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NFE2

Gene
NFE2
Protein
Transcription factor NF-E2 45 kDa subunit
Organism
Bos taurus
Length
374 amino acids
Function
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).
Similarity
Belongs to the bZIP family. CNC subfamily.
Mass
41.39 kDa
Sequence
MSPCPPQQSRNRVTQLPIPEPGEMELTWQEIMSITELQGLNAPSEPSFEPPAPVPYPGPPPPPSYCPCSIHSEPGFPLPAPPYELPAPTSHVPDPPYSYGSNMTVPVSKPLTLSGLLSDPLPDPLALLDIGLSAGPSKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLTHPNYALPPAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTDLYRDIFQHLRDEAGNSYSPEDYALHQAADGAIFLVPRGTKMEATD

Gene
NFE2
Protein
Transcription factor NF-E2 45 kDa subunit
Organism
Homo sapiens
Length
373 amino acids
Function
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Similarity
Belongs to the bZIP family. CNC subfamily.
Mass
41.473 kDa
Sequence
MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEPQAPAPYLGPPPPTTYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLAHSNYTLPAAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLLRARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTIFLVPRGTKMEATD

Gene
Nfe2
Protein
Transcription factor NF-E2 45 kDa subunit
Organism
Mus musculus
Length
373 amino acids
Function
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Similarity
Belongs to the bZIP family. CNC subfamily.
Mass
41.565 kDa
Sequence
MPPCPPQQNRNRLSQLPVGELGEMELTWQEIMSITELQGLNVPSETSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFSLPPPSYELPASTPHVPELPYSYGNVAIPVSKPLTLSGLLNEPLPDHLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLELEGMEAGRRRSEYVDMYPVEYPYSLMPNSLAHPNYTLPPTETPLALESSSGPVRAKPAVRGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLSSERERLLRARGEADRTLEVMRQQLAELYHDIFQHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD

Gene
Nfe2
Protein
Transcription factor NF-E2 45 kDa subunit
Organism
Rattus norvegicus
Length
373 amino acids
Function
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).
Similarity
Belongs to the bZIP family. CNC subfamily.
Mass
41.496 kDa
Sequence
MPPCPPQPNRNRLPQLPTGELGEMELTWQEIMSITELQGLNVPSEPSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFTLPPPPYELPASTPHAPDLPYSYGNIAIPVSKPLTLSGLLNEPLPDPLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVDMYPVEYPYSLMPNSLAHPNYTLPPTETPLVLESSSGPVRAKPAVRGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTELYHDIFQHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD

Gene
nfe2
Protein
Protein nfe2
Organism
Rhizobium meliloti
Length
311 amino acids
Function
Responsible for the nodulation efficiency and competitive ability of strain GR4 on alfalfa roots.
Mass
34.324 kDa
Sequence
MTDLIGFYSDHKIAAPLAIAQRSAKFKPFAAEIARRGILQIATCARLEFYGEKSVLEDIDGKPFFGFSYGRVEGAISIAERLATIAAGVHSQILGEGFISGQLMQAIESGDPNLSIFKVARVAVDLGSAARKRQEFFAEFDYVQIVEDIIADRFSDKAPLDRIYIIGAGMLGQELIRGNVGERFRSTVVITRNPKKLRKRLNTGPKTNVTFMRPSEVGRTREPGSMVVIATTDVDNKYKAILQETLLRLGPRIILDLSSIPVLTREAIGELDYVNMYGDEFLRFIEQNNQRLAPKLPLVVSDIKAALGAAV