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NCU01341

Gene
NCU01341
Protein
U1 small nuclear ribonucleoprotein C
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
216 amino acids
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Similarity
Belongs to the U1 small nuclear ribonucleoprotein C family.
Mass
21.527 kDa
Sequence
MPKFFCDYCDVYLTHDSMSVRKAHNSGRNHLRNVVDYYQQIGHEKAQSVIDSITSSYAAEGQAHANPMLPQNQPGGVPPGLGFPPPGAGVPPFPPFPGGMPPPFPGMPGGAPVPPPGAFGAPGVPGGIPPPGAPGARGMPPMPPFPGMPGAPAGIPGVPPPMPGPGGLPFPPPGGLPFPPPGAGNFPFPPPGAPGAFPGMPPFGAPGQGPPGADKR