Protein
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI)
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Similarity
Belongs to the NnrD/CARKD family.
Sequence
MSTEDLNMSAATKNVLAKVRRIIPPMLESFHKGQLGRVAVIGGSENYTGAPYFSAMASARLGCDMSHVICTPAAATVIKSYSPNLMVHPLMRQSPAPNPNQDPATRDTSKDPDSDPEHISAQIIDLLPRLHVLVVGPGLGRDPLMHATVARVIRAARNRGTPVVLDADALILVQKDPGLVRGYDGAVLTPNVVEFAKLCEALKVDVSEGASETARVEALAKTLEGVTVIQKGAKDYISNGETTLTVDLQGGRKRSGGQGDTLTGSIATFLGWRKAYLDRLWDVGQNALGEHELVGLAAFGGAAITRECSRLAFAKKGRSLQASDLTEEVHVAFLNIFGEEDEETDSSRL