NIC1

Gene

nic1

Protein

High-affinity nickel transport protein nic1

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

408 amino acids

Function

High-affinity nickel transporter responsible for nickel uptake. Required for urease biosynthesis.

Similarity

Belongs to the NiCoT transporter (TC 2.A.52) family.

Mass

45.627 kDa

Sequence

MNSMSEYVKPRKNEFLRKFENFYFEIPFLSKLPPKVSVPIFSLISVNIVVWIVAAIVISLVNRSLFLSVLLSWTLGLRHALDADHITAIDNLTRRLLSTDKPMSTVGTWFSIGHSTVVLITCIVVAATSSKFADRWNNFQTIGGIIGTSVSMGLLLLLAIGNTVLLVRLSYWLWMYRKSGVTKDEGVTGFLARKMQRLFRLVDSPWKIYVLGFVFGLGFDTSTEVSLLGIATLQALKGTSIWAILLFPIVFLVGMCLVDTTDGALMYYAYSYSSGETNPYFSRLYYSIILTFVSVIAAFTIGIIQMLMLIISVHPMESTFWNGLNRLSDNYEIVGGCICGAFVLAGLFGISMHNYFKKKFTPPVQVGNDREDEVLEKNKELENVSKNSISVQISESEKVSYDTVDSKV

Protein

High-affinity nickel transport protein nic1: nic1

Gene

NIC1

Protein

Nicotinamidase 1

Organism

Arabidopsis thaliana

Length

244 amino acids

Function

Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Prevents the accumulation of intracellular nicotinamide, a known inhibitor of poly(ADP-ribose) polymerases (PARP enzymes).

Similarity

Belongs to the isochorismatase family.

Mass

27.023 kDa

Sequence

MANHETIFDQLKKQIPVDEEEPLILNRDSSVGLVIVDVVNGFCTIGSGNMAPTKHNEQISKMVEESAKLAREFCDRKWPVLAFIDSHHPDIPERPYPPHCIIGTEESELVPALKWLESEDCATLRRKDCINGFVGSMESDGSNVFVDWVKEKQIKVIVVVGICTDICVFDFVATALSARNHGVLSPVEDVVVYSRGCATFDLPLHVAKDIKGAQAHPQELMHHVGLYMAKGRGAQVVSKISFET

Protein

Nicotinamidase 1: NIC1