Protein
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Similarity
Belongs to the NnrD/CARKD family.
Sequence
MSSESSTGPEMSATTKQMLARVRQMVPPMLEKFHKGQLGRVAVIGGSEDYTGAPYFSAMASARLGADLSHVICTPNAAQVIKTYSPNLMVHPLMRSSPPALSSSDSGSSPSRTKSAPDTDPSQIAAQIIPMLDRLHVLVIGPGLGRDPLMQETCAKVITAAREKGIPMVLDADALLLVTKDPSLIKGYDNAVLTPNVVEFGRLTKALGVDEEVEKAEETAGETAKVEALAKALGGVMVVQKGAKDYLSDGKVTLTVDLKGGLKRSGGQGDTLTGSIATFLGWRRAYLEDLWDHGHKLNKEELIGLAVFGGSAITRECSRLAFAKKGRSLQASDLTDEVHTAFLNLFGEVDAKL