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NFH1

Gene
NFH1
Protein
Nod factor hydrolase protein 1
Organism
Medicago truncatula
Length
385 amino acids
Function
Symbiotic enzyme that hydrolytically inactivates Nod factors (NFs) with a C16:2 acyl chain produced by the microsymbiont Sinorhizobium meliloti (PubMed:27383628, PubMed:29367305). NFs are lipo-chitooligosaccharide signaling molecules produced by nitrogen-fixing rhizobia to initiate nodulation (symbiosis) on the roots of legumes (PubMed:27383628, PubMed:29367305). Controls NF hydrolysis at the stage of root hair infection (PubMed:29367305). Involved in the regulation of growth and branching of mature nodules (PubMed:29367305). Modulates NF levels and signaling to complete transition of infected nodules to functional nitrogen-fixing organs (PubMed:29367305). Lacks chitinase activity in vitro toward glycol chitin, carboxymethyl-chitin, colloidal chitin, and the chitin oligosaccharides (N-acetylglucosamine) (GlcNAc)6 and (GlcNAc)5 (PubMed:27383628).
Similarity
Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
Mass
42.193 kDa
Sequence
MANFLKLKQFLTLVLILLALAAKSSKSTPSPSSTTRVKGIYWIENPLFPPSSIDTSLFTHIFYAFVSPNKFTYKLEEEEEDSTTVATSLTTFTNTFKTKTPPIPTLLSIGGATSNSTLFAFIASDPTARATFINSTIQVARTFGFDGIDFDWEFPTTTKEMNDLGELLFQWRRAISDETASTSRPPLLLTAAVYFAVNFFLSGERRMYPVDSINKNLDWVNVMSYDLRGSGSNVTGAPSGMFDSKSNVSVVSGLFSWIRGGVAPEKIVMGMPLYGKSWKLQDPNVHGIGAPNVGPGPGVDGGMAYFQVVDFNKQMGAKVVYDKETGSVYSYSGSTWIGYDDPFTVSVKVGFAQALKLGGYFFWAAGYDTSDWKVSTASKAWRPES