDLPKEDQDLLLESAFLELFILRLAYRSRPEEGKLIFCNGVVLHRTQCVRGFGEWIDSIIEFSHSLQRMNIDVPSFSCLSALVIVTDRHGLKEPKKVEELQSQIINCLKEHIPSSMNEQNRPNCLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIVDKIFMDTLPF