NEDD1

Protein NEDD1

782 amino acids

Regulates microtubules organization in a centrosome-independent manner. Required for the spindle to be positioned correctly and for the function of gamma-tubulin in organizing phragmoplast microtubules (PubMed:19383896). Component of active gamma-tubulin ring complexes (gamma-TuRCs) associated with cortical microtubules in interphase cells (PubMed:25438942). Mediates gamma-TuRC recruitment to the nucleation sites and is important for determining the ratio of branched to parallel nucleation (PubMed:25438942). May mediate the localization of GCP2 and GCP3 to the nuclear envelope (PubMed:19383896).

84.757 kDa

MMSNLVEPSWRLLAASGGDTVKLFDVSADSGDPCVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSLGTVPVTGKDGGDSAEECLSAISFSKKGSRYICSGGTGQIVKIWDLQRKLCIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATELKDPNGQVLRLLDYSRSSRHLLVTAGDDGTVHLWDTTGRSPKMSWLKQHSAPTAGVCFSPSNEKIIASVGMDKKLYTYDSGSRRSSSCIAYEAPFSSLAFGDNGYILVAGTSNGRVVFYDIRGKPQPVTVLHAFSNSEDVTSLSWQTSKPVIVNEKNYTSEMALLGSTVEDSVVIPDPLPSTTPSASQSAMAPGSRGVSASTVNASSVEQTPNRNHLWPSGPLGRLHALRANDSYNDDMGVFSPIIDVSSVEKWADSEGYNNKDHLVVDNKPSSLLFPSSSKGYSFGDNGSKEHPIFDWKPSSTSKQDDPRAAFSSFGSITPTASSKSEDSALTPPEAWGGDKFSEKFNQLANEKFSDKFSHLHAPSRLAVSSTGASTSGSMFSSSRDFPLSHGQTNFANASLEFPRIRDFSSTFETSSTQTDNNLPSSPLFTKGITAPGNIDSLRLSPNFTRRFSTYAERISTTSSFSDGASLSLGGSPKIKKTGSETREEVLNHLLARPETVVATEAGAMPLMNQGGLKQSQTDQQQVMGSSNFTLQLFQRTLEGTLDSFQNSIHDDVRNLHIEILRQFHMHEMEMSKVLSSILENQAEQMKELKLLRKENQELRQRL

NEDD1

Protein NEDD1

660 amino acids

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

71.966 kDa

MQENLRFASSGDDIKIWDASSMTLVDKFNPHTSPHGISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSVHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSSLNKGCSNKPTTVNKRSVNVNAASGGVQNSGIVREAPATSIATVLPQPMTSAMGKGTVAVQEKAGLPRSINTDTLSKETDSGKNQDFSSFDDTGKSSLGDMFSPIRDDAVVNKGSDESIGKGDGFDFLPQLNSVFPPRKNPVTSSTSVLHSSPLNVFMGSPGKEENENRDLTAESKKIYMGKQESKDSFKQLAKLVTSGAESGNLNTSPSSNQTRNSEKFEKPENEIEAQLICEPPINGSSTPNPKIASSVTAGVASSLSEKIADSIGNNRQNAPLTSIQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF

Nedd1

Protein NEDD1

660 amino acids

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (By similarity). May play an important role during the embryonic development and differentiation of the central nervous system (PubMed:1378265).

71.292 kDa

MQENLRFASSGDDVKIWDASFLTLVDKFNPHTSPHGISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKASLSKGSSNKATAVNKRSVPVSSSSGAAQNSGIVREAPSPSIATVLPQPVTTALGKGSGAAQDEAGLARSKSTDIFSKETDAGKSQDFSSFDDTGKNSLGDMFSPIRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPLRKNAGASSSLVLHSSPLNVLMGSSGKEENESHEPSAESKRAYLGKQEPKDAMKQFTKLISSGAEPGILNTCPSSNQARNLEKFEKPEKDIEAQLIHEPSVNGSSTTVPKAASSVTAGVASSLSEKIVDTLGNSRPGAPLTSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHIQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF

NEDD1

Protein NEDD1

659 amino acids

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

71.204 kDa

MQENLRFASSGDDVKIWDASSMTLVDKFNPHTAPHAISSVCWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELGEGQKQTCVSLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDEVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSIRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSTHKAPASGICFSPVNELLFVTVGLDKRIILYDTSSKKLVKTLVADAPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPIKTISAHKTSVQCIAFQYSTVLSKSGLNKGCSNKPTAVNKRTANVSAGGGGAQNPGVVREAATTSIATVPPQPTAAAVGKGAVAPQDKAGLPRSINTDTLSKEAESGKNQDFSNFDDSGKSSLGDMFSPVRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPPRKNPVVSSTSVLHSSPLNVFMGSPGKEENENHDLTAESKKMYLGKQESKDSFKQFAKLISGAETGNLNASPSSNQTRSPEKFEKPEKEIEAQLINEPPGNGSSTPNPKIASSVTAGVAGSLSEKIVDTIGNSRPNAPLSSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF