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NCU11297

Gene
NCU11297
Protein
Very-long-chain 3-oxoacyl-CoA reductase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
332 amino acids
Function
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
36.784 kDa
Sequence
MDKVAEIWGTVPQYGQWALAGIGALYVATRVGAFLQLLLNAFILSGTNLRKYGKKGTWAVITGASDGLGKEFAQQLASKGFNLVLVSRTQSKLDVLARELELRWDGFKAKTFAMDFSKDDDSDYERLAELIKGLDIGILINNVGQSHSIPVPFLQTDRDELQNIVTINCLGTLKTTKVVAPILAQRKKGLILTMGSFAGVMPTPYLATYSGSKAFLQHWSSALSAELKDQGVDVHLVVSYLVTTAMSKIRRTSLLIPNPKQFVRAALGKVGLNSSEPFPNTYTPWWSHAVFKWVVENTVGAYSYFTLRLNKNMHIDIRNRALRKAAREAKKQ