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NFIA_089900

Gene
NFIA_089900
Protein
Eukaryotic translation initiation factor 3 subunit D
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
585 amino acids
Function
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
Similarity
Belongs to the eIF-3 subunit D family.
Mass
65.183 kDa
Sequence
MAPMSIADLVAALPAEDTWGPATPSDNMLDGVPYAPFSKGDKLGRMADWTGDGKDRDRGGRQAYNRNYRDQQVYGAGTSSLFNIQVAEDESSFSVVDNTRTSTKRTFARGGGTVFRGRGQRGVGQRGGRAGFQRVGAGRGQGGDRYYDNRSARGNRGRRFGWKDYDKPQRTREPSVNVRPDWTMLEEVDFNRLSKLNLEAPEGEDLDSYGFLYYYDRSYDKAPVKNAERKLQALERAAYNVTTSQDPVIQELAEKNEATVFATSDILSMLMCAPRSVYSWDIVIVHQGDKIYFDKREGASIDLVTVNENAADAPMETTDSSGKQESINTPSALALEATFINHNFALQTVVESEESKVTFSHPNPFYNAAEETEPLASKGYKYRRFDLSLQGDEEPLNMIVRTEVDAVMKNPVGGEDQQLIVKALNEFDSKAPGSGGALDWRSKLWSQRGAVVATEMKNNSIKLARWTTQAILAKADAMKLGFISRANPRSATSHVILGVVGYKPREFAAQMNLNLGNGWGIVRTIVDRIRSLDAEEEEDKVKKYVLIKDPNRPVIRLYSVPPNTFEEDDEAAEEQEEKAEEESEE