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NFIA_086780

Gene
NFIA_086780
Protein
Very-long-chain 3-oxoacyl-CoA reductase
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
345 amino acids
Function
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
37.296 kDa
Sequence
MEFLSKYTACLSNWGLNLEPGLQTVGAAVLLTTGSLFIASRVLTFVRVLLSLFVLPGKPLRSFGPKGSWAVVTGASDGLGKEFSLQLARAGFNIVLVSRTASKLTTLAEEITTKHSVQTKTLAMDFAANDDADYEELKAIVNGLDVAVLINNVGKSHDIPTPFALTPEDEMTDIVTINCLGTLRTTQLIIPGMMQRKRGLVLTMGSFGGLLPTPLLATYSGSKAFLQQWSTSLGSELEPYGITVELVQAYLITSAMSKVRRTSATIPDPRAFVKAVLSKIGRNGGSPGYAYSSSPYWSHGLMAWFLTCVMQPMGKLVVGQNKSMHEAIRKRALRKAEREKGKKST