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NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
469 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
54.275 kDa
Sequence
MTAEQCQRCNKNAVEVISRKELFCAECFRVFVMQKQRKQMMSDDYYRDIFKVMYKDKIRSAEEAEQQNKNSTILIPLSFGSSSLMMLDIVHLTLLEQKMQHQKTGFNVDVLICYRESNDELLTNIQSNIKELSTVRYSENKDNIRFHTLCLDSMFEIDKELIDQVVLHNVEFTGRQVSINESEHANLSLQTVLTSCPNRSTKEDIIDFVTKHLVKKYAYQNGQKAILWGHSMTRLADEIISCVVKGRGAQISSKLNTTNLDVNYGSRFKNLYPLKDILLTEVDAYCALFDLSKYLIKYELQDSLLVNKLKKEKHIGNQRLAKNMTINELARKYFNDIEGEYSNVIATVLRTGDKLDEPLATLGEKHCRICKSTVHDDVSKWLRDITVNVGQPLESQLERDLHEKWATSHIGLETTAYYQLRDRVWEQGDDVDLCYGCIVTMQGVKNLNVPWPKNNEQELNEVLAEYSLE
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
469 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
54.275 kDa
Sequence
MTAEQCQRCNKNAVEVISRKELFCAECFRVFVMQKQRKQMMSDDYYRDIFKVMYKDKIRSAEEAEQQNKNSTILIPLSFGSSSLMMLDIVHLTLLEQKMQHQKTGFNVDVLICYRESNDELLTNIQSNIKELSTVRYSENKDNIRFHTLCLDSMFEIDKELIDQVVLHNVEFTGRQVSINESEHANLSLQTVLTSCPNRSTKEDIIDFVTKHLVKKYAYQNGQKAILWGHSMTRLADEIISCVVKGRGAQISSKLNTTNLDVNYGSRFKNLYPLKDILLTEVDAYCALFDLSKYLIKYELQDSLLVNKLKKEKHIGNQRLAKNMTINELARKYFNDIEGEYSNVIATVLRTGDKLDEPLATLGEKHCRICKSTVHDDVSKWLRDITVNVGQPLESQLERDLHEKWATSHIGLETTAYYQLRDRVWEQGDDVDLCYGCIVTMQGVKNLNVPWPKNNEQELNEVLAEYSLE
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
463 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
52.84 kDa
Sequence
MVICKRCKLLDATLVSRKEPFCDECFVKFISLKQRKQMMSDDYFQDIFKISYPDKKRGQAEADKQNQDSNVLVPLSLGSSSLAVLDILNDTLLEQKQTHRGKTGFHVEVITICGQAEFEEVRGKIELLKSKYKENSDKILFHIVDRNQFFAVPFDLQEITLYIDNFNTLVRSSNNPSTTVEKVLASAPNKTAKEDLLNIIYTHLIKKFALQRNFKAILWGHSMTKLADEVISLTVKGRGAEIAGYLDDSSLDSKYNTAFRNFHPGRDVLLSEIDAYCHIKGLSQFSHNYVVQDTLFYDKFVDKPTKNVKLIKNMTMNELARQYFDNIEGDYSNVISTVVRTGAKLSNPDNELNQIMHCSICNAIIYKNPVNWLDGITVSKPFVIHNEEELTNYNAWEAANPDKAEKLNKMSDTPAKNVGVCYGCITTLTGMKDRKLEWIRRDDKAELTAVLQEYEIPSDDSEQ
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
461 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
52.405 kDa
Sequence
MKCKRCTTSEGCLVSRNETFCGECFSRFVLLKFRKQMMMDEYCQQVFKVLYADKHRTAVEADEQNKRSVVLVPLSLGSSSLAMLDLLNQTLSEQRAAHNRTGFQVKVVLCGFSADMDELKRLAESLQTERLAMNSDCIKLYLLDLDRSFSTCEIHKLLLANDNHGSRKIATRENATLSSILDQFSRRSSRDDMLWFARQHLIKKFASQHQVKVIMWGHSVTRLADEVMSLVIKGRGAQIAATLDSTGMDVEYGALFKNLYPLRDVLLSEIDAYCSLSKLQRYIYNYSLQGSLFIKSQDEAAQANRAVPMAKNMTINELTRQYFDAVEKDYSNVISTIVRTASKLDYPISNGTEVIYCSICNNRVYVDPSKWLKSITVNNCHPPASDEDMSMLQMWESSSKGKETLARNQARSNIWSTAAEAPLCYGCVVTLNETKDRELNWPSREHDVSQVLAEFTLTDEE
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
461 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
52.405 kDa
Sequence
MKCKRCTTSEGCLVSRNETFCGECFSRFVLLKFRKQMMMDEYCQQVFKVLYADKHRTAVEADEQNKRSVVLVPLSLGSSSLAMLDLLNQTLSEQRAAHNRTGFQVKVVLCGFSADMDELKRLAESLQTERLAMNSDCIKLYLLDLDRSFSTCEIHKLLLANDNHGSRKIATRENATLSSILDQFSRRSSRDDMLWFARQHLIKKFASQHQVKVIMWGHSVTRLADEVMSLVIKGRGAQIAATLDSTGMDVEYGALFKNLYPLRDVLLSEIDAYCSLSKLQRYIYNYSLQGSLFIKSQDEAAQANRAVPMAKNMTINELTRQYFDAVEKDYSNVISTIVRTASKLDYPISNGTEVIYCSICNNRVYVDPSKWLKSITVNNCHPPASDEDMSMLQMWESSSKGKETLARNQARSNIWSTAAEAPLCYGCVVTLNETKDRELNWPSREHDVSQVLAEFTLTDEE
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
452 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
51.001 kDa
Sequence
MPEAIVYLTETEICQKCKTENAVVHARVEKLCSNCYIRFIRGKLRKQMHDERYKVKFGRAVEQYGTQRILLALSGGESSLVLLDIFGSLLQEQNELHKGKQGFELVVVNLDEYELDSLNNRIQKVFPELLAKYQPVKISLNVLSLDSYVDEESLHRILLTPDFRAMSKSIDPTRVTLTEILRLCPNKSSAEDLLTIVYNDLILRVAAKEDCQTVVYGHCMTRLANEIIALTVKGRGSIIHKSIADHTETIDDKEIKVMFPLREILQAEISAYVKLAELNKYVISSTVQKSKINKNLTIRDLTTNYFKQLDATGYASTASTVAKTGEKLGSPSNVLCQCQICGADIHQNPSNWLKRITVTDPAAITTDEEKEYYEMFRASLSPDNEDKNNSDSPIDICFGCTVTLGGVKGDTGFIWPLQGSSELKYEYRNDNQEKQKVLDEFVLTDDEGDIEV
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
452 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
51.001 kDa
Sequence
MPEAIVYLTETEICQKCKTENAVVHARVEKLCSNCYIRFIRGKLRKQMHDERYKVKFGRAVEQYGTQRILLALSGGESSLVLLDIFGSLLQEQNELHKGKQGFELVVVNLDEYELDSLNNRIQKVFPELLAKYQPVKISLNVLSLDSYVDEESLHRILLTPDFRAMSKSIDPTRVTLTEILRLCPNKSSAEDLLTIVYNDLILRVAAKEDCQTVVYGHCMTRLANEIIALTVKGRGSIIHKSIADHTETIDDKEIKVMFPLREILQAEISAYVKLAELNKYVISSTVQKSKINKNLTIRDLTTNYFKQLDATGYASTASTVAKTGEKLGSPSNVLCQCQICGADIHQNPSNWLKRITVTDPAAITTDEEKEYYEMFRASLSPDNEDKNNSDSPIDICFGCTVTLGGVKGDTGFIWPLQGSSELKYEYRNDNQEKQKVLDEFVLTDDEGDIEV
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
448 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
51.115 kDa
Sequence
MSQPIQYLDVSENIPCSRCKTETAILISRKEKFCKDCFVRFIRGKQRKQMQDEKYKVKYGKNEENSPVQKVLLTLSCGVSSLVLVDVMTSLLKEQFDMHKGKQGFELVLLNINEYELKALDRSVKDVLEQLVQRFKPINITYKILSLESYVLDQSLLEKIVLNGDFTAYSQSIHHDRDYTLSEVLDLCPNKSSLEDLLTIIYDELILRTACLESCETILYGHSMTRIANEIIALTVKGRGSSIYQTVSDHSVNFRNKDYKIIFPLRDVLFAEILAYSKLSELDTFAVESTKPVSKITKNMTIRDLTTNYFNQLDATGYASTASTVVKTGDKLGAPKFEEDSSICQVCGTEIHQDPKEWLRRITVNKAAPLETEEEKEYAEQYKKASSLIEEPSSTQSKTPINICYGCTVTISGIKNESGFIWPIKYPANDEEREILNEYILTDDEDDQ
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
448 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
51.115 kDa
Sequence
MSQPIQYLDVSENIPCSRCKTETAILISRKEKFCKDCFVRFIRGKQRKQMQDEKYKVKYGKNEENSPVQKVLLTLSCGVSSLVLVDVMTSLLKEQFDMHKGKQGFELVLLNINEYELKALDRSVKDVLEQLVQRFKPINITYKILSLESYVLDQSLLEKIVLNGDFTAYSQSIHHDRDYTLSEVLDLCPNKSSLEDLLTIIYDELILRTACLESCETILYGHSMTRIANEIIALTVKGRGSSIYQTVSDHSVNFRNKDYKIIFPLRDVLFAEILAYSKLSELDTFAVESTKPVSKITKNMTIRDLTTNYFNQLDATGYASTASTVVKTGDKLGAPKFEEDSSICQVCGTEIHQDPKEWLRRITVNKAAPLETEEEKEYAEQYKKASSLIEEPSSTQSKTPINICYGCTVTISGIKNESGFIWPIKYPANDEEREILNEYILTDDEDDQ
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
448 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
50.422 kDa
Sequence
MKSLEYLTETGIKCLKCDEGAIIKVRSDVYCKQCYLRFIRGKQRKQMSSDKYKVKYLRDGASHSTEKVLLAFSGGVSSLVLLDVLARLLEEQKNTHRDLQGFELVVANISESDGTNLESLLSSSSIMQTLLELVGNYEVSIKVKVVTPNIDPVFLRRIGVDYEFNTFANNLSIEEQSVSSLAEILRASPNRSSSEDLRDVIFHQELLRLAQSEGCGTIVYGHSMSRLAIEVLALTVKGRGSNVHSTILDRVEDYCGDQISIIYPFRDLFEYELREYAVLSDLMQYESAFAKYAVPKSKVSKNMTVREILSMYLDRWDESGYLSTASTVVKIGEKLTVPTSQNNSSTYCCDICAKKIYQDPKDWLQMITVNEPAPLVSDEERDYLHQYLTSHTDTISKSGEHVNLCYGCITAINGAGGDSGVIWPLQKDVKFDHGEKEKAKVLKEYSLE
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
420 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
46.516 kDa
Sequence
MSLAVEYISDKTPCQRCSTKDAVLLARRENYCGDCFIRFIRGKQRRSMQDEAYKVKYKTVENPHRVLLALSGGSSSLVLLDAVASLLQEQAGQHGGRQGFALTVVNVDERERLKLDKSFQDIISELKSRYLPVDIDFVSLDYDMYVDGRLLHHIKVASDFSSYSIPLNKGTNINDILKGCNSKSSEEDLLSIILNELLLKTAITHQCGTLLYGHSMTRLADEVLALTIKGRGSTIHSSVLDHTEEISGQTINVKYPLRDVLMGEIEAYCKLAKLDSVVMSSTIPDPVINKNKTVRGLTAQYFRQLDATGYSSTASTVVRTAAKLAAPTVGTKSGTCKVCGVEIRQDPHQWLRRITVAENEKVENNSEESGEIGADKKEDVGEQIDLCYGCTVTIGDAPSFRWPLSDKDIIAEYTLDSDED
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
382 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
41.72 kDa
Sequence
MPGKHSDSATSELCEKCKENISILVVRAKPICHDCFARYVHTKAIKRLESFRVNFAASPDQQRKILLPLSHGVSSTTLLHILDLHLNTQRSKTNRTGFAISVLVVDEGSLDPARLDKVRERYANHDYASLPLHDVFRLLPDDASLRAFLPESQVQEVCSTQEQLTSLIASLTSATARADVLTTLRTRLIVEHAKQTGCESILWGDSTTRLAEKTLAETAKGRGFSLPWQISDGKSPFDINFHYPLRDVLKKELFSYVDLAEPALSALVYEPQSGATQASMSSKNTTIDDLMKQYFESVEENFPSIVSNVVRTTGKLEVPTGATSNPRCSLCGMPVPDGRFGIHGWGGDQHGGADDAAAVSGGSLCYGCTRSIPQRGTAVASK
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Coccidioides immitis (strain RS)
Length
376 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
41.823 kDa
Sequence
MSCVDCRFAPACVTVRTRNLCENCFIRFLQTKVLRRMERYRLRNAPKDRQRKLILPLSYGVSSLALLHIVSSLLLKQRTTGQKRTAFDLHVLIVDPVSLHPSKGAAASGRLAKIKEAYPDNTYSEVPLRSIFDYDPDIRGDISQHTGIPLGSNPSRSDEEILNLFRASFSTATARADIDGILLRRLIVAFAKSHKCDGILWGDSDSRLAAKTLANVAKGRGSSLVWNVCEGMSPWDIYFNFPLRDLYKSELEVYASYALRDLQQIIDQDPRNFEDLSNRHMSIEDLMSQYVLTQGAKYPGVMANIVRTVDKLTTPGVENAKMCILCRVPAGENLNAASGSQMDIGSNGETTTVPRSTCYGCMRTLLDMKAPTSNSG
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Coccidioides immitis (strain RS)
Length
376 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
41.823 kDa
Sequence
MSCVDCRFAPACVTVRTRNLCENCFIRFLQTKVLRRMERYRLRNAPKDRQRKLILPLSYGVSSLALLHIVSSLLLKQRTTGQKRTAFDLHVLIVDPVSLHPSKGAAASGRLAKIKEAYPDNTYSEVPLRSIFDYDPDIRGDISQHTGIPLGSNPSRSDEEILNLFRASFSTATARADIDGILLRRLIVAFAKSHKCDGILWGDSDSRLAAKTLANVAKGRGSSLVWNVCEGMSPWDIYFNFPLRDLYKSELEVYASYALRDLQQIIDQDPRNFEDLSNRHMSIEDLMSQYVLTQGAKYPGVMANIVRTVDKLTTPGVENAKMCILCRVPAGENLNAASGSQMDIGSNGETTTVPRSTCYGCMRTLLDMKAPTSNSG
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
374 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
41.489 kDa
Sequence
MPGKELTDPCVDCADAEAILTVRCRRLCQDCYARFVNFKVFKRMENYRLRRNMSRTGPCKLLLPLSYGTSSSVLLHILNAQIQHERAKSHPSPGFELHVLVIEPSTVSTSSPPHDEGFDLLQQTFPSHSFTRVSLHNVFELDPSIQDVLSQFSSEGFTDDATMSDKDRLDAFRASITTATSRVDVDYILITRLVVAFAKKIECRGVVWGDSDTRLAAKTLANVAKGRGSAITWQVCDGMSPFGLEFSFPLRDLYKAEVQNYASFFPELAKIIIPDEPPSENILTKNLSIDELMMRYVQTQGEKYPGIMANVTRTASKLQASLVPANVPRCSFCGGSMLNQDGQIIMGGAAGNSEVRQGAELCYACTRSRPEVSY
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
374 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
41.489 kDa
Sequence
MPGKELTDPCVDCADAEAILTVRCRRLCQDCYARFVNFKVFKRMENYRLRRNMSRTGPCKLLLPLSYGTSSSVLLHILNAQIQHERAKSHPSPGFELHVLVIEPSTVSTSSPPHDEGFDLLQQTFPSHSFTRVSLHNVFELDPSIQDVLSQFSSEGFTDDATMSDKDRLDAFRASITTATSRVDVDYILITRLVVAFAKKIECRGVVWGDSDTRLAAKTLANVAKGRGSAITWQVCDGMSPFGLEFSFPLRDLYKAEVQNYASFFPELAKIIIPDEPPSENILTKNLSIDELMMRYVQTQGEKYPGIMANVTRTASKLQASLVPANVPRCSFCGGSMLNQDGQIIMGGAAGNSEVRQGAELCYACTRSRPEVSY
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
370 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
40.809 kDa
Sequence
MPGKQLSDPCVDCSDAEAILTLRTRRLCQTCYARFVNFKVFKRMENYRLRRNMPKTGPCKLLLPLSCGISSSVLLHILNAQIQLELAKSHPSPGFDLHVLVIEPSSISHSSPSYDEGFGLLQQTFPLHSFTRIPLHSIFELDPELQEVISQFSKDGFVDDAGLSAKERLDAFRASIPTSTSKVDVDYVLITRLVVAFAKKIACRGVLWGDSDTRLAAKTLANVAKGRGSSLTWQVCDGMSPFGVEFNFPLRDLFKAEVDNYASFFPELTRIIIPDEPPSENVLTKNLSIDELMMRYVQTQGEKYPGVMANVTRTASKLQASLTPANVPQCSFCGAFMLNSGNNGGGDTTGASRALELCYACTRSRPELTC
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
366 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
41.184 kDa
Sequence
MPGKELPDRCMNCHEAEPAFLLRERHVCQECYIRFLNFKPFRRMERYRLRRNMPQTGPCKLLLPLSYGVSSTVLLHMLHRQLEALRSKKHGPAGFEILVLVVEPSTISPVPPHEEGFALAQQTFPLCSFTRLPFHSIFELDPDVHQIMSQYAGEHFTDDTSLSDEERLNRFRRSITTATSKSDVDQILLNKLVVAFAKKMECRGIVWGDSDSKLAAKTLANVAKGRGSAVTWQVCDGMSPFGLEFNFPLRDVFTAEIRTYATLFPELAGIIVHDEPPSENTLTKNLSIDELMIRYVSTQGEKYPGVMLNVTRTASKLQSSGTSIGGLQCNFCGAFMTTNENITGEQGNEQLQFCYACARSQPELSC
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
366 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
41.184 kDa
Sequence
MPGKELPDRCMNCHEAEPAFLLRERHVCQECYIRFLNFKPFRRMERYRLRRNMPQTGPCKLLLPLSYGVSSTVLLHMLHRQLEALRSKKHGPAGFEILVLVVEPSTISPVPPHEEGFALAQQTFPLCSFTRLPFHSIFELDPDVHQIMSQYAGEHFTDDTSLSDEERLNRFRRSITTATSKSDVDQILLNKLVVAFAKKMECRGIVWGDSDSKLAAKTLANVAKGRGSAVTWQVCDGMSPFGLEFNFPLRDVFTAEIRTYATLFPELAGIIVHDEPPSENTLTKNLSIDELMIRYVSTQGEKYPGVMLNVTRTASKLQSSGTSIGGLQCNFCGAFMTTNENITGEQGNEQLQFCYACARSQPELSC
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
Length
364 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
40.517 kDa
Sequence
MQVCWFERFGGGNQLLTVLSSSRTCYARFVNFKVFKRMENYRLRRNMPRTGPCKLLLPLSCGISSSVLLHILNAQIQHELAKSHPSPGFDLHLLVIEPSSISHSSLSYDEGFELLQQTFPLHSFTRIPLHSIFELDPELQEVISQFSKDGFVDDTGLSAKERLDAFRASIPTSTSKVDVDYILITRLVVAFAKKIACRGVLWGDTDTRLAAKTLANVAKGRGSSLTWQVCDGMSPFGVEFNFPLRDLFKAEVDNYASFFPELTRIIIPDEPPSENVLTKNLSIDELMMRYVQTQGEKYPGVMANVTRTASKLQASLMPANVPQCSFCGAFMLNSGNNDGGDTTGASRALELCYACIRSRPELTC
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
364 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
40.517 kDa
Sequence
MQVCWFERFGGGNQLLTVLSSSRTCYARFVNFKVFKRMENYRLRRNMPRTGPCKLLLPLSCGISSSVLLHILNAQIQHELAKSHPSPGFDLHLLVIEPSSISHSSLSYDEGFELLQQTFPLHSFTRIPLHSIFELDPELQEVISQFSKDGFVDDTGLSAKERLDAFRASIPTSTSKVDVDYILITRLVVAFAKKIACRGVLWGDTDTRLAAKTLANVAKGRGSSLTWQVCDGMSPFGVEFNFPLRDLFKAEVDNYASFFPELTRIIIPDEPPSENVLTKNLSIDELMMRYVQTQGEKYPGVMANVTRTASKLQASLMPANVPQCSFCGAFMLNSGNNDGGDTTGASRALELCYACIRSRPELTC
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
Length
364 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
40.517 kDa
Sequence
MQVCWFERFGGGNQLLTVLSSSRTCYARFVNFKVFKRMENYRLRRNMPRTGPCKLLLPLSCGISSSVLLHILNAQIQHELAKSHPSPGFDLHLLVIEPSSISHSSLSYDEGFELLQQTFPLHSFTRIPLHSIFELDPELQEVISQFSKDGFVDDTGLSAKERLDAFRASIPTSTSKVDVDYILITRLVVAFAKKIACRGVLWGDTDTRLAAKTLANVAKGRGSSLTWQVCDGMSPFGVEFNFPLRDLFKAEVDNYASFFPELTRIIIPDEPPSENVLTKNLSIDELMMRYVQTQGEKYPGVMANVTRTASKLQASLMPANVPQCSFCGAFMLNSGNNDGGDTTGASRALELCYACIRSRPELTC
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
364 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
40.517 kDa
Sequence
MQVCWFERFGGGNQLLTVLSSSRTCYARFVNFKVFKRMENYRLRRNMPRTGPCKLLLPLSCGISSSVLLHILNAQIQHELAKSHPSPGFDLHLLVIEPSSISHSSLSYDEGFELLQQTFPLHSFTRIPLHSIFELDPELQEVISQFSKDGFVDDTGLSAKERLDAFRASIPTSTSKVDVDYILITRLVVAFAKKIACRGVLWGDTDTRLAAKTLANVAKGRGSSLTWQVCDGMSPFGVEFNFPLRDLFKAEVDNYASFFPELTRIIIPDEPPSENVLTKNLSIDELMMRYVQTQGEKYPGVMANVTRTASKLQASLMPANVPQCSFCGAFMLNSGNNDGGDTTGASRALELCYACIRSRPELTC
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
361 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
40.273 kDa
Sequence
MPGKELSDPCVDCRDAEAILTLRRRRLCKDCYIKFVSYKVFKRMENYRLNRGFAKDKPCKLLFPLSYGLSSSVLLHMLHDQLEVQRSKVHGSPGFDLHVLIIEPSTISPSNPAHDEGFELAQKCFPLCSFTKVPFHSIFALVPDIKETMSQFAGKGFEDDPSLSDAERLNAFRSCIATSTSKADVDHILMNRLIVAFAKQMDCQAIIWGDSDSRLAAKTLANVAKGRGSSVIWQVSDGMSPFGLEFNFPLRDLFTAELRDYASFFPELTKLIVPDEPLPANTLTKNLSIDELMMRYVLTQGEKYPGVMLNVTRTANKLDVSQMPANLSHCTFCAAPLMNEVGGGHTQFCYACARSRPSTSS
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
361 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
40.273 kDa
Sequence
MPGKELSDPCVDCRDAEAILTLRRRRLCKDCYIKFVSYKVFKRMENYRLNRGFAKDKPCKLLFPLSYGLSSSVLLHMLHDQLEVQRSKVHGSPGFDLHVLIIEPSTISPSNPAHDEGFELAQKCFPLCSFTKVPFHSIFALVPDIKETMSQFAGKGFEDDPSLSDAERLNAFRSCIATSTSKADVDHILMNRLIVAFAKQMDCQAIIWGDSDSRLAAKTLANVAKGRGSSVIWQVSDGMSPFGLEFNFPLRDLFTAELRDYASFFPELTKLIVPDEPLPANTLTKNLSIDELMMRYVLTQGEKYPGVMLNVTRTANKLDVSQMPANLSHCTFCAAPLMNEVGGGHTQFCYACARSRPSTSS
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
NCS2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Ajellomyces capsulatus (strain NAm1 / WU24)
Length
359 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
39.965 kDa
Sequence
MTLDSRYGGEVYGGSKVVKRMEKYRPQNAPKNRQRKLLLPLSYGISSSTLLHILNLQLERQISSGLGRRAYDIHVLNIGTCEQSDSHRLGLFREAYPLHTYTQVPLHSIFKHDTTIKDVISEYGGPEFADDPSKTDQERLDIFRLSLSTATARADIDGILLTRLVVAIAKEQDCDGILWGDSDTRLASKALSNVAKGRGFSVPWDVCDGMSPWGIQFNFPMRDLFKFELSTYASLALPKSLNVVDSERPSVDNLSNKNMSIEDLLAHYVETQGQKYPGVMANIVRTINKLQPQSADTDHKCMLCGMPVDYSGEDPAIIGGQGSSQYTLQDWRERPVAGTLCYGCARTRLDLVPPRSVSS
Protein
Cytoplasmic tRNA 2-thiolation protein 2: NCS2

Gene
ncs2
Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
325 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ncs6 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
Similarity
Belongs to the CTU2/NCS2 family.
Mass
35.876 kDa
Sequence
MEKYRLRRDLPRSGPCPVLLPLSYGLSSSVLLHMVHGQVERLLTKPHPPPGFELHVLIVEPSSISPSNPSHRGAFQLLQQQFPHASFTQLPLHSVFDYVSGLNDILAEYVGPAFVDDTSLPSKERLDAFRASITSATSAADVDSVLLNRLIIAFARSLGCLGIIWGDSDDRLAAKTLANVSKGRGSSLTWQVSDGTSPFGLEFSFPLRDLFTAELQSYANFFPELLNIIIPDGPLSDNILTKNLSIDQLMMRYVSSQGAKYPGVMSNVTRTVNKLESSRMITDGLRCALCDTFICNPEGRQTMDLEERPTNHFCYACERSRPGLS
Protein
Cytoplasmic tRNA 2-thiolation protein 2: ncs2

Gene
NCS2
Protein
S-norcoclaurine synthase 2
Organism
Papaver somniferum
Length
231 amino acids
Function
Involved in the biosynthesis of (S)-coclaurine, the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or papaverine. Condenses dopamine and 4-hydroxyphenylacetaldehyde.
Similarity
Belongs to the BetVI family.
Mass
26.001 kDa
Sequence
MSKLITTEPLKSMAEVISNYVIQRESFSARNILNKNSLVKKEIRYDLEVPTSADSIWSVYSCPDIPRLLRDVLLPGVFQKLDVIEGNGGVGTVLDIVFPPGAVPRSYKEKFVNINHEKRLKEVIMIEGGYLDMGCTFYMDRIHIFEKTPNSCVIESSIIYEVKEEYAGKMAKLITTEPLESMAEVISGYVLKKRLQVFGFEIKPKLRFNLLLCLIICLVIAGGMFVAGVPL
Protein
S-norcoclaurine synthase 2: NCS2